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Article: Apoptotic and proliferative activity in ovarian benign, borderline and malignant tumors.

TitleApoptotic and proliferative activity in ovarian benign, borderline and malignant tumors.
Authors
Issue Date2002
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10019294.asp
Citation
Chinese Medical Sciences Journal = Chung-Kuo I Hsueh K'o Hsueh Tsa Chih / Chinese Academy Of Medical Sciences, 2002, v. 17 n. 2, p. 106-111 How to Cite?
AbstractOBJECTIVE: To determine the apoptotic and proliferative activities in various ovarian epithelial tumors. METHODS: Formalin-fixed, paraffin-embedded tissues of 86 ovarian epithelial tumors, including 52 adenocarcinomas, 23 borderline tumors and 11 cystadenoma, were retrieved. Apoptotic (AI) and proliferative (PI) index were estimated using the monoclonal antibodies: M30, Ki-67 and Ki-S1 in these tumors. Quantitative assessment of AI and PI was estimated by calculating the percentage of positive cells among no less than 1000 tumor cells. RESULTS: Statistically significant difference in AI was found between benign and borderline tumors or carcinomas (P = 0.028, 0.001, respectively). Significant differences in PI, as assessed by both Ki-67 and topo IIalpha, were demonstrated between carcinomas and benign or borderline tumors (both P < 0.001). Benign tumors had both low PI and AI; borderline tumors had lower PI but higher AI, while adenocarcinomas had both high proliferative and high apoptotic rates. Among borderline tumors, serious tumors had significantly lower AI and higher PI than mucinous ones. CONCLUSION: The results suggest that apoptotic and proliferative activities play important roles in the pathogenesis and development of ovarian borderline and malignant tumors. The high apoptotic rate in borderline tumor may explain its relatively indolent behavior while the high proliferative rate in carcinomas tends to explain its aggressive behavior.
Persistent Identifierhttp://hdl.handle.net/10722/148398
ISSN
2015 SCImago Journal Rankings: 0.272

 

DC FieldValueLanguage
dc.contributor.authorLiu, Aen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorNgan, HYen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorZhao, Yen_HK
dc.contributor.authorCheung, ANen_HK
dc.date.accessioned2012-05-29T06:12:43Z-
dc.date.available2012-05-29T06:12:43Z-
dc.date.issued2002en_HK
dc.identifier.citationChinese Medical Sciences Journal = Chung-Kuo I Hsueh K'o Hsueh Tsa Chih / Chinese Academy Of Medical Sciences, 2002, v. 17 n. 2, p. 106-111en_HK
dc.identifier.issn1001-9294en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148398-
dc.description.abstractOBJECTIVE: To determine the apoptotic and proliferative activities in various ovarian epithelial tumors. METHODS: Formalin-fixed, paraffin-embedded tissues of 86 ovarian epithelial tumors, including 52 adenocarcinomas, 23 borderline tumors and 11 cystadenoma, were retrieved. Apoptotic (AI) and proliferative (PI) index were estimated using the monoclonal antibodies: M30, Ki-67 and Ki-S1 in these tumors. Quantitative assessment of AI and PI was estimated by calculating the percentage of positive cells among no less than 1000 tumor cells. RESULTS: Statistically significant difference in AI was found between benign and borderline tumors or carcinomas (P = 0.028, 0.001, respectively). Significant differences in PI, as assessed by both Ki-67 and topo IIalpha, were demonstrated between carcinomas and benign or borderline tumors (both P < 0.001). Benign tumors had both low PI and AI; borderline tumors had lower PI but higher AI, while adenocarcinomas had both high proliferative and high apoptotic rates. Among borderline tumors, serious tumors had significantly lower AI and higher PI than mucinous ones. CONCLUSION: The results suggest that apoptotic and proliferative activities play important roles in the pathogenesis and development of ovarian borderline and malignant tumors. The high apoptotic rate in borderline tumor may explain its relatively indolent behavior while the high proliferative rate in carcinomas tends to explain its aggressive behavior.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10019294.aspen_HK
dc.relation.ispartofChinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih / Chinese Academy of Medical Sciencesen_HK
dc.subject.meshAntigens, Neoplasmen_US
dc.subject.meshApoptosisen_US
dc.subject.meshCarcinoma, Endometrioid - Chemistry - Pathologyen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCystadenocarcinoma, Serous - Chemistry - Pathologyen_US
dc.subject.meshCystadenoma, Mucinous - Chemistry - Pathologyen_US
dc.subject.meshCystadenoma, Serous - Chemistry - Pathologyen_US
dc.subject.meshDna Topoisomerases, Type Ii - Analysisen_US
dc.subject.meshDna-Binding Proteinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKi-67 Antigen - Analysisen_US
dc.subject.meshOvarian Neoplasms - Chemistry - Pathologyen_US
dc.titleApoptotic and proliferative activity in ovarian benign, borderline and malignant tumors.en_HK
dc.typeArticleen_HK
dc.identifier.emailNgan, HY:hysngan@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.emailCheung, AN:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityNgan, HY=rp00346en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityCheung, AN=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12906164-
dc.identifier.scopuseid_2-s2.0-1542751233en_HK
dc.identifier.hkuros83967-
dc.identifier.volume17en_HK
dc.identifier.issue2en_HK
dc.identifier.spage106en_HK
dc.identifier.epage111en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiu, A=16068923700en_HK
dc.identifier.scopusauthoridChen, L=7409435118en_HK
dc.identifier.scopusauthoridNgan, HY=34571944100en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridZhao, Y=15833701000en_HK
dc.identifier.scopusauthoridCheung, AN=54927484100en_HK

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