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Article: Long-term renal allograft recipients from South-east Asia in the pre- cyclosporin era

TitleLong-term renal allograft recipients from South-east Asia in the pre- cyclosporin era
Authors
KeywordsComplications
Immunosuppression
Morbidity
Mortality
Renal transplantation
Issue Date1999
PublisherWichtig Editore srl. The Journal's web site is located at http://www.artificial-organs.com
Citation
International Journal Of Artificial Organs, 1999, v. 22 n. 3, p. 131-137 How to Cite?
AbstractThe clinical outcome of long-term renal allograft recipients in the Chinese population has not been reported previously. We analysed patients from the pre-cyclosporin era who had grafts that functioned for > 10 years. Forty-five patients (31 men, 14 women; mean age 30, follow-up duration 13.3 years), representing a 10-year graft survival of 53%, were included. Thirty- six patients (80%) received living-related allografts and 9 (20%) received cadaveric or living-unrelated renal transplantation. The mean serum creatinine at last follow-up was 1.36 mg/dl (range, 0.83-4.08). Major posttransplantation complications included: hypertension in 25 (56%), infection in 16 (36%), acute rejection in 15 (33%), lipid disorder in 13 (29%), liver disease in 7 (16%), osteonecrosis in 5 (11%), malignancy in 4 (9%), coronary artery disease in 3 (7%), and diabetes mellitus in 3 (7%). Five grafts were lost: 3 to chronic rejection, and 2 to patients with stable function who died of non-renal causes. Proteinuria correlated strongly with graft function and survival, and marginally with hypertension. In hepatitis B carriers, serum α-feto protein is useful in the early detection of hepatocellular carcinoma. We conclude that while patients in the pre- cyclosporin era can survive with excellent graft function beyond the first decade, the risk of complications leading to significant morbidity still remains even when patients are receiving minimal doses of immunosuppression in the second decade.
Persistent Identifierhttp://hdl.handle.net/10722/162321
ISSN
2015 Impact Factor: 1.005
2015 SCImago Journal Rankings: 0.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, Sen_HK
dc.contributor.authorLui, SLen_HK
dc.contributor.authorLi, FKen_HK
dc.contributor.authorLo, WKen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2012-09-05T05:18:57Z-
dc.date.available2012-09-05T05:18:57Z-
dc.date.issued1999en_HK
dc.identifier.citationInternational Journal Of Artificial Organs, 1999, v. 22 n. 3, p. 131-137en_HK
dc.identifier.issn0391-3988en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162321-
dc.description.abstractThe clinical outcome of long-term renal allograft recipients in the Chinese population has not been reported previously. We analysed patients from the pre-cyclosporin era who had grafts that functioned for > 10 years. Forty-five patients (31 men, 14 women; mean age 30, follow-up duration 13.3 years), representing a 10-year graft survival of 53%, were included. Thirty- six patients (80%) received living-related allografts and 9 (20%) received cadaveric or living-unrelated renal transplantation. The mean serum creatinine at last follow-up was 1.36 mg/dl (range, 0.83-4.08). Major posttransplantation complications included: hypertension in 25 (56%), infection in 16 (36%), acute rejection in 15 (33%), lipid disorder in 13 (29%), liver disease in 7 (16%), osteonecrosis in 5 (11%), malignancy in 4 (9%), coronary artery disease in 3 (7%), and diabetes mellitus in 3 (7%). Five grafts were lost: 3 to chronic rejection, and 2 to patients with stable function who died of non-renal causes. Proteinuria correlated strongly with graft function and survival, and marginally with hypertension. In hepatitis B carriers, serum α-feto protein is useful in the early detection of hepatocellular carcinoma. We conclude that while patients in the pre- cyclosporin era can survive with excellent graft function beyond the first decade, the risk of complications leading to significant morbidity still remains even when patients are receiving minimal doses of immunosuppression in the second decade.en_HK
dc.languageengen_US
dc.publisherWichtig Editore srl. The Journal's web site is located at http://www.artificial-organs.comen_HK
dc.relation.ispartofInternational Journal of Artificial Organsen_HK
dc.subjectComplicationsen_HK
dc.subjectImmunosuppressionen_HK
dc.subjectMorbidityen_HK
dc.subjectMortalityen_HK
dc.subjectRenal transplantationen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Distributionen_US
dc.subject.meshChinaen_US
dc.subject.meshCyclosporinsen_US
dc.subject.meshEvaluation Studies As Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGraft Rejectionen_US
dc.subject.meshGraft Survivalen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agentsen_US
dc.subject.meshKidney Failure, Chronic - Surgeryen_US
dc.subject.meshKidney Transplantation - Adverse Effects - Immunology - Mortalityen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPregnancyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Distributionen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTransplantation Immunologyen_US
dc.subject.meshTransplantation, Homologous - Immunology - Mortalityen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleLong-term renal allograft recipients from South-east Asia in the pre- cyclosporin eraen_HK
dc.typeArticleen_HK
dc.identifier.emailTang, S: scwtang@hku.hken_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, S=rp00480en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10357240-
dc.identifier.scopuseid_2-s2.0-0032960317en_HK
dc.identifier.hkuros41548-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032960317&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue3en_HK
dc.identifier.spage131en_HK
dc.identifier.epage137en_HK
dc.identifier.isiWOS:000080148900004-
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridTang, S=7403437082en_HK
dc.identifier.scopusauthoridLui, SL=7102379130en_HK
dc.identifier.scopusauthoridLi, FK=8219093900en_HK
dc.identifier.scopusauthoridLo, WK=7201502414en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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