Article: ELF1 is associated with systemic lupus erythematosus in Asian populations

TitleELF1 is associated with systemic lupus erythematosus in Asian populations
Authors
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2011, v. 20 n. 3, p. 601-607 How to Cite?
AbstractSystemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic involvement. The susceptibility genes identified so far can only explain a small proportion of disease heritability. Through a genome-wide association in a Hong Kong Chinese cohort and subsequent replication in two other Asian populations, with a total of 3164 patients and 4482 matched controls, we identified association of ELF1 (E74-like factor 1) with SLE (rs7329174, OR = 1.26, joint P = 1.47 × 10 -8). ELF1 belongs to the ETS family of transcription factors and is known to be involved in T cell development and function. Database analysis revealed transcripts making use of three alternative exon1s for this gene. Near equivalent expression levels of distinct transcripts initiated from alternative exon1s were detected in peripheral blood mononuclear cells from both SLE patients and healthy controls. Although a direct association of rs7329174 with the three forms of transcripts for this gene was not detected, these findings support an important role of ELF1 in SLE susceptibility and suggest a potentially tight regulation for the expression of this gene. © The Author 2010. Published by Oxford University Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/142542
ISSN
2014 Impact Factor: 6.393
2014 SCImago Journal Rankings: 3.760
ISI Accession Number ID
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Research Grant Council of the Hong Kong Government (GRF)HKU781709M
National Natural Science Foundation of China30830089
National Research Council of Thailand
Thailand Research Fund
Research Grants Council of Hong Kong GRFHKU 7623/08M
HKU 7747/07M
HKU775608M
Edward Sai-Kim Hotung Paediatric Education and Research Fund
University Postgraduate Studentship
Funding Information:

This study was partially supported by the generous donation from Shun Tak District Min Yuen Tong of Hong Kong (to Y.L.L.). W.Y. thanks support from Research Grant Council of the Hong Kong Government (GRF HKU781709M). D.Q.Y. thanks grant support from the key program of National Natural Science Foundation of China (30830089). N.H. and Y.A. thank support from the National Research Council of Thailand; K.S. and V.S. thank supports from Thailand Research Fund. Genotyping of samples serving as controls in this study was supported by Research Grants Council of Hong Kong GRF (HKU 7623/08M, HKU 7747/07M and HKU775608M). Y.Z., S.Z. and J.Z. are supported by Edward Sai-Kim Hotung Paediatric Education and Research Fund and University Postgraduate Studentship.

References

 

