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Conference Paper: Impaired chronotropic response limits exercise tolerance in peritoneal dialysis and renal transplant patients

TitleImpaired chronotropic response limits exercise tolerance in peritoneal dialysis and renal transplant patients
Authors
KeywordsMedical sciences
Urology and nephrology
Issue Date2012
PublisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org
Citation
The 45th Annual Meeting of the American Society of Nephrology (Kidney Week 2012), San Diego, CA., 30 October-4 November 4 2012. In Journal of the American Society of Nephrology, 2012, v. 23 abstract suppl., p. 790A, abstract SA-PO654 How to Cite?
AbstractBACKGROUND: Chronotropic incompetence (CI), defined as blunted increase in heart rate (HR) during exercise, has been accepted as an independent predictor of cardiovascular mortality. Little is known about its prevalence in peritoneal dialysis (PD) and renal transplant (RT) patients. This study aimed to investigate the prevalence of CI and its relationships with exercise intolerance in these patients. METHODS: Ambulatory PD and RT patients were recruited for treadmill stress test using modified Bruce protocol. Exercise duration and HR response was recorded. Maximum age-predicted HR was defined as (220-age). Heart rate reserve was defined as difference between peak heart rate achieved during exercise and resting heart rate. Chronotropic response (CR) to exercise was evaluated by the percentage of heart rate reserve ([peak HR-resting HR/maximal age predicted HR-resting HR]x100%). RESULTS: 86 patients (mean age 51.72±8.78 years, male 53.5%) were included in this study. RT patients had significantly longer exercise duration than PD patients (10.01±3.59 min Vs 6.26±3.16 min, P=0.000). Both PD and RT patients demonstrated blunted HR response to exercise. PD patients had significantly lower maximum heart rate than RT patients (75.34±13.67% Vs 86.57±23.56% of age-predicted HR respectively, p=0.009). CR was also significantly lower in PD than RT patients (58.64±24.11% Vs 79.73±43.54%, p=0.008). CI (i.e. CR<80%) was noted in 28 (64%) PD and 15 (36%) RT patients respectively. CONCLUSIONS: Chronotropic incompetence was more prevalent in PD than RT patients and such difference might account for the discrepancy in their exercise tolerance.
DescriptionSaturday Poster - Mineral Disease: Ca/Mg/PO4 - abstract SA-PO654
Persistent Identifierhttp://hdl.handle.net/10722/185010
ISSN
2015 Impact Factor: 8.491
2015 SCImago Journal Rankings: 4.699

 

DC FieldValueLanguage
dc.contributor.authorMa, MKMen_US
dc.contributor.authorSiu, DCWen_US
dc.contributor.authorLo, WKen_US
dc.contributor.authorYap, DYHen_US
dc.contributor.authorChan, DTM-
dc.date.accessioned2013-07-15T10:23:49Z-
dc.date.available2013-07-15T10:23:49Z-
dc.date.issued2012en_US
dc.identifier.citationThe 45th Annual Meeting of the American Society of Nephrology (Kidney Week 2012), San Diego, CA., 30 October-4 November 4 2012. In Journal of the American Society of Nephrology, 2012, v. 23 abstract suppl., p. 790A, abstract SA-PO654en_US
dc.identifier.issn1046-6673-
dc.identifier.urihttp://hdl.handle.net/10722/185010-
dc.descriptionSaturday Poster - Mineral Disease: Ca/Mg/PO4 - abstract SA-PO654-
dc.description.abstractBACKGROUND: Chronotropic incompetence (CI), defined as blunted increase in heart rate (HR) during exercise, has been accepted as an independent predictor of cardiovascular mortality. Little is known about its prevalence in peritoneal dialysis (PD) and renal transplant (RT) patients. This study aimed to investigate the prevalence of CI and its relationships with exercise intolerance in these patients. METHODS: Ambulatory PD and RT patients were recruited for treadmill stress test using modified Bruce protocol. Exercise duration and HR response was recorded. Maximum age-predicted HR was defined as (220-age). Heart rate reserve was defined as difference between peak heart rate achieved during exercise and resting heart rate. Chronotropic response (CR) to exercise was evaluated by the percentage of heart rate reserve ([peak HR-resting HR/maximal age predicted HR-resting HR]x100%). RESULTS: 86 patients (mean age 51.72±8.78 years, male 53.5%) were included in this study. RT patients had significantly longer exercise duration than PD patients (10.01±3.59 min Vs 6.26±3.16 min, P=0.000). Both PD and RT patients demonstrated blunted HR response to exercise. PD patients had significantly lower maximum heart rate than RT patients (75.34±13.67% Vs 86.57±23.56% of age-predicted HR respectively, p=0.009). CR was also significantly lower in PD than RT patients (58.64±24.11% Vs 79.73±43.54%, p=0.008). CI (i.e. CR<80%) was noted in 28 (64%) PD and 15 (36%) RT patients respectively. CONCLUSIONS: Chronotropic incompetence was more prevalent in PD than RT patients and such difference might account for the discrepancy in their exercise tolerance.-
dc.languageengen_US
dc.publisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org-
dc.relation.ispartofJournal of the American Society of Nephrologyen_US
dc.relation.ispartofKidney Week 2012-
dc.subjectMedical sciences-
dc.subjectUrology and nephrology-
dc.titleImpaired chronotropic response limits exercise tolerance in peritoneal dialysis and renal transplant patientsen_US
dc.typeConference_Paperen_US
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hken_US
dc.identifier.emailYap, DYH: desmondy@hku.hk-
dc.identifier.emailChan, DTM: dtmchan@hku.hk-
dc.identifier.authoritySiu, DCW=rp00534en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros215597en_US
dc.identifier.volume23-
dc.identifier.issueabstract suppl.-
dc.identifier.spage790A, abstract SA-PO654-
dc.identifier.epage790A, abstract SA-PO654-
dc.publisher.placeUnited States-

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