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Article: The expression of cathepsin D, oestrogen receptor and progestogen receptor in hydatidiform mole - An immunohistochemical study

TitleThe expression of cathepsin D, oestrogen receptor and progestogen receptor in hydatidiform mole - An immunohistochemical study
Authors
KeywordsCathepsin D
Hormone receptors
Hydatidiform mole
Issue Date1995
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 1995, v. 27 n. 4, p. 341-347 How to Cite?
AbstractThe expression of oestrogen and progestogen receptors, as well as Cathepsin D, an oestrogen-induced protease, in trophoblastic cells of 12 cases of complete hydatidiform mole, 12 cases of partial mole and nine cases of spontaneous abortions, were studied in an attempt to elucidate their possible roles in the pathogenesis of the diseases. The immunohistochemical studies were performed on formalin-fixed paraffin-embedded tissue using the ABC immunoperoxidase method. The intensity of staining and proportion of cells stained were assessed and compared in the three categories of lesions. Immunoreactivity for Cathepsin D was noted in both the syncytio- and cytotrophoblastic cells in all three lesions. Statistical analysis showed consistently stronger and more extensive staining for Cathepsin D in complete moles when compared with abortions. Staining for oestrogen and progestogen receptors was found to be weak in the tissues studied. The strong expression of Cathepsin D in trophoblastic cells of all three lesions, especially in complete mole, suggests that it might be important in the control of trophoblastic cell activities and involved in the pathogenesis of hydatidiform mole. The associated weak expression of sex hormone receptors also suggests that the expression of Cathepsin D in trophoblastic cells may be controlled by modes of regulation other than sex hormones.
Persistent Identifierhttp://hdl.handle.net/10722/148039
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorNg, WFen_HK
dc.contributor.authorKhoo, USen_HK
dc.date.accessioned2012-05-29T06:10:31Z-
dc.date.available2012-05-29T06:10:31Z-
dc.date.issued1995en_HK
dc.identifier.citationHistopathology, 1995, v. 27 n. 4, p. 341-347en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148039-
dc.description.abstractThe expression of oestrogen and progestogen receptors, as well as Cathepsin D, an oestrogen-induced protease, in trophoblastic cells of 12 cases of complete hydatidiform mole, 12 cases of partial mole and nine cases of spontaneous abortions, were studied in an attempt to elucidate their possible roles in the pathogenesis of the diseases. The immunohistochemical studies were performed on formalin-fixed paraffin-embedded tissue using the ABC immunoperoxidase method. The intensity of staining and proportion of cells stained were assessed and compared in the three categories of lesions. Immunoreactivity for Cathepsin D was noted in both the syncytio- and cytotrophoblastic cells in all three lesions. Statistical analysis showed consistently stronger and more extensive staining for Cathepsin D in complete moles when compared with abortions. Staining for oestrogen and progestogen receptors was found to be weak in the tissues studied. The strong expression of Cathepsin D in trophoblastic cells of all three lesions, especially in complete mole, suggests that it might be important in the control of trophoblastic cell activities and involved in the pathogenesis of hydatidiform mole. The associated weak expression of sex hormone receptors also suggests that the expression of Cathepsin D in trophoblastic cells may be controlled by modes of regulation other than sex hormones.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.subjectCathepsin Den_HK
dc.subjectHormone receptorsen_HK
dc.subjectHydatidiform moleen_HK
dc.subject.meshCathepsin D - Chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydatidiform Mole - Metabolism - Pathologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshPregnancyen_US
dc.subject.meshReceptors, Estrogen - Chemistryen_US
dc.subject.meshReceptors, Progesterone - Chemistryen_US
dc.titleThe expression of cathepsin D, oestrogen receptor and progestogen receptor in hydatidiform mole - An immunohistochemical studyen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8847064-
dc.identifier.scopuseid_2-s2.0-0028886337en_HK
dc.identifier.hkuros9753en_US
dc.identifier.volume27en_HK
dc.identifier.issue4en_HK
dc.identifier.spage341en_HK
dc.identifier.epage347en_HK
dc.identifier.isiWOS:A1995RZ21500005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridNg, WF=25940213100en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK

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