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  Patent History
  • Application
    PC T/CN2003000140 2003-02-24
  • Publication
    WO 2003074545 2003-09-12
Supplementary

published patent: METHOD FOR SYNTHESIZING 5ss, 6ss-EPOXIDES OF STEROIDS BY A HIGHLY ss-SELECTIVE EPOXIDATION OF DELTA5-UNSATURATED STEROIDS CATALYZED BY KETONES

TitleMETHOD FOR SYNTHESIZING 5ss, 6ss-EPOXIDES OF STEROIDS BY A HIGHLY ss-SELECTIVE EPOXIDATION OF DELTA5-UNSATURATED STEROIDS CATALYZED BY KETONES
Priority Date2002-03-06 US 10/091627
Inventors
Issue Date2003
Citation
WO Published patent application WO 2003074545. World Intellectual Property Organization (WIPO), PatentScope, 2003 How to Cite?
AbstractA general, efficient, and environmentally friendly method is provided for producing mostly ss-epoxides of DELTA5-unsaturated steroids using certain ketones as the catalyst along with an oxidizing agent, or by using certain dioxiranes. In another aspect of the invention, a method is provided for producing mostly 5ss, 6ss-epoxides of steroids from DELTA5-unsaturated steroids having a substituent at the 3alpha-position by an epoxidation reaction using a ketone along with an oxidizing agent under conditions effective to generate epoxides, or using a dioxirane under conditions effective to generate epoxides. A whole range of DELTA5-unsaturated steroids, bearing different functional groups such as hydroxy, carbonyl, acetyl of ketal group as well as different side chains, were conveniently converted to the corresponding synthetically and biologically interesting 5ss, 6ss-epoxides with excellent ss-selectivities and high yields.
Persistent Identifierhttp://hdl.handle.net/10722/177065
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:01Z-
dc.date.available2012-11-30T08:39:01Z-
dc.date.issued2003-
dc.identifier.citationWO Published patent application WO 2003074545. World Intellectual Property Organization (WIPO), PatentScope, 2003en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177065-
dc.description.abstractA general, efficient, and environmentally friendly method is provided for producing mostly ss-epoxides of DELTA5-unsaturated steroids using certain ketones as the catalyst along with an oxidizing agent, or by using certain dioxiranes. In another aspect of the invention, a method is provided for producing mostly 5ss, 6ss-epoxides of steroids from DELTA5-unsaturated steroids having a substituent at the 3alpha-position by an epoxidation reaction using a ketone along with an oxidizing agent under conditions effective to generate epoxides, or using a dioxirane under conditions effective to generate epoxides. A whole range of DELTA5-unsaturated steroids, bearing different functional groups such as hydroxy, carbonyl, acetyl of ketal group as well as different side chains, were conveniently converted to the corresponding synthetically and biologically interesting 5ss, 6ss-epoxides with excellent ss-selectivities and high yields.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHOD FOR SYNTHESIZING 5ss, 6ss-EPOXIDES OF STEROIDS BY A HIGHLY ss-SELECTIVE EPOXIDATION OF DELTA5-UNSATURATED STEROIDS CATALYZED BY KETONESen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorYang, Den_HK
dc.contributor.inventorJiao, Guanshengen_HK
patents.identifier.applicationPC T/CN2003000140en_HK
patents.description.assigneeUNIV HONG KONG [CN]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication2003-09-12en_HK
dc.relation.referencesWO 9850409 (A1) 1998-11-12en_HK
patents.identifier.hkutechidChm-2000-00021-2-
patents.date.application2003-02-24en_HK
patents.date.priority2002-03-06 US 10/091627en_HK
patents.description.ccWOen_HK
patents.identifier.publicationWO 2003074545en_HK
patents.relation.familyAU 2003210119 (A1) 2003-09-16en_HK
patents.relation.familyUS 2003018188 (A1) 2003-01-23en_HK
patents.relation.familyUS 6841665 (B2) 2005-01-11en_HK
patents.relation.familyWO 03074545 (A1) 2003-09-12en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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