File Download
  Patent History
  • Application
    US 10/091627 2002-03-06
  • Publication
    US 2003018188 2003-01-23
Supplementary

published patent: Method for synthesizing 5beta, 6beta-epoxides of steroids by a highly beta-selective epoxidation of delta5-unsaturated steroids catalyzed by ketones

TitleMethod for synthesizing 5beta, 6beta-epoxides of steroids by a highly beta-selective epoxidation of delta5-unsaturated steroids catalyzed by ketones
Priority Date2002-03-06 US 10/091627
2001-02-16 US 09/788201
2000-02-18 US 09/183396P
Inventors
Issue Date2003
Citation
US Published patent application US 2003018188. Washington, DC: US Patent and Trademark Office (USPTO), 2003 How to Cite?
AbstractA general, efficient, and environmentally friendly method is provided for producing mostly beta-epoxides of DELTA5-unsaturated steroids using certain ketones as the catalyst along with an oxidizing agent, or by using certain dioxiranes. In another aspect of the invention, a method is provided for producing mostly 5beta,6beta-epoxides of steroids from DELTA5-unsaturated steroids having a substituent at the 3alpha-position by an epoxidation reaction using a ketone along with an oxidizing agent under conditions effective to generate epoxides, or using a dioxirane under conditions effective to generate epoxides.; A whole range of DELTA5-unsaturated steroids, bearing different functional groups such as hydroxy, carbonyl, acetyl or ketal group as well as different side chains, were conveniently converted to the corresponding synthetically and biologically interesting 5beta,6beta-epoxides with excellent beta-selectivities and high yields.
Persistent Identifierhttp://hdl.handle.net/10722/176832

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:33Z-
dc.date.available2012-11-30T08:38:33Z-
dc.date.issued2003-
dc.identifier.citationUS Published patent application US 2003018188. Washington, DC: US Patent and Trademark Office (USPTO), 2003en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176832-
dc.description.abstractA general, efficient, and environmentally friendly method is provided for producing mostly beta-epoxides of DELTA5-unsaturated steroids using certain ketones as the catalyst along with an oxidizing agent, or by using certain dioxiranes. In another aspect of the invention, a method is provided for producing mostly 5beta,6beta-epoxides of steroids from DELTA5-unsaturated steroids having a substituent at the 3alpha-position by an epoxidation reaction using a ketone along with an oxidizing agent under conditions effective to generate epoxides, or using a dioxirane under conditions effective to generate epoxides.; A whole range of DELTA5-unsaturated steroids, bearing different functional groups such as hydroxy, carbonyl, acetyl or ketal group as well as different side chains, were conveniently converted to the corresponding synthetically and biologically interesting 5beta,6beta-epoxides with excellent beta-selectivities and high yields.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMethod for synthesizing 5beta, 6beta-epoxides of steroids by a highly beta-selective epoxidation of delta5-unsaturated steroids catalyzed by ketonesen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorYang, Den_HK
dc.contributor.inventorJiao Guan-Shengen_HK
patents.identifier.applicationUS 10/091627en_HK
patents.description.assigneeYANG DAN, ; JIAO GUAN-SHENG, ; THE UNIVERSITY OF HONG KONGen_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2003-01-23en_HK
patents.date.application2002-03-06en_HK
patents.date.priority2002-03-06 US 10/091627en_HK
patents.date.priority2001-02-16 US 09/788201en_HK
patents.date.priority2000-02-18 US 09/183396Pen_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2003018188en_HK
patents.relation.familyAU 2003210119 (A1) 2003-09-16en_HK
patents.relation.familyUS 2003018188 (A1) 2003-01-23en_HK
patents.relation.familyUS 6841665 (B2) 2005-01-11en_HK
patents.relation.familyWO 03074545 (A1) 2003-09-12en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats