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  Patent History
  • Application
    US 12/645036 2009-12-22
  • Publication
    US 2010098715 2010-04-22

published patent: ANNEXIN II COMPOSITIONS FOR TREATING OR MONITORING INFLAMMATION OR IMMUNE-MEDIATED DISORDERS

TitleANNEXIN II COMPOSITIONS FOR TREATING OR MONITORING INFLAMMATION OR IMMUNE-MEDIATED DISORDERS
Priority Date2009-12-22 US 12/645036
2008-07-14 US 12/172665
Inventors
Issue Date2010
Citation
US Published patent application US 2010098715. Washington, DC: US Patent and Trademark Office (USPTO), 2010 How to Cite?
AbstractMethods and compositions for treating, detecting, diagnosing or assisting in the diagnosis of an inflammatory or immunological disorder are provided. The authors have made the novel discovery that anti-dsDNA antibodies are reactive to cell surface annexin II and through this interaction, anti-dsDNA antibodies are bound and then internalized and translocated into the cytoplasm and/or nucleus where they mediate altered cellular functions. Compositions that inhibit or interfere with the interaction of annexin II with anti-dsDNA antibodies can be used to treat one or more symptoms or pathological processes of an inflammatory or immunological disorder, preferably an auto-immune disorder. Methods for monitoring the progression or severity of an inflammatory or immunological disorder are also provided. In certain embodiments, levels of annexin II and/or anti-dsDNA antibodies, including anti-dsDNA antibodies that can bind to annexin II, are assessed and compared to a reference level of annexin II and/or anti-dsDNA antibodies that corresponds to a specific stage or severity of the disorder.
Persistent Identifierhttp://hdl.handle.net/10722/176996
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:55Z-
dc.date.available2012-11-30T08:38:55Z-
dc.date.issued2010-
dc.identifier.citationUS Published patent application US 2010098715. Washington, DC: US Patent and Trademark Office (USPTO), 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176996-
dc.description.abstractMethods and compositions for treating, detecting, diagnosing or assisting in the diagnosis of an inflammatory or immunological disorder are provided. The authors have made the novel discovery that anti-dsDNA antibodies are reactive to cell surface annexin II and through this interaction, anti-dsDNA antibodies are bound and then internalized and translocated into the cytoplasm and/or nucleus where they mediate altered cellular functions. Compositions that inhibit or interfere with the interaction of annexin II with anti-dsDNA antibodies can be used to treat one or more symptoms or pathological processes of an inflammatory or immunological disorder, preferably an auto-immune disorder. Methods for monitoring the progression or severity of an inflammatory or immunological disorder are also provided. In certain embodiments, levels of annexin II and/or anti-dsDNA antibodies, including anti-dsDNA antibodies that can bind to annexin II, are assessed and compared to a reference level of annexin II and/or anti-dsDNA antibodies that corresponds to a specific stage or severity of the disorder.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleANNEXIN II COMPOSITIONS FOR TREATING OR MONITORING INFLAMMATION OR IMMUNE-MEDIATED DISORDERSen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorChan, DTMen_HK
dc.contributor.inventorYung, SSYen_HK
patents.identifier.applicationUS 12/645036en_HK
patents.description.assigneeUNIV HONG KONGen_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2010-04-22en_HK
dc.relation.referencesUS 2003148298 (A1) 2003-08-07en_HK
patents.identifier.hkutechidMedi-2008-00260-1-
patents.date.application2009-12-22en_HK
patents.date.priority2009-12-22 US 12/645036en_HK
patents.date.priority2008-07-14 US 12/172665en_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2010098715en_HK
patents.relation.familyUS 2010008900 (A1) 2010-01-14en_HK
patents.relation.familyUS 2010098715 (A1) 2010-04-22en_HK
patents.relation.familyWO 2010006501 (A1) 2010-01-21en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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