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Article: Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer

TitleSomatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer
Authors
KeywordsBRCA1
Breast cancer
Chinese
Ovarian cancer
Somatic mutations
Issue Date1999
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1999, v. 18 n. 32, p. 4643-4646 How to Cite?
AbstractInherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investigate the contribution of BRCA1 mutations to sporadic breast and ovarian cancer in the Chinese population, we analysed 62 samples from Chinese women using the protein truncation test. There were 40 cases of breast cancer under age 50 and 22 cases of ovarian cancer, all unselected for family history. There was no age selection for the ovarian cancers. We found two somatic BRCA1 mutations in exon 11, one in a breast cancer and the other in an ovarian cancer, both of which result in truncated proteins. Our results indicate that somatic BRCA1 mutations, like somatic mutations in the BRCA2 gene, though very rare, can be found in both breast and ovarian cancers and support a tumor suppressor function for BRCA1 in sporadic tumors.
Persistent Identifierhttp://hdl.handle.net/10722/148177
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorOzcelik, Hen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorChow, LWCen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorDone, SJen_HK
dc.contributor.authorLiang, ACTen_HK
dc.contributor.authorChan, VWYen_HK
dc.contributor.authorAu, GKHen_HK
dc.contributor.authorNg, WFen_HK
dc.contributor.authorPoon, CSPen_HK
dc.contributor.authorLeung, YFen_HK
dc.contributor.authorLoong, Fen_HK
dc.contributor.authorIp, Pen_HK
dc.contributor.authorChan, GSWen_HK
dc.contributor.authorAndrulis, ILen_HK
dc.contributor.authorJing, Len_HK
dc.contributor.authorHo, FCSen_HK
dc.date.accessioned2012-05-29T06:11:16Z-
dc.date.available2012-05-29T06:11:16Z-
dc.date.issued1999en_HK
dc.identifier.citationOncogene, 1999, v. 18 n. 32, p. 4643-4646en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148177-
dc.description.abstractInherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investigate the contribution of BRCA1 mutations to sporadic breast and ovarian cancer in the Chinese population, we analysed 62 samples from Chinese women using the protein truncation test. There were 40 cases of breast cancer under age 50 and 22 cases of ovarian cancer, all unselected for family history. There was no age selection for the ovarian cancers. We found two somatic BRCA1 mutations in exon 11, one in a breast cancer and the other in an ovarian cancer, both of which result in truncated proteins. Our results indicate that somatic BRCA1 mutations, like somatic mutations in the BRCA2 gene, though very rare, can be found in both breast and ovarian cancers and support a tumor suppressor function for BRCA1 in sporadic tumors.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subjectBRCA1en_HK
dc.subjectBreast canceren_HK
dc.subjectChineseen_HK
dc.subjectOvarian canceren_HK
dc.subjectSomatic mutationsen_HK
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBrca1 Protein - Geneticsen_US
dc.subject.meshBreast Neoplasms - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshOvarian Neoplasms - Geneticsen_US
dc.titleSomatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian canceren_HK
dc.typeArticleen_HK
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.onc.1202847en_HK
dc.identifier.pmid10467410-
dc.identifier.scopuseid_2-s2.0-0033549878en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033549878&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue32en_HK
dc.identifier.spage4643en_HK
dc.identifier.epage4646en_HK
dc.identifier.isiWOS:000082018600015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridOzcelik, H=7003751595en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridChow, LWC=7202532995en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridDone, SJ=7006099450en_HK
dc.identifier.scopusauthoridLiang, ACT=14825292900en_HK
dc.identifier.scopusauthoridChan, VWY=36896382500en_HK
dc.identifier.scopusauthoridAu, GKH=7003748615en_HK
dc.identifier.scopusauthoridNg, WF=25940213100en_HK
dc.identifier.scopusauthoridPoon, CSP=7202672697en_HK
dc.identifier.scopusauthoridLeung, YF=7201463900en_HK
dc.identifier.scopusauthoridLoong, F=6602794154en_HK
dc.identifier.scopusauthoridIp, P=7003622683en_HK
dc.identifier.scopusauthoridChan, GSW=7202355321en_HK
dc.identifier.scopusauthoridAndrulis, IL=7005655442en_HK
dc.identifier.scopusauthoridJing, L=36800123300en_HK
dc.identifier.scopusauthoridHo, FCS=7103408147en_HK

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