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Article: Plasma amyloid-β oligomers level is a biomarker for Alzheimer's disease diagnosis

TitlePlasma amyloid-β oligomers level is a biomarker for Alzheimer's disease diagnosis
Authors
KeywordsAmyloid beta protein
Abbreviated Metal Test
Alzheimers Disease Assessment Scale Cognitive Subscale
Enzyme linked immunosorbent assay
Protein blood level
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical and Biophysical Research Communications, 2012, v. 423 n. 4, p. 697-702 How to Cite?
AbstractAmyloid beta (Abeta), especially Abeta oligomers, is important in Alzheimer's disease (AD) pathogenesis. We studied plasma Abeta(40), Abeta(42), and Abeta oligomers levels in 44 AD patients and 22 non-demented controls. Cognitive functions were assessed by Chinese version of mini-mental state examination (MMSE), Abbreviated Metal Test (AMT), Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-cog). Plasma Abeta monomers and oligomers levels were measured by ELISA. We found that the median plasma Abeta(40) and Abeta(42) levels were similar between AD and controls, and without significant correlation with cognition. Plasma Abeta oligomers level was higher in AD than controls (642.54ng/ml [range 103.33-2676.93] versus 444.18ng/ml [range 150.19-1311.18], p=0.047), and negatively correlated with cognition. In multivariate logistic regression analysis, the highest tertile of Abeta oligomers levels showed an increased risk of AD than the combined group of middle and lowest tertiles (OR=8.85, p=0.013), after adjustment of gender, age and APOE4 genotype. Increased plasma Abeta oligomers level was associated with decreased MMSE and AMT scores (p=0.037, p=0.043, respectively) and increased ADAS-cog score (p=0.036), suggesting negative correlation with cognitive function. We concluded that plasma Abeta oligomers level is an useful biomarker for AD diagnosis.
Persistent Identifierhttp://hdl.handle.net/10722/149064
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Len_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorChu, LWen_US
dc.contributor.authorKwan, JSCen_US
dc.contributor.authorSong, YQen_US
dc.contributor.authorChen, LHen_US
dc.contributor.authorHo, PWLen_US
dc.contributor.authorCheng, OYen_US
dc.contributor.authorHo, JWMen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2012-06-22T06:19:40Z-
dc.date.available2012-06-22T06:19:40Z-
dc.date.issued2012en_US
dc.identifier.citationBiochemical and Biophysical Research Communications, 2012, v. 423 n. 4, p. 697-702en_US
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10722/149064-
dc.description.abstractAmyloid beta (Abeta), especially Abeta oligomers, is important in Alzheimer's disease (AD) pathogenesis. We studied plasma Abeta(40), Abeta(42), and Abeta oligomers levels in 44 AD patients and 22 non-demented controls. Cognitive functions were assessed by Chinese version of mini-mental state examination (MMSE), Abbreviated Metal Test (AMT), Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-cog). Plasma Abeta monomers and oligomers levels were measured by ELISA. We found that the median plasma Abeta(40) and Abeta(42) levels were similar between AD and controls, and without significant correlation with cognition. Plasma Abeta oligomers level was higher in AD than controls (642.54ng/ml [range 103.33-2676.93] versus 444.18ng/ml [range 150.19-1311.18], p=0.047), and negatively correlated with cognition. In multivariate logistic regression analysis, the highest tertile of Abeta oligomers levels showed an increased risk of AD than the combined group of middle and lowest tertiles (OR=8.85, p=0.013), after adjustment of gender, age and APOE4 genotype. Increased plasma Abeta oligomers level was associated with decreased MMSE and AMT scores (p=0.037, p=0.043, respectively) and increased ADAS-cog score (p=0.036), suggesting negative correlation with cognitive function. We concluded that plasma Abeta oligomers level is an useful biomarker for AD diagnosis.-
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description-
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subjectAmyloid beta protein-
dc.subjectAbbreviated Metal Test-
dc.subjectAlzheimers Disease Assessment Scale Cognitive Subscale-
dc.subjectEnzyme linked immunosorbent assay-
dc.subjectProtein blood level-
dc.titlePlasma amyloid-β oligomers level is a biomarker for Alzheimer's disease diagnosisen_US
dc.typeArticleen_US
dc.identifier.emailChan, KH: koonho@hku.hken_US
dc.identifier.emailChu, LW: lwchu@hkucc.hku.hken_US
dc.identifier.emailKwan, JSC: jsckwan@hkucc.hku.hken_US
dc.identifier.emailSong, YQ: songy@hku.hken_US
dc.identifier.emailHo, PWL: hwl2002@hku.hken_US
dc.identifier.emailCheng, OY: onyin@hku.hken_US
dc.identifier.emailHo, JWM: seeka@hku.hken_US
dc.identifier.emailLam, KSL: ksllam@hku.hken_US
dc.identifier.authorityChan, KH=rp00537en_US
dc.identifier.authoritySong, Y=rp00488en_US
dc.identifier.authorityHo, WL=rp00259en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2012.06.017-
dc.identifier.pmid22704931-
dc.identifier.scopuseid_2-s2.0-84863812366-
dc.identifier.hkuros200454en_US
dc.identifier.volume423-
dc.identifier.issue4-
dc.identifier.spage697-
dc.identifier.epage702-
dc.identifier.isiWOS:000307032400014-
dc.publisher.placeUnited States-
dc.identifier.citeulike10785636-

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