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Article: Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

TitleExome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
Authors
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2011, v. 43 n. 12, p. 1219-1223 How to Cite?
AbstractGastric cancer is a heterogeneous disease with multiple environmental etiologies and alternative pathways of carcinogenesis. Beyond mutations in TP53, alterations in other genes or pathways account for only small subsets of the disease. We performed exome sequencing of 22 gastric cancer samples and identified previously unreported mutated genes and pathway alterations; in particular, we found genes involved in chromatin modification to be commonly mutated. A downstream validation study confirmed frequent inactivating mutations or protein deficiency of ARID1A, which encodes a member of the SWI-SNF chromatin remodeling family, in 83% of gastric cancers with microsatellite instability (MSI), 73% of those with Epstein-Barr virus (EBV) infection and 11% of those that were not infected with EBV and microsatellite stable (MSS). The mutation spectrum for ARID1A differs between molecular subtypes of gastric cancer, and mutation prevalence is negatively associated with mutations in TP53. Clinically, ARID1A alterations were associated with better prognosis in a stage-independent manner. These results reveal the genomic landscape, and highlight the importance of chromatin remodeling, in the molecular taxonomy of gastric cancer. © 2011 Nature America, Inc. All rights reserved.
DescriptionLetters
Persistent Identifierhttp://hdl.handle.net/10722/144577
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Ken_HK
dc.contributor.authorKan, Jen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorShi, STen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorChan, TLen_HK
dc.contributor.authorKan, Zen_HK
dc.contributor.authorChan, ASYen_HK
dc.contributor.authorTsui, WYen_HK
dc.contributor.authorLee, SPen_HK
dc.contributor.authorHo, SLen_HK
dc.contributor.authorChan, AKWen_HK
dc.contributor.authorCheng, GHWen_HK
dc.contributor.authorRoberts, PCen_HK
dc.contributor.authorRejto, PAen_HK
dc.contributor.authorGibson, NWen_HK
dc.contributor.authorPocalyko, DJen_HK
dc.contributor.authorMao, Men_HK
dc.contributor.authorXu, Jen_HK
dc.contributor.authorLeung, SYen_HK
dc.date.accessioned2012-02-03T06:14:58Z-
dc.date.available2012-02-03T06:14:58Z-
dc.date.issued2011en_HK
dc.identifier.citationNature Genetics, 2011, v. 43 n. 12, p. 1219-1223en_HK
dc.identifier.issn1061-4036en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144577-
dc.descriptionLetters-
dc.description.abstractGastric cancer is a heterogeneous disease with multiple environmental etiologies and alternative pathways of carcinogenesis. Beyond mutations in TP53, alterations in other genes or pathways account for only small subsets of the disease. We performed exome sequencing of 22 gastric cancer samples and identified previously unreported mutated genes and pathway alterations; in particular, we found genes involved in chromatin modification to be commonly mutated. A downstream validation study confirmed frequent inactivating mutations or protein deficiency of ARID1A, which encodes a member of the SWI-SNF chromatin remodeling family, in 83% of gastric cancers with microsatellite instability (MSI), 73% of those with Epstein-Barr virus (EBV) infection and 11% of those that were not infected with EBV and microsatellite stable (MSS). The mutation spectrum for ARID1A differs between molecular subtypes of gastric cancer, and mutation prevalence is negatively associated with mutations in TP53. Clinically, ARID1A alterations were associated with better prognosis in a stage-independent manner. These results reveal the genomic landscape, and highlight the importance of chromatin remodeling, in the molecular taxonomy of gastric cancer. © 2011 Nature America, Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_HK
dc.relation.ispartofNature Geneticsen_HK
dc.subject.meshExome-
dc.subject.meshMutation-
dc.subject.meshNuclear Proteins - genetics-
dc.subject.meshStomach Neoplasms - diagnosis - genetics - mortality-
dc.subject.meshTranscription Factors - genetics-
dc.titleExome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric canceren_HK
dc.typeArticleen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailChan, TL: tlchan@hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hkucc.hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityChan, TL=rp00418en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ng.982en_HK
dc.identifier.pmid22037554-
dc.identifier.scopuseid_2-s2.0-82255183148en_HK
dc.identifier.hkuros198161en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-82255183148&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1219en_HK
dc.identifier.epage1223en_HK
dc.identifier.eissn1546-1718-
dc.identifier.isiWOS:000297931400015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f100013382956-
dc.identifier.scopusauthoridWang, K=35286098800en_HK
dc.identifier.scopusauthoridKan, J=25825104800en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridShi, ST=7402200750en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridChan, TL=7402687537en_HK
dc.identifier.scopusauthoridKan, Z=7005868391en_HK
dc.identifier.scopusauthoridChan, ASY=7403168075en_HK
dc.identifier.scopusauthoridTsui, WY=7005623159en_HK
dc.identifier.scopusauthoridLee, SP=54781538000en_HK
dc.identifier.scopusauthoridHo, SL=37124072900en_HK
dc.identifier.scopusauthoridChan, AKW=37019606100en_HK
dc.identifier.scopusauthoridCheng, GHW=54781118800en_HK
dc.identifier.scopusauthoridRoberts, PC=54781822800en_HK
dc.identifier.scopusauthoridRejto, PA=6701572946en_HK
dc.identifier.scopusauthoridGibson, NW=55108823500en_HK
dc.identifier.scopusauthoridPocalyko, DJ=6506737621en_HK
dc.identifier.scopusauthoridMao, M=7102960472en_HK
dc.identifier.scopusauthoridXu, J=54409688500en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.citeulike9983118-

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