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Article: Risk factors for distant recurrence of hepatocellular carcinoma in the liver after complete coagulation by microwave or radiofrequency ablation

TitleRisk factors for distant recurrence of hepatocellular carcinoma in the liver after complete coagulation by microwave or radiofrequency ablation
Authors
KeywordsHepatitis C virus
Hepatocellular carcinoma
Microwave coagulation
Radiofrequency ablation
Recurrence of HCC
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2001, v. 91 n. 5, p. 949-956 How to Cite?
AbstractBACKGROUND. In patients with hepatocellular carcinoma (HCC), recurrences in the distant liver often are observed after curative treatment. Microwave coagulation therapy (MCT) and radio-frequency ablation [RFA] have been developed as less invasive alternatives than surgical resection for small HCCs. In the current study, risk factors for distant recurrence of HCC were analyzed in patients in whom complete coagulation was achieved. METHODS. Ninety-two patients with HCCs < 3 cm in greatest dimension were treated by MCT or RFA percutaneously or laparoscopically. Eighty-four patients in whom complete coagulation was achieved without recurrence in the same subsegment as the primary nodule were included in this study. Distant recurrences were observed in 22 patients. Fifteen possible risk factors for a distant recurrence were analyzed. RESULTS. When comparing the patients with a recurrence of HCC nodules in the remnant liver to those without recurrence, the authors observed a statistically significant difference only in serum α-fetoprotein. The distant recurrence-free survival was analyzed by the Kaplan-Meier method. A statistically significant difference was observed in hepatitis C virus (HCV) infection as an etiopathic agent of underlying liver diseases (P < 0.005) and in the number of the primary HCC nodules (P < 0.05, log-rank test). A multivariate step-wise Cox hazard model revealed that HCV infection and the number of primary HCC nodules were statistically independent risk factors. CONCLUSIONS. Patients who had more than two HCC nodules accompanied by HCV infection had a high incidence of recurrence of HCC in the remnant liver. Even when coagulation by microwave or ablation by radio-frequency was complete. © 2001 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/148246
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShen, DHen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorXue, WCen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorLiuwang, Jen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorChan, YKen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2012-05-29T06:11:46Z-
dc.date.available2012-05-29T06:11:46Z-
dc.date.issued2001en_HK
dc.identifier.citationCancer, 2001, v. 91 n. 5, p. 949-956en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/148246-
dc.description.abstractBACKGROUND. In patients with hepatocellular carcinoma (HCC), recurrences in the distant liver often are observed after curative treatment. Microwave coagulation therapy (MCT) and radio-frequency ablation [RFA] have been developed as less invasive alternatives than surgical resection for small HCCs. In the current study, risk factors for distant recurrence of HCC were analyzed in patients in whom complete coagulation was achieved. METHODS. Ninety-two patients with HCCs < 3 cm in greatest dimension were treated by MCT or RFA percutaneously or laparoscopically. Eighty-four patients in whom complete coagulation was achieved without recurrence in the same subsegment as the primary nodule were included in this study. Distant recurrences were observed in 22 patients. Fifteen possible risk factors for a distant recurrence were analyzed. RESULTS. When comparing the patients with a recurrence of HCC nodules in the remnant liver to those without recurrence, the authors observed a statistically significant difference only in serum α-fetoprotein. The distant recurrence-free survival was analyzed by the Kaplan-Meier method. A statistically significant difference was observed in hepatitis C virus (HCV) infection as an etiopathic agent of underlying liver diseases (P < 0.005) and in the number of the primary HCC nodules (P < 0.05, log-rank test). A multivariate step-wise Cox hazard model revealed that HCV infection and the number of primary HCC nodules were statistically independent risk factors. CONCLUSIONS. Patients who had more than two HCC nodules accompanied by HCV infection had a high incidence of recurrence of HCC in the remnant liver. Even when coagulation by microwave or ablation by radio-frequency was complete. © 2001 American Cancer Society.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.subjectHepatitis C virusen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectMicrowave coagulationen_HK
dc.subjectRadiofrequency ablationen_HK
dc.subjectRecurrence of HCCen_HK
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Hepatocellular - Pathology - Surgeryen_US
dc.subject.meshCatheter Ablationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis C - Complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshLaparoscopyen_US
dc.subject.meshLiver Neoplasms - Pathology - Surgeryen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrowaves - Therapeutic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Recurrence, Localen_US
dc.subject.meshRadio Wavesen_US
dc.subject.meshRisk Factorsen_US
dc.titleRisk factors for distant recurrence of hepatocellular carcinoma in the liver after complete coagulation by microwave or radiofrequency ablationen_HK
dc.typeArticleen_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0142(20010301)91:5<949::AID-CNCR1084>3.0.CO;2-Hen_HK
dc.identifier.pmid11251946-
dc.identifier.scopuseid_2-s2.0-0035281547en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035281547&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue5en_HK
dc.identifier.spage949en_HK
dc.identifier.epage956en_HK
dc.identifier.isiWOS:000167348200008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShen, DH=7401738584en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridXue, WC=7103165268en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridLiuwang, J=23106561900en_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridChan, YK=23105150000en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK

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