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  Patent History
  • Application
    US 12/3159837 2011-06-14
  • Publication
    US 2012148632 2012-06-14

published patent: METHODS FOR COMPLEX TISSUE ENGINEERING

TitleMETHODS FOR COMPLEX TISSUE ENGINEERING
Priority Date2011-06-14 US 12/3159837
2010-06-15 US 12/354869P
Inventors
Issue Date30-Nov-2012
Citation
US Published patent application US 2012148632. Washington, DC: US Patent and Trademark Office (USPTO), 2012 How to Cite?
AbstractA simple, highly flexible and scalable platform for making functional complex tissues with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naïve subunits, exposing the undifferentiated or naïve subunits to different cell culture environments for induction of differentiation towards different lineages as required by that complex tissue, and combining the then functional subunits with or without the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. The bioengineered tissue graft can then used to replace dysfunctional tissue.
Persistent Identifierhttp://hdl.handle.net/10722/177023

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:57Z-
dc.date.available2012-11-30T08:38:57Z-
dc.date.issued2012-11-30-
dc.identifier.citationUS Published patent application US 2012148632. Washington, DC: US Patent and Trademark Office (USPTO), 2012en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177023-
dc.description.abstractA simple, highly flexible and scalable platform for making functional complex tissues with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naïve subunits, exposing the undifferentiated or naïve subunits to different cell culture environments for induction of differentiation towards different lineages as required by that complex tissue, and combining the then functional subunits with or without the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. The bioengineered tissue graft can then used to replace dysfunctional tissue.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR COMPLEX TISSUE ENGINEERINGen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.hkuros196515-
dc.identifier.hkuros177474-
dc.contributor.inventorChan, BPen_HK
dc.contributor.inventorCheng Hiu Waen_HK
dc.contributor.inventorChik Daniel Tsz Kiten_HK
dc.contributor.inventorCheung, KMCen_HK
dc.contributor.inventorLuk, KDKen_HK
patents.identifier.applicationUS 12/3159837en_HK
patents.description.assigneeUNIV HONG KONG [HK]en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2012-06-14en_HK
patents.identifier.hkutechidME-2010-00362-1-
patents.date.application2011-06-14en_HK
patents.date.priority2011-06-14 US 12/3159837en_HK
patents.date.priority2010-06-15 US 12/354869Pen_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2012148632en_HK
patents.relation.familyUS 2012148632 (A1) 2012-06-14en_HK
patents.relation.familyWO 2011157057 (A1) 2011-12-22en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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