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  Patent History
  • Application
    PC T/CN2011000988 2011-06-15
  • Publication
    WO 2011157057 2011-12-22

published patent: METHODS FOR COMPLEX TISSUE ENGINEERING

TitleMETHODS FOR COMPLEX TISSUE ENGINEERING
Priority Date2010-06-15 US 12/354869P
Inventors
Issue Date2011
Citation
WO Published patent application WO 2011157057. World Intellectual Property Organization (WIPO), PatentScope, 2011 How to Cite?
AbstractA simple, highly flexible and scalable platform for making functional complex tissue with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naive subunits, exposing the undifferentiated or naive subunits to different cell culture environments for induction of differentiation towards different lineages as required by said complex tissue, and combining the then functional subunits solely or with the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. Said bioengineered tissue graft can be used to replace dysfunctional tissue.
Persistent Identifierhttp://hdl.handle.net/10722/177159
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:14Z-
dc.date.available2012-11-30T08:39:14Z-
dc.date.issued2011-
dc.identifier.citationWO Published patent application WO 2011157057. World Intellectual Property Organization (WIPO), PatentScope, 2011en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177159-
dc.description.abstractA simple, highly flexible and scalable platform for making functional complex tissue with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naive subunits, exposing the undifferentiated or naive subunits to different cell culture environments for induction of differentiation towards different lineages as required by said complex tissue, and combining the then functional subunits solely or with the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. Said bioengineered tissue graft can be used to replace dysfunctional tissue.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR COMPLEX TISSUE ENGINEERINGen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.hkuros196517-
dc.contributor.inventorChan, BPen_HK
dc.contributor.inventorCheng, Hiuwaen_HK
dc.contributor.inventorChik, Tszkit, Danielen_HK
dc.contributor.inventorCheung, KMCen_HK
dc.contributor.inventorLuk, Dipkei, Keithen_HK
patents.identifier.applicationPC T/CN2011000988en_HK
patents.description.assigneeUNIV HONG KONG [CN]; CHAN PUI BARBARA [CN]; CHENG HIUWA [CN]; CHIK TSZKIT DANIEL [CN]; CHEUNG MANCHEE KENNETH [CN]; LUK DIPKEI KEITH [CN]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication2011-12-22en_HK
dc.relation.referencesCN 101721748 (A) 2010-06-09en_HK
dc.relation.referencesCN 101439204 (B) 2012-09-05en_HK
dc.relation.referencesCN 101439204 (A) 2009-05-27en_HK
dc.relation.referencesWO 2006079854 (A1) 2006-08-03en_HK
dc.relation.referencesWO 2009142770 (A2) 2009-11-26en_HK
dc.relation.referencesWO 2009142770 (A3) 2010-01-14en_HK
patents.identifier.hkutechidME-2010-00362-2-
patents.identifier.hkutechidME-2010-00362-7-
patents.date.application2011-06-15en_HK
patents.date.priority2010-06-15 US 12/354869Pen_HK
patents.description.ccWOen_HK
patents.identifier.publicationWO 2011157057en_HK
patents.relation.familyUS 2012148632 (A1) 2012-06-14en_HK
patents.relation.familyWO 2011157057 (A1) 2011-12-22en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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