published patent: COLLAGEN-BASED MICROSPHERES AND METHODS OF PREPARATION AND USES THEREOF

TitleCOLLAGEN-BASED MICROSPHERES AND METHODS OF PREPARATION AND USES THEREOF
Priority Date2008-07-02 US 12/166670
2005-09-14 US 11/225108
2007-07-06 US 11/948336P
2004-09-14 US 10/609600P
Inventors
Issue Date2008
Citation
US Published patent application US 2008317866. Washington, DC: US Patent and Trademark Office (USPTO), 2008 How to Cite?
AbstractA method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation method. The microspheres are photochemically crosslinked to control the release of the bioactive molecules for better drug delivery usage without compromising the biocompatibility of the crosslinked structures. The method uses mild fabrication conditions and simple processes, no toxic chemical crosslinking reagent, which may cause cytotoxicity and calcification after implantation, no organic solvents, which may reduce drug availability and bioactivity, and no vigorous stirring action, which may fragmentize material with poor shape and mechanical stability and thus destabilize the emulsion.; The resulting microparticles or microspheres are of controlled size, controlled release, highly biocompatible, and useful for drug delivery as well as cell culture.
Persistent Identifierhttp://hdl.handle.net/10722/176970

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:52Z-
dc.date.available2012-11-30T08:38:52Z-
dc.date.issued2008-
dc.identifier.citationUS Published patent application US 2008317866. Washington, DC: US Patent and Trademark Office (USPTO), 2008en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176970-
dc.description.abstractA method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation method. The microspheres are photochemically crosslinked to control the release of the bioactive molecules for better drug delivery usage without compromising the biocompatibility of the crosslinked structures. The method uses mild fabrication conditions and simple processes, no toxic chemical crosslinking reagent, which may cause cytotoxicity and calcification after implantation, no organic solvents, which may reduce drug availability and bioactivity, and no vigorous stirring action, which may fragmentize material with poor shape and mechanical stability and thus destabilize the emulsion.; The resulting microparticles or microspheres are of controlled size, controlled release, highly biocompatible, and useful for drug delivery as well as cell culture.en_HK
dc.relation.isreferencedbyWO 2012050879 (A3) 2012-06-07en_HK
dc.relation.isreferencedbyWO 2012050879 (A2) 2012-04-19en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleCOLLAGEN-BASED MICROSPHERES AND METHODS OF PREPARATION AND USES THEREOFen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.hkuros152389-
dc.contributor.inventorChan, BPen_HK
dc.contributor.inventorChan Cheuk Mingen_HK
dc.contributor.inventorSo, KFen_HK
patents.identifier.applicationUS 12/166670en_HK
patents.description.assigneeUNIV HONG KONGen_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2008-12-25en_HK
patents.date.application2008-07-02en_HK
patents.date.priority2008-07-02 US 12/166670en_HK
patents.date.priority2005-09-14 US 11/225108en_HK
patents.date.priority2007-07-06 US 11/948336Pen_HK
patents.date.priority2004-09-14 US 10/609600Pen_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2008317866en_HK
patents.relation.familyCN 101868298 (A) 2010-10-20en_HK
patents.relation.familyEP 2175978 (A1) 2010-04-21en_HK
patents.relation.familyUS 2006099268 (A1) 2006-05-11en_HK
patents.relation.familyUS 7393437 (B2) 2008-07-01en_HK
patents.relation.familyUS 2008317866 (A1) 2008-12-25en_HK
patents.relation.familyUS 7931918 (B2) 2011-04-26en_HK
patents.relation.familyWO 2006029571 (A1) 2006-03-23en_HK
patents.relation.familyWO 2009006792 (A1) 2009-01-15en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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