Granted Patent: Biofunctional Magnetic Nanoparticles For Pathogen Detection
| Title | Biofunctional Magnetic Nanoparticles For Pathogen Detection |
|---|---|
| Granted Patent | US 7754444 |
| Granted Date | 2010-07-13 |
| Priority Date | 2005-06-23 US 11/159882 2004-06-24 US 11/582700P |
| Inventors | Ho, Pak Leung Ho, Pak Leung Gu, Hongwei |
| Citation | US Patent 7754444. Washington, DC: US Patent and Trademark Office (USPTO), 2010 [How to Cite?] |
| Abstract | This Invention Provides A Method Of Detecting Pathogens Comprising The Steps Of: (A) Contacting A Sufficient Amount Of Biofunctional Magnetic Nanoparticles With An Appropriate Sample For An Appropriate Period Of Time To Permit The Formation Of Complexes Between The Pathogens In The Sample And The Nanoparticles; (B) Using A Magnetic Field To Aggregate Said Complexes; And (C) Detecting Said Complexes. The Method May Further Comprise The Additional Step Of Removing Said Complexes. The Biofunctional Magnetic Nanoparticles Are Preferably A Conjugate Of Vancomycin And Fept. The Pathogens May Be Bacteria Or Viruses, And The Sample May Be A Solid, Liquid, Or Gas. Detection May Involve Conventional Fluorescence Assay, Enzyme-Linked Immunosorbent Assay (Elisa), Optical Microscope, Electron Microscope, Or A Combination Thereof.; The Sensitivity Of Detection For The Method Is At Least As Low As 10 Colony Forming Units (Cfu) Of The Pathogens In One Milliliter Of Solution Within One Hour. |
| References | US 4590922 (A) 1986-05-27 US 5279936 (A) 1994-01-18 US 2004247924 (A1) 2004-12-09 US 7186398 (B2) 2007-03-06 US 2004058389 (A1) 2004-03-25 US 7176036 (B2) 2007-02-13 US 2006188876 (A1) 2006-08-24 US 6254662 (B1) 2001-07-03 US 6262129 (B1) 2001-07-17 US 2001009119 (A1) 2001-07-26 US 6302940 (B2) 2001-10-16 US 6620627 (B1) 2003-09-16 DE 10027607 (A1) 2001-12-20 DE 10027607 (C2) 2003-04-03 WO 0110558 (A1) 2001-02-15 WO 0220825 (A1) 2002-03-14 WO 02090565 (A2) 2002-11-14 WO 02090565 (A3) 2004-03-04 |
| dc.contributor.inventor | Ho, Pak Leung |
|---|---|
| dc.contributor.inventor | Ho, Pak Leung |
| dc.contributor.inventor | Gu, Hongwei |
| dc.date.accessioned | 2011-10-19T06:32:47Z |
| patents.date.application | 2005-06-23 |
| dc.date.available | 2011-10-19T06:32:47Z |
| patents.date.granted | 2010-07-13 |
| patents.date.priority | 2005-06-23 US 11/159882 |
| patents.date.priority | 2004-06-24 US 11/582700P |
| patents.date.publication | 2006-12-28 |
| dc.description.abstract | This Invention Provides A Method Of Detecting Pathogens Comprising The Steps Of: (A) Contacting A Sufficient Amount Of Biofunctional Magnetic Nanoparticles With An Appropriate Sample For An Appropriate Period Of Time To Permit The Formation Of Complexes Between The Pathogens In The Sample And The Nanoparticles; (B) Using A Magnetic Field To Aggregate Said Complexes; And (C) Detecting Said Complexes. The Method May Further Comprise The Additional Step Of Removing Said Complexes. The Biofunctional Magnetic Nanoparticles Are Preferably A Conjugate Of Vancomycin And Fept. The Pathogens May Be Bacteria Or Viruses, And The Sample May Be A Solid, Liquid, Or Gas. Detection May Involve Conventional Fluorescence Assay, Enzyme-Linked Immunosorbent Assay (Elisa), Optical Microscope, Electron Microscope, Or A Combination Thereof.; The Sensitivity Of Detection For The Method Is At Least As Low As 10 Colony Forming Units (Cfu) Of The Pathogens In One Milliliter Of Solution Within One Hour. |
| patents.description.assignee | Univ Hong Kong Science & Techn [Cn] |
| patents.description.cc | US |
| patents.description.country | United States of America |
| patents.description.kind | B2 |
| dc.description.nature | published_or_final_version |
| patents.identifier.application | US 11/159882 |
| dc.identifier.citation | US Patent 7754444. Washington, DC: US Patent and Trademark Office (USPTO), 2010 [How to Cite?] |
| patents.identifier.granted | US 7754444 |
| dc.identifier.hkuros | 106032 |
| patents.identifier.hkutechid | Micro-2004-00177 |
| patents.identifier.publication | US 20060292555 |
| dc.identifier.uri | http://hdl.handle.net/10722/142156 |
| patents.relation.family | US 2006292555 (A1) 2006-12-28 |
| patents.relation.family | US 7754444 (B2) 2010-07-13 |
| dc.relation.isreferencedby | WO 2010034846 (A1) 2010-04-01 |
| dc.relation.references | US 4590922 (A) 1986-05-27 |
| dc.relation.references | US 5279936 (A) 1994-01-18 |
| dc.relation.references | US 2004247924 (A1) 2004-12-09 |
| dc.relation.references | US 7186398 (B2) 2007-03-06 |
| dc.relation.references | US 2004058389 (A1) 2004-03-25 |
| dc.relation.references | US 7176036 (B2) 2007-02-13 |
| dc.relation.references | US 2006188876 (A1) 2006-08-24 |
| dc.relation.references | US 6254662 (B1) 2001-07-03 |
| dc.relation.references | US 6262129 (B1) 2001-07-17 |
| dc.relation.references | US 2001009119 (A1) 2001-07-26 |
| dc.relation.references | US 6302940 (B2) 2001-10-16 |
| dc.relation.references | US 6620627 (B1) 2003-09-16 |
| dc.relation.references | DE 10027607 (A1) 2001-12-20 |
| dc.relation.references | DE 10027607 (C2) 2003-04-03 |
| dc.relation.references | WO 0110558 (A1) 2001-02-15 |
| dc.relation.references | WO 0220825 (A1) 2002-03-14 |
| dc.relation.references | WO 02090565 (A2) 2002-11-14 |
| dc.relation.references | WO 02090565 (A3) 2004-03-04 |
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents |
| dc.title | Biofunctional Magnetic Nanoparticles For Pathogen Detection |
| dc.type | Patent |
| patents.type | Patent_granted |