DC FieldValueLanguage
dc.contributor.authorYang, Jen_HK
dc.contributor.authorYang, Wen_HK
dc.contributor.authorHirankarn, Nen_HK
dc.contributor.authorYe, DQen_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorPan, HFen_HK
dc.contributor.authorMok, CCen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorSing Wong, RWen_HK
dc.contributor.authorMok, MYen_HK
dc.contributor.authorLee, KWen_HK
dc.contributor.authorWong, SNen_HK
dc.contributor.authorHo Leung, AMen_HK
dc.contributor.authorLi, XPen_HK
dc.contributor.authorAvihingsanon, Yen_HK
dc.contributor.authorRianthavorn, Pen_HK
dc.contributor.authorDeekajorndej, Ten_HK
dc.contributor.authorSuphapeetiporn, Ken_HK
dc.contributor.authorShotelersuk, Ven_HK
dc.contributor.authorBaum, Len_HK
dc.contributor.authorKwan, Pen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorKung Ho, MHen_HK
dc.contributor.authorWah Lee, PPen_HK
dc.contributor.authorSang Wong, WHen_HK
dc.contributor.authorZeng, Sen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorWong, CMen_HK
dc.contributor.authorLin Ng, IOen_HK
dc.contributor.authorGarciaBarceló, MMen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2011-10-28T02:50:55Z-
dc.date.available2011-10-28T02:50:55Z-
dc.date.issued2011en_HK
dc.identifier.citationHuman Molecular Genetics, 2011, v. 20 n. 3, p. 601-607en_HK
dc.identifier.issn0964-6906en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142542-
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic involvement. The susceptibility genes identified so far can only explain a small proportion of disease heritability. Through a genome-wide association in a Hong Kong Chinese cohort and subsequent replication in two other Asian populations, with a total of 3164 patients and 4482 matched controls, we identified association of ELF1 (E74-like factor 1) with SLE (rs7329174, OR = 1.26, joint P = 1.47 × 10 -8). ELF1 belongs to the ETS family of transcription factors and is known to be involved in T cell development and function. Database analysis revealed transcripts making use of three alternative exon1s for this gene. Near equivalent expression levels of distinct transcripts initiated from alternative exon1s were detected in peripheral blood mononuclear cells from both SLE patients and healthy controls. Although a direct association of rs7329174 with the three forms of transcripts for this gene was not detected, these findings support an important role of ELF1 in SLE susceptibility and suggest a potentially tight regulation for the expression of this gene. © The Author 2010. Published by Oxford University Press. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Molecular Geneticsen_HK
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshEphrin-A2 - genetics-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenome-Wide Association Study-
dc.subject.meshLupus Erythematosus, Systemic - genetics-
dc.titleELF1 is associated with systemic lupus erythematosus in Asian populationsen_HK
dc.typeArticleen_HK
dc.identifier.emailYang, W: yangwl@hkucc.hku.hken_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailMok, MY: temy@hkucc.hku.hken_HK
dc.identifier.emailWah Lee, PP: ppwlee@hku.hken_HK
dc.identifier.emailWong, CM: jcmwong@hkucc.hku.hken_HK
dc.identifier.emailLin Ng, IO: iolng@hku.hken_HK
dc.identifier.emailGarciaBarceló, MM: mmgarcia@hku.hken_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLau, CS: cslau@hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityYang, W=rp00524en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityWah Lee, PP=rp00462en_HK
dc.identifier.authorityWong, CM=rp00231en_HK
dc.identifier.authorityLin Ng, IO=rp00335en_HK
dc.identifier.authorityGarciaBarceló, MM=rp00445en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/hmg/ddq474en_HK
dc.identifier.pmid21044949en_HK
dc.identifier.scopuseid_2-s2.0-78651086505en_HK
dc.identifier.hkuros184644en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651086505&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue3en_HK
dc.identifier.spage601en_HK
dc.identifier.epage607en_HK
dc.identifier.isiWOS:000286006300016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYang, J=46062593600en_HK
dc.identifier.scopusauthoridYang, W=23101349500en_HK
dc.identifier.scopusauthoridHirankarn, N=12783320200en_HK
dc.identifier.scopusauthoridYe, DQ=24588340700en_HK
dc.identifier.scopusauthoridZhang, Y=35789432400en_HK
dc.identifier.scopusauthoridPan, HF=35234356200en_HK
dc.identifier.scopusauthoridMok, CC=34668219600en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridSing Wong, RW=36739960000en_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridLee, KW=35788977700en_HK
dc.identifier.scopusauthoridWong, SN=7404590305en_HK
dc.identifier.scopusauthoridHo Leung, AM=36739190400en_HK
dc.identifier.scopusauthoridLi, XP=35237897300en_HK
dc.identifier.scopusauthoridAvihingsanon, Y=6506712307en_HK
dc.identifier.scopusauthoridRianthavorn, P=34067842100en_HK
dc.identifier.scopusauthoridDeekajorndej, T=46061875400en_HK
dc.identifier.scopusauthoridSuphapeetiporn, K=16064929100en_HK
dc.identifier.scopusauthoridShotelersuk, V=7003738743en_HK
dc.identifier.scopusauthoridBaum, L=7103310839en_HK
dc.identifier.scopusauthoridKwan, P=7004369601en_HK
dc.identifier.scopusauthoridLee, TL=8508917400en_HK
dc.identifier.scopusauthoridKung Ho, MH=36739200600en_HK
dc.identifier.scopusauthoridWah Lee, PP=14048822200en_HK
dc.identifier.scopusauthoridSang Wong, WH=36739921500en_HK
dc.identifier.scopusauthoridZeng, S=46062687500en_HK
dc.identifier.scopusauthoridZhang, J=46062629500en_HK
dc.identifier.scopusauthoridWong, CM=16314668400en_HK
dc.identifier.scopusauthoridLin Ng, IO=7102753722en_HK
dc.identifier.scopusauthoridGarciaBarceló, MM=6701767303en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.citeulike9859251-

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