Supplementary

Article: ELF1 is associated with systemic lupus erythematosus in Asian populations
  • Basic View
  • Metadata View
  • XML View
TitleELF1 is associated with systemic lupus erythematosus in Asian populations
 
AuthorsYang, J1
Yang, W1
Hirankarn, N5
Ye, DQ3
Zhang, Y1
Pan, HF3
Mok, CC2
Chan, TM1
Sing Wong, RW1
Mok, MY1
Lee, KW6
Wong, SN2
Ho Leung, AM4
Li, XP7
Avihingsanon, Y5
Rianthavorn, P5
Deekajorndej, T5
Suphapeetiporn, K5
Shotelersuk, V5
Baum, L8
Kwan, P8
Lee, TL1
Kung Ho, MH1
Wah Lee, PP1
Sang Wong, WH1
Zeng, S1
Zhang, J1
Wong, CM1
Lin Ng, IO1
GarciaBarceló, MM1
Cherny, SS1
Tam, PKH1
Sham, PC1
Lau, CS1
Lau, YL1
 
Issue Date2011
 
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
 
CitationHuman Molecular Genetics, 2011, v. 20 n. 3, p. 601-607 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/ddq474
 
AbstractSystemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic involvement. The susceptibility genes identified so far can only explain a small proportion of disease heritability. Through a genome-wide association in a Hong Kong Chinese cohort and subsequent replication in two other Asian populations, with a total of 3164 patients and 4482 matched controls, we identified association of ELF1 (E74-like factor 1) with SLE (rs7329174, OR = 1.26, joint P = 1.47 × 10 -8). ELF1 belongs to the ETS family of transcription factors and is known to be involved in T cell development and function. Database analysis revealed transcripts making use of three alternative exon1s for this gene. Near equivalent expression levels of distinct transcripts initiated from alternative exon1s were detected in peripheral blood mononuclear cells from both SLE patients and healthy controls. Although a direct association of rs7329174 with the three forms of transcripts for this gene was not detected, these findings support an important role of ELF1 in SLE susceptibility and suggest a potentially tight regulation for the expression of this gene. © The Author 2010. Published by Oxford University Press. All rights reserved.
 
ISSN0964-6906
2013 Impact Factor: 6.677
 
DOIhttp://dx.doi.org/10.1093/hmg/ddq474
 
ISI Accession Number IDWOS:000286006300016
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Research Grant Council of the Hong Kong Government (GRF)HKU781709M
National Natural Science Foundation of China30830089
National Research Council of Thailand
Thailand Research Fund
Research Grants Council of Hong Kong GRFHKU 7623/08M
HKU 7747/07M
HKU775608M
Edward Sai-Kim Hotung Paediatric Education and Research Fund
University Postgraduate Studentship
Funding Information:

This study was partially supported by the generous donation from Shun Tak District Min Yuen Tong of Hong Kong (to Y.L.L.). W.Y. thanks support from Research Grant Council of the Hong Kong Government (GRF HKU781709M). D.Q.Y. thanks grant support from the key program of National Natural Science Foundation of China (30830089). N.H. and Y.A. thank support from the National Research Council of Thailand; K.S. and V.S. thank supports from Thailand Research Fund. Genotyping of samples serving as controls in this study was supported by Research Grants Council of Hong Kong GRF (HKU 7623/08M, HKU 7747/07M and HKU775608M). Y.Z., S.Z. and J.Z. are supported by Edward Sai-Kim Hotung Paediatric Education and Research Fund and University Postgraduate Studentship.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYang, J
 
dc.contributor.authorYang, W
 
dc.contributor.authorHirankarn, N
 
dc.contributor.authorYe, DQ
 
dc.contributor.authorZhang, Y
 
dc.contributor.authorPan, HF
 
dc.contributor.authorMok, CC
 
dc.contributor.authorChan, TM
 
dc.contributor.authorSing Wong, RW
 
dc.contributor.authorMok, MY
 
dc.contributor.authorLee, KW
 
dc.contributor.authorWong, SN
 
dc.contributor.authorHo Leung, AM
 
dc.contributor.authorLi, XP
 
dc.contributor.authorAvihingsanon, Y
 
dc.contributor.authorRianthavorn, P
 
dc.contributor.authorDeekajorndej, T
 
dc.contributor.authorSuphapeetiporn, K
 
dc.contributor.authorShotelersuk, V
 
dc.contributor.authorBaum, L
 
dc.contributor.authorKwan, P
 
dc.contributor.authorLee, TL
 
dc.contributor.authorKung Ho, MH
 
dc.contributor.authorWah Lee, PP
 
dc.contributor.authorSang Wong, WH
 
dc.contributor.authorZeng, S
 
dc.contributor.authorZhang, J
 
dc.contributor.authorWong, CM
 
dc.contributor.authorLin Ng, IO
 
dc.contributor.authorGarciaBarceló, MM
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorTam, PKH
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLau, CS
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2011-10-28T02:50:55Z
 
