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  Patent History
  • Application
    US 10/801648 2004-03-17
  • Publication
    US 2004223953 2004-11-11

published patent: Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects

TitleCombined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects
Priority Date2004-03-17 US 10/801648
2003-03-17 US 10/455188P
Inventors
Issue Date2004
Citation
US Published patent application US 2004223953. Washington, DC: US Patent and Trademark Office (USPTO), 2004 How to Cite?
AbstractThe present invention provides an efficient gene delivery system using Adeno-Associated Viral (AAV) vector in gene therapy. Furthermore, the invention provides a combined AAV and Adenovirus (Adv) cocktail gene delivery system which is even more efficient in in vivo gene delivery and expression without eliciting any significant immune responses in an immunocompetent subject. In particular, the invention provides a therapeutic agent and methods for preventing, treating, managing, or ameliorating various diseases and disorders including, but not limited to, bone diseases, by delivering Bone Morphogenetic Protein 2 (BMP-2) for new bone formation via gene therapy using said system. The invention provides a nucleic acid molecule comprising an AVV vector and a promoter operably linked to a sequence encoding BMP-2; and a nucleic acid molecule comprising an Adv vector and a promoter operably linked to a sequence encoding BMP-2, as well as vectors and host cells comprising said nucleic acid molecules, respectively.
Persistent Identifierhttp://hdl.handle.net/10722/176876

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:39Z-
dc.date.available2012-11-30T08:38:39Z-
dc.date.issued2004-
dc.identifier.citationUS Published patent application US 2004223953. Washington, DC: US Patent and Trademark Office (USPTO), 2004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176876-
dc.description.abstractThe present invention provides an efficient gene delivery system using Adeno-Associated Viral (AAV) vector in gene therapy. Furthermore, the invention provides a combined AAV and Adenovirus (Adv) cocktail gene delivery system which is even more efficient in in vivo gene delivery and expression without eliciting any significant immune responses in an immunocompetent subject. In particular, the invention provides a therapeutic agent and methods for preventing, treating, managing, or ameliorating various diseases and disorders including, but not limited to, bone diseases, by delivering Bone Morphogenetic Protein 2 (BMP-2) for new bone formation via gene therapy using said system. The invention provides a nucleic acid molecule comprising an AVV vector and a promoter operably linked to a sequence encoding BMP-2; and a nucleic acid molecule comprising an Adv vector and a promoter operably linked to a sequence encoding BMP-2, as well as vectors and host cells comprising said nucleic acid molecules, respectively.en_HK
dc.relation.isreferencedbyUS 2011104676 (A1) 2011-05-05en_HK
dc.relation.isreferencedbyUS 8124751 (B2) 2012-02-28en_HK
dc.relation.isreferencedbyUS 2010047926 (A1) 2010-02-25en_HK
dc.relation.isreferencedbyUS 8105778 (B2) 2012-01-31en_HK
dc.relation.isreferencedbyUS 2010035233 (A1) 2010-02-11en_HK
dc.relation.isreferencedbyUS 8241854 (B2) 2012-08-14en_HK
dc.relation.isreferencedbyUS 7846428 (B2) 2010-12-07en_HK
dc.relation.isreferencedbyUS 2009093427 (A1) 2009-04-09en_HK
dc.relation.isreferencedbyUS 2007087334 (A1) 2007-04-19en_HK
dc.relation.isreferencedbyUS 7960357 (B2) 2011-06-14en_HK
dc.relation.isreferencedbyKR 100808269 (B1) 2008-02-29en_HK
dc.relation.isreferencedbyKR 20080007832 (A) 2008-01-23en_HK
dc.relation.isreferencedbyUS 2010221232 (A1) 2010-09-02en_HK
dc.relation.isreferencedbyUS 7816140 (B2) 2010-10-19en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleCombined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjectsen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorKung Hsiang-Fuen_HK
dc.contributor.inventorChen, Yen_HK
dc.contributor.inventorLuk, KDKen_HK
dc.contributor.inventorLin, MCen_HK
patents.identifier.applicationUS 10/801648en_HK
patents.description.assigneeKUNG HSIANG-FU, ; CHEN YAN, ; LUK K.D.K, ; LIN MARIE C.Men_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2004-11-11en_HK
patents.date.application2004-03-17en_HK
patents.date.priority2004-03-17 US 10/801648en_HK
patents.date.priority2003-03-17 US 10/455188Pen_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2004223953en_HK
patents.relation.familyUS 2004223953 (A1) 2004-11-11en_HK
patents.relation.familyWO 2004083434 (A1) 2004-09-30en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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