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Article: Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study

TitleGenetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study
Authors
Issue Date2011
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/
Citation
European Journal Of Endocrinology, 2011, v. 164 n. 3, p. 381-388 How to Cite?
AbstractObjective: Central obesity predisposes to various cardiometabolic diseases and is a key component of the metabolic syndrome (MetS). We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population. In this study, we investigate whether these SNPs could also predict the persistence of central obesity and MetS in subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS) cohort. Design and methods: We genotyped these SNPs in i) 354 subjects with and 994 subjects without central obesity at both baseline and a 12-year follow-up, ii) 2214 subjects (816 cases and 1398 controls) in an MetS cross-sectional case-control study and iii) 225 subjects with and 1221 subjects without MetS at both baseline and the 12-year follow-up. Results: Both FTO rs8050136 (P age, sex-adjusted=0.019; odds ratio (OR) (95% confidence intervals (CI)): 1.35 (1.05, 1.73)) and GNPDA2 rs10938397 (P age, sex-adjusted= 3×10 -3; OR (95% CI): 1.34 (1.11, 1.63)) were significantly associated with persistent central obesity. GNPDA2 rs10938397 was also significantly associated with MetS (P age, sex-adjusted=0.011, OR (95% CI): 1.20 (1.04, 1.38)) in the case-control study. However, none of these SNPs showed an individual association with persistent MetS. In the combined genetic risk analyses for persistent central obesity and persistent MetS, the combined genetic risk score of the three SNPs showed an OR of 1.25 (95% CI: 1.10, 1.42; P age, sex-adjusted=4.92×10 -3) and 1.19 (95% CI: 1.03, 1.38; P age, sex-adjusted=0.019) for each additional risk allele respectively. Conclusion: This study demonstrated that FTO and GNPDA2 variants predicted persistent central obesity in the Chinese population, further supporting their importance as obesity-susceptible genes. © 2011 European Society of Endocrinology.
Persistent Identifierhttp://hdl.handle.net/10722/142382
ISSN
2015 Impact Factor: 3.892
2015 SCImago Journal Rankings: 1.579
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilGRF7802/10
University of Hong Kong
Funding Information:

This work was supported by a grant from the Hong Kong Research Grant Council (GRF7802/10).

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CYYen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorLaw, LSCen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2011-10-28T02:44:44Z-
dc.date.available2011-10-28T02:44:44Z-
dc.date.issued2011en_HK
dc.identifier.citationEuropean Journal Of Endocrinology, 2011, v. 164 n. 3, p. 381-388en_HK
dc.identifier.issn0804-4643en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142382-
dc.description.abstractObjective: Central obesity predisposes to various cardiometabolic diseases and is a key component of the metabolic syndrome (MetS). We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population. In this study, we investigate whether these SNPs could also predict the persistence of central obesity and MetS in subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS) cohort. Design and methods: We genotyped these SNPs in i) 354 subjects with and 994 subjects without central obesity at both baseline and a 12-year follow-up, ii) 2214 subjects (816 cases and 1398 controls) in an MetS cross-sectional case-control study and iii) 225 subjects with and 1221 subjects without MetS at both baseline and the 12-year follow-up. Results: Both FTO rs8050136 (P age, sex-adjusted=0.019; odds ratio (OR) (95% confidence intervals (CI)): 1.35 (1.05, 1.73)) and GNPDA2 rs10938397 (P age, sex-adjusted= 3×10 -3; OR (95% CI): 1.34 (1.11, 1.63)) were significantly associated with persistent central obesity. GNPDA2 rs10938397 was also significantly associated with MetS (P age, sex-adjusted=0.011, OR (95% CI): 1.20 (1.04, 1.38)) in the case-control study. However, none of these SNPs showed an individual association with persistent MetS. In the combined genetic risk analyses for persistent central obesity and persistent MetS, the combined genetic risk score of the three SNPs showed an OR of 1.25 (95% CI: 1.10, 1.42; P age, sex-adjusted=4.92×10 -3) and 1.19 (95% CI: 1.03, 1.38; P age, sex-adjusted=0.019) for each additional risk allele respectively. Conclusion: This study demonstrated that FTO and GNPDA2 variants predicted persistent central obesity in the Chinese population, further supporting their importance as obesity-susceptible genes. © 2011 European Society of Endocrinology.en_HK
dc.languageengen_US
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/en_HK
dc.relation.ispartofEuropean Journal of Endocrinologyen_HK
dc.subject.meshGenetic Variation-
dc.subject.meshGenotype-
dc.subject.meshMetabolic Syndrome X - genetics-
dc.subject.meshObesity - genetics-
dc.subject.meshPolymorphism, Single Nucleotide - genetics-
dc.titleGenetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal studyen_HK
dc.typeArticleen_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1530/EJE-10-0902en_HK
dc.identifier.pmid21147891-
dc.identifier.scopuseid_2-s2.0-79951982032en_HK
dc.identifier.hkuros184653en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951982032&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume164en_HK
dc.identifier.issue3en_HK
dc.identifier.spage381en_HK
dc.identifier.epage388en_HK
dc.identifier.isiWOS:000287969100009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, CYY=36022243200en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridLaw, LSC=36994511000en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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