dc.date.available2011-10-28T02:50:55Z
 
dc.date.issued2011
 
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic involvement. The susceptibility genes identified so far can only explain a small proportion of disease heritability. Through a genome-wide association in a Hong Kong Chinese cohort and subsequent replication in two other Asian populations, with a total of 3164 patients and 4482 matched controls, we identified association of ELF1 (E74-like factor 1) with SLE (rs7329174, OR = 1.26, joint P = 1.47 × 10 -8). ELF1 belongs to the ETS family of transcription factors and is known to be involved in T cell development and function. Database analysis revealed transcripts making use of three alternative exon1s for this gene. Near equivalent expression levels of distinct transcripts initiated from alternative exon1s were detected in peripheral blood mononuclear cells from both SLE patients and healthy controls. Although a direct association of rs7329174 with the three forms of transcripts for this gene was not detected, these findings support an important role of ELF1 in SLE susceptibility and suggest a potentially tight regulation for the expression of this gene. © The Author 2010. Published by Oxford University Press. All rights reserved.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationHuman Molecular Genetics, 2011, v. 20 n. 3, p. 601-607 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/ddq474
 
dc.identifier.citeulike9859251
 
dc.identifier.doihttp://dx.doi.org/10.1093/hmg/ddq474
 
dc.identifier.epage607
 
dc.identifier.hkuros184644
 
dc.identifier.isiWOS:000286006300016
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Research Grant Council of the Hong Kong Government (GRF)HKU781709M
National Natural Science Foundation of China30830089
National Research Council of Thailand
Thailand Research Fund
Research Grants Council of Hong Kong GRFHKU 7623/08M
HKU 7747/07M
HKU775608M
Edward Sai-Kim Hotung Paediatric Education and Research Fund
University Postgraduate Studentship
Funding Information:

This study was partially supported by the generous donation from Shun Tak District Min Yuen Tong of Hong Kong (to Y.L.L.). W.Y. thanks support from Research Grant Council of the Hong Kong Government (GRF HKU781709M). D.Q.Y. thanks grant support from the key program of National Natural Science Foundation of China (30830089). N.H. and Y.A. thank support from the National Research Council of Thailand; K.S. and V.S. thank supports from Thailand Research Fund. Genotyping of samples serving as controls in this study was supported by Research Grants Council of Hong Kong GRF (HKU 7623/08M, HKU 7747/07M and HKU775608M). Y.Z., S.Z. and J.Z. are supported by Edward Sai-Kim Hotung Paediatric Education and Research Fund and University Postgraduate Studentship.

 
dc.identifier.issn0964-6906
2013 Impact Factor: 6.677
 
dc.identifier.issue3
 
dc.identifier.pmid21044949
 
dc.identifier.scopuseid_2-s2.0-78651086505
 
dc.identifier.spage601
 
dc.identifier.urihttp://hdl.handle.net/10722/142542
 
dc.identifier.volume20
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHuman Molecular Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshEphrin-A2 - genetics
 
