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  Patent History
  • Application
    PC T/CN2004000209 2004-03-17
  • Publication
    WO 2004083434 2004-09-30

published patent: A COMBINED ADENO-ASSOCIATED VIRUS AND ADENOVIRUS COCKTAIL GENE DELIVERY SYSTEM FOR HIGH EFFIENCY GENE EXPRESSION WITHOUT ELICITING IMMUNE RESPONSE IN IMMUNO-COMPETENT SUBJECTS

TitleA COMBINED ADENO-ASSOCIATED VIRUS AND ADENOVIRUS COCKTAIL GENE DELIVERY SYSTEM FOR HIGH EFFIENCY GENE EXPRESSION WITHOUT ELICITING IMMUNE RESPONSE IN IMMUNO-COMPETENT SUBJECTS
Priority Date2003-03-17 US 10/455188P
Inventors
Issue Date2004
Citation
WO Published patent application WO 2004083434. World Intellectual Property Organization (WIPO), PatentScope, 2004 How to Cite?
AbstractThe present invention provides an efficient gene delivery system using Adeno-Associated Viral (AAV) vector in gene therapy. Furthermore, the invention provides a combined AAV and Adenovirus (Adv) cocktail gene delivery system which is even more efficient in in vivo gene delivery and expression without eliciting any significant immune responses in an immunocompetent subject. In particular, the invention provides a therapeutic agent and methods for preventing, treating, managing, or ameliorating various diseases and disorders including, but not limited to, bone diseases, by delivering Bone Morphogenetic Protein 2 (BMP-2) for new bone formation via gene therapy using said system. The invention provides a nucleic acid molecule comprising an AVV vector and a promoter operably linked to a sequence encoding BMP-2; and a nucleic acid molecule comprising an Adv vector and a promoter operably linked to a sequence encoding BMP-2, as well as vectors and host cells comprising said nucleic acid molecules, respectively.
Persistent Identifierhttp://hdl.handle.net/10722/177079

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:03Z-
dc.date.available2012-11-30T08:39:03Z-
dc.date.issued2004-
dc.identifier.citationWO Published patent application WO 2004083434. World Intellectual Property Organization (WIPO), PatentScope, 2004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177079-
dc.description.abstractThe present invention provides an efficient gene delivery system using Adeno-Associated Viral (AAV) vector in gene therapy. Furthermore, the invention provides a combined AAV and Adenovirus (Adv) cocktail gene delivery system which is even more efficient in in vivo gene delivery and expression without eliciting any significant immune responses in an immunocompetent subject. In particular, the invention provides a therapeutic agent and methods for preventing, treating, managing, or ameliorating various diseases and disorders including, but not limited to, bone diseases, by delivering Bone Morphogenetic Protein 2 (BMP-2) for new bone formation via gene therapy using said system. The invention provides a nucleic acid molecule comprising an AVV vector and a promoter operably linked to a sequence encoding BMP-2; and a nucleic acid molecule comprising an Adv vector and a promoter operably linked to a sequence encoding BMP-2, as well as vectors and host cells comprising said nucleic acid molecules, respectively.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleA COMBINED ADENO-ASSOCIATED VIRUS AND ADENOVIRUS COCKTAIL GENE DELIVERY SYSTEM FOR HIGH EFFIENCY GENE EXPRESSION WITHOUT ELICITING IMMUNE RESPONSE IN IMMUNO-COMPETENT SUBJECTSen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorChen, Yen_HK
dc.contributor.inventorKung, Hsiangfuen_HK
dc.contributor.inventorLin, MCen_HK
dc.contributor.inventorLuk, KDKen_HK
patents.identifier.applicationPC T/CN2004000209en_HK
patents.description.assigneeUNIV HONG KONG [CN]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication2004-09-30en_HK
patents.date.application2004-03-17en_HK
patents.date.priority2003-03-17 US 10/455188Pen_HK
patents.description.ccWOen_HK
patents.identifier.publicationWO 2004083434en_HK
patents.relation.familyUS 2004223953 (A1) 2004-11-11en_HK
patents.relation.familyWO 2004083434 (A1) 2004-09-30en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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