published patent: COLLAGEN-BASED MICROSPHERES AND METHODS OF PREPARATION AND USE THEREOF

TitleCOLLAGEN-BASED MICROSPHERES AND METHODS OF PREPARATION AND USE THEREOF
Priority Date2008-07-07 PCT/CN2008001277
2007-07-06 US 11/948336P
Inventors
Issue Date2010
Citation
EP Published Patent application EP 2175978. European Patent Office (EPO), Escapenet, 2010 How to Cite?
AbstractA method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation method. The microspheres are photochemically crosslinked to control the release of the bioactive molecules for better drug delivery usage without compromising the biocompatibility of the crosslinked structures. The method uses mild fabrication conditions and simple processes, no toxic chemical crosslinking reagent, which may cause cytotoxicity and calcification after implantation, no organic solvents, which may reduce drug availability and bioactivity, and no vigorous stirring action, which may fragmentize material with poor shape and mechanical stability and thus destabilize the emulsion. The resulting microparticles or microspheres are of controlled size, controlled release, highly biocompatible, and useful for drug delivery as well as cell culture.
Persistent Identifierhttp://hdl.handle.net/10722/176758
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:26Z-
dc.date.available2012-11-30T08:38:26Z-
dc.date.issued2010-
dc.identifier.citationEP Published Patent application EP 2175978. European Patent Office (EPO), Escapenet, 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176758-
dc.description.abstractA method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation method. The microspheres are photochemically crosslinked to control the release of the bioactive molecules for better drug delivery usage without compromising the biocompatibility of the crosslinked structures. The method uses mild fabrication conditions and simple processes, no toxic chemical crosslinking reagent, which may cause cytotoxicity and calcification after implantation, no organic solvents, which may reduce drug availability and bioactivity, and no vigorous stirring action, which may fragmentize material with poor shape and mechanical stability and thus destabilize the emulsion. The resulting microparticles or microspheres are of controlled size, controlled release, highly biocompatible, and useful for drug delivery as well as cell culture.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleCOLLAGEN-BASED MICROSPHERES AND METHODS OF PREPARATION AND USE THEREOFen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorChan, BPen_HK
dc.contributor.inventorChan, Cheukmingen_HK
dc.contributor.inventorSo, KFen_HK
patents.identifier.applicationEP 20080773021en_HK
patents.description.assigneeUNIV HONG KONG [CN]en_HK
patents.description.countryEuropean Patent Officeen_HK
patents.date.publication2010-04-21en_HK
dc.relation.referencesWO 2006029571 (A1) 2006-03-23en_HK
dc.relation.referencesUS 3406119 (A) 1968-10-15en_HK
dc.relation.referencesXP 008045142en_HK
dc.relation.referencesXP 022735034en_HK
dc.relation.referencesXP 008128900en_HK
patents.date.application2008-07-07en_HK
patents.date.priority2008-07-07 PCT/CN2008001277en_HK
patents.date.priority2007-07-06 US 11/948336Pen_HK
patents.description.ccEPen_HK
patents.identifier.publicationEP 2175978en_HK
patents.relation.familyCN 101868298 (A) 2010-10-20en_HK
patents.relation.familyEP 2175978 (A1) 2010-04-21en_HK
patents.relation.familyUS 2006099268 (A1) 2006-05-11en_HK
patents.relation.familyUS 7393437 (B2) 2008-07-01en_HK
patents.relation.familyUS 2008317866 (A1) 2008-12-25en_HK
patents.relation.familyUS 7931918 (B2) 2011-04-26en_HK
patents.relation.familyWO 2006029571 (A1) 2006-03-23en_HK
patents.relation.familyWO 2009006792 (A1) 2009-01-15en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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