dc.subject.meshGenetic Predisposition to Disease
 
dc.subject.meshGenome-Wide Association Study
 
dc.subject.meshLupus Erythematosus, Systemic - genetics
 
dc.titleELF1 is associated with systemic lupus erythematosus in Asian populations
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Yang, J</contributor.author>
<contributor.author>Yang, W</contributor.author>
<contributor.author>Hirankarn, N</contributor.author>
<contributor.author>Ye, DQ</contributor.author>
<contributor.author>Zhang, Y</contributor.author>
<contributor.author>Pan, HF</contributor.author>
<contributor.author>Mok, CC</contributor.author>
<contributor.author>Chan, TM</contributor.author>
<contributor.author>Sing Wong, RW</contributor.author>
<contributor.author>Mok, MY</contributor.author>
<contributor.author>Lee, KW</contributor.author>
<contributor.author>Wong, SN</contributor.author>
<contributor.author>Ho Leung, AM</contributor.author>
<contributor.author>Li, XP</contributor.author>
<contributor.author>Avihingsanon, Y</contributor.author>
<contributor.author>Rianthavorn, P</contributor.author>
<contributor.author>Deekajorndej, T</contributor.author>
<contributor.author>Suphapeetiporn, K</contributor.author>
<contributor.author>Shotelersuk, V</contributor.author>
<contributor.author>Baum, L</contributor.author>
<contributor.author>Kwan, P</contributor.author>
<contributor.author>Lee, TL</contributor.author>
<contributor.author>Kung Ho, MH</contributor.author>
<contributor.author>Wah Lee, PP</contributor.author>
<contributor.author>Sang Wong, WH</contributor.author>
<contributor.author>Zeng, S</contributor.author>
<contributor.author>Zhang, J</contributor.author>
<contributor.author>Wong, CM</contributor.author>
<contributor.author>Lin Ng, IO</contributor.author>
<contributor.author>GarciaBarcel&#243;, MM</contributor.author>
<contributor.author>Cherny, SS</contributor.author>
<contributor.author>Tam, PKH</contributor.author>
<contributor.author>Sham, PC</contributor.author>
<contributor.author>Lau, CS</contributor.author>
<contributor.author>Lau, YL</contributor.author>
<date.accessioned>2011-10-28T02:50:55Z</date.accessioned>
<date.available>2011-10-28T02:50:55Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Human Molecular Genetics, 2011, v. 20 n. 3, p. 601-607</identifier.citation>
<identifier.issn>0964-6906</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/142542</identifier.uri>
<description.abstract>Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic involvement. The susceptibility genes identified so far can only explain a small proportion of disease heritability. Through a genome-wide association in a Hong Kong Chinese cohort and subsequent replication in two other Asian populations, with a total of 3164 patients and 4482 matched controls, we identified association of ELF1 (E74-like factor 1) with SLE (rs7329174, OR = 1.26, joint P = 1.47 &#215; 10 -8). ELF1 belongs to the ETS family of transcription factors and is known to be involved in T cell development and function. Database analysis revealed transcripts making use of three alternative exon1s for this gene. Near equivalent expression levels of distinct transcripts initiated from alternative exon1s were detected in peripheral blood mononuclear cells from both SLE patients and healthy controls. Although a direct association of rs7329174 with the three forms of transcripts for this gene was not detected, these findings support an important role of ELF1 in SLE susceptibility and suggest a potentially tight regulation for the expression of this gene. &#169; The Author 2010. Published by Oxford University Press. All rights reserved.</description.abstract>
<language>eng</language>
<publisher>Oxford University Press. The Journal&apos;s web site is located at http://hmg.oxfordjournals.org/</publisher>
<relation.ispartof>Human Molecular Genetics</relation.ispartof>
<subject.mesh>Asian Continental Ancestry Group - genetics</subject.mesh>
<subject.mesh>Ephrin-A2 - genetics</subject.mesh>
<subject.mesh>Genetic Predisposition to Disease</subject.mesh>
<subject.mesh>Genome-Wide Association Study</subject.mesh>
<subject.mesh>Lupus Erythematosus, Systemic - genetics</subject.mesh>
<title>ELF1 is associated with systemic lupus erythematosus in Asian populations</title>
<type>Article</type>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.1093/hmg/ddq474</identifier.doi>
<identifier.pmid>21044949</identifier.pmid>
<identifier.scopus>eid_2-s2.0-78651086505</identifier.scopus>
<identifier.hkuros>184644</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-78651086505&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>20</identifier.volume>
<identifier.issue>3</identifier.issue>
<identifier.spage>601</identifier.spage>
<identifier.epage>607</identifier.epage>
<identifier.isi>WOS:000286006300016</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
<identifier.citeulike>9859251</identifier.citeulike>
<bitstream.url>http://hub.hku.hk/bitstream/10722/142542/1/re01.htm</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Tuen Mun Hospital
  3. Anhui Medical University
  4. Queen Elizabeth Hospital Hong Kong
  5. Chulalongkorn University
  6. Pamela Youde Nethersole Eastern Hospital
  7. Anhui Provincial Hospital
  8. Chinese University of Hong Kong