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Article: The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: A long-term prospective study

TitleThe KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: A long-term prospective study
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 12, article no. e28598 How to Cite?
AbstractContext: The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. Objective: This study aimed to evaluate whether the E23K variant could predict glycaemic progression in a Southern Chinese population. Methods/Principal Findings: We performed a long-term prospective study on 1912 subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS). The KCNJ11 E23K variant was associated with the progression to prediabetes after a median interval of 12 years on multinomial logistic regression analysis, even after adjustment for traditional risk factors (OR 1.29, P age, sex, BMI and fasting plasma glucose [FPG] adjusted = 0.02). Based on Cox proportional hazard regression analysis, the E23K variant also predicted incident prediabetes (HR 1.18, P age, sex, BMI and FPG adjusted = 0.021). However, E23K was not associated with the progression to T2DM in either multinomial or Cox regression analysis, and the association of E23K with glycaemic progression to either prediabetes or T2DM was significant only in unadjusted Cox regression analysis (P = 0.039). In a meta-analysis of eight prospective studies including our own, involving 15680 subjects, the E23K variant was associated with incident T2DM (fixed effect: OR 1.10, P = 4×10 -3; random effect: OR 1.11, P = 0.035). Conclusions: Our study has provided supporting evidence for the role of the E23K variant in glycaemic progression in Chinese, with its effect being more evident in the early stage of T2DM, as the subjects progressed from normal glucose tolerance to prediabetes. © 2011 Cheung et al.
Persistent Identifierhttp://hdl.handle.net/10722/159664
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CYYen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorFong, CHYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorLaw, LSCen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2012-08-16T05:53:50Z-
dc.date.available2012-08-16T05:53:50Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 12, article no. e28598en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159664-
dc.description.abstractContext: The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. Objective: This study aimed to evaluate whether the E23K variant could predict glycaemic progression in a Southern Chinese population. Methods/Principal Findings: We performed a long-term prospective study on 1912 subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS). The KCNJ11 E23K variant was associated with the progression to prediabetes after a median interval of 12 years on multinomial logistic regression analysis, even after adjustment for traditional risk factors (OR 1.29, P age, sex, BMI and fasting plasma glucose [FPG] adjusted = 0.02). Based on Cox proportional hazard regression analysis, the E23K variant also predicted incident prediabetes (HR 1.18, P age, sex, BMI and FPG adjusted = 0.021). However, E23K was not associated with the progression to T2DM in either multinomial or Cox regression analysis, and the association of E23K with glycaemic progression to either prediabetes or T2DM was significant only in unadjusted Cox regression analysis (P = 0.039). In a meta-analysis of eight prospective studies including our own, involving 15680 subjects, the E23K variant was associated with incident T2DM (fixed effect: OR 1.10, P = 4×10 -3; random effect: OR 1.11, P = 0.035). Conclusions: Our study has provided supporting evidence for the role of the E23K variant in glycaemic progression in Chinese, with its effect being more evident in the early stage of T2DM, as the subjects progressed from normal glucose tolerance to prediabetes. © 2011 Cheung et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshDiabetes Mellitus, Type 2 - diagnosis - ethnology - genetics-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshPotassium Channels, Inwardly Rectifying - genetics-
dc.subject.meshPrediabetic State - diagnosis - ethnology - genetics-
dc.titleThe KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: A long-term prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0028598en_HK
dc.identifier.pmid22163043-
dc.identifier.pmcidPMC3230634-
dc.identifier.scopuseid_2-s2.0-82655180445en_HK
dc.identifier.hkuros204116en_US
dc.identifier.hkuros213326-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-82655180445&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue12en_HK
dc.identifier.isiWOS:000298172800053-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, CYY=36022243200en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridFong, CHY=14033917100en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridLaw, LSC=36994511000en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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