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Article: Prevalence and risk factors of human papillomavirus (hpv) infection in southern chinese women - a population-based study

TitlePrevalence and risk factors of human papillomavirus (hpv) infection in southern chinese women - a population-based study
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 5 How to Cite?
AbstractBackground: Persistent high-risk type Human papillomavirus (HPV) infection is recognized as a necessary cause of cervical cancer. This study aimed to compare the HPV prevalence and risk factors between women residing in Hong Kong (HK) and Guangzhou (GZ) region of China. Methodology/Principal Findings: A total of 1,570 and 1,369 women were recruited from HK and GZ, respectively. The cytology samples were collected and tested for HPV infection. The overall and type-specific HPV prevalence and the potential risk factors for acquisition of HPV infection were studied. Women with normal cytology in the GZ cohort had significantly higher HPV prevalence (10%) than those in the HK cohort (6.2%, p<0.001). The patterns of the age-specific HPV prevalence were also different between the two cohorts. In the HK cohort, women at the age of 20-29 years old had the highest prevalence and a second peak was observed in the age of ≥60 years old. In the GZ cohort, the highest HPV prevalence was also observed in 20-29 years old but declined as the age increased and a second peak was not seen. HPV16 and HPV52 were the most common high-risk types found in the HK and GZ cohorts, respectively. Age was the most consistently observed independent risk factor for HPV infection in the HK, while the number of sexual partners had association in the GZ cohort. Conclusions/Significance: Our study provides the current status and the epidemiological characteristics of HPV prevalence in Southern Chinese women. The results strongly suggested that population education and the effective cervical cancer screening would be vital in the prevention of cervical cancer. © 2011 Liu et al.
Persistent Identifierhttp://hdl.handle.net/10722/135951
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Special Administrative Region GovernmentRFCID: 05050052
Funding Information:

This study was supported by a grant from Research Fund for the Control of Infectious Disease Grant, Hong Kong Special Administrative Region Government (RFCID: 05050052). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, SSen_HK
dc.contributor.authorChan, KYKen_HK
dc.contributor.authorLeung, RCYen_HK
dc.contributor.authorChan, KKLen_HK
dc.contributor.authorTam, KFen_HK
dc.contributor.authorLuk, MHMen_HK
dc.contributor.authorLo, SSTen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorLin, ZQen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2011-07-27T02:00:27Z-
dc.date.available2011-07-27T02:00:27Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 5en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135951-
dc.description.abstractBackground: Persistent high-risk type Human papillomavirus (HPV) infection is recognized as a necessary cause of cervical cancer. This study aimed to compare the HPV prevalence and risk factors between women residing in Hong Kong (HK) and Guangzhou (GZ) region of China. Methodology/Principal Findings: A total of 1,570 and 1,369 women were recruited from HK and GZ, respectively. The cytology samples were collected and tested for HPV infection. The overall and type-specific HPV prevalence and the potential risk factors for acquisition of HPV infection were studied. Women with normal cytology in the GZ cohort had significantly higher HPV prevalence (10%) than those in the HK cohort (6.2%, p<0.001). The patterns of the age-specific HPV prevalence were also different between the two cohorts. In the HK cohort, women at the age of 20-29 years old had the highest prevalence and a second peak was observed in the age of ≥60 years old. In the GZ cohort, the highest HPV prevalence was also observed in 20-29 years old but declined as the age increased and a second peak was not seen. HPV16 and HPV52 were the most common high-risk types found in the HK and GZ cohorts, respectively. Age was the most consistently observed independent risk factor for HPV infection in the HK, while the number of sexual partners had association in the GZ cohort. Conclusions/Significance: Our study provides the current status and the epidemiological characteristics of HPV prevalence in Southern Chinese women. The results strongly suggested that population education and the effective cervical cancer screening would be vital in the prevention of cervical cancer. © 2011 Liu et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAsian Continental Ancestry Group-
dc.subject.meshCervix Uteri - virology-
dc.subject.meshCohort Studies-
dc.subject.meshDNA, Viral - genetics-
dc.subject.meshPapillomavirus Infections - epidemiology - ethnology - virology-
dc.titlePrevalence and risk factors of human papillomavirus (hpv) infection in southern chinese women - a population-based studyen_HK
dc.typeArticleen_HK
dc.identifier.emailLiu, SS: stephasl@hku.hken_HK
dc.identifier.emailChan, KKL: kklchan@hkucc.hku.hken_HK
dc.identifier.emailLuk, MHM: mayhmluk@hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, SS=rp00372en_HK
dc.identifier.authorityChan, KKL=rp00499en_HK
dc.identifier.authorityLuk, MHM=rp01702en_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0019244en_HK
dc.identifier.pmid21559276-
dc.identifier.pmcidPMC3086888-
dc.identifier.scopuseid_2-s2.0-79955776447en_HK
dc.identifier.hkuros187464en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955776447&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue5en_HK
dc.identifier.spagee19244en_US
dc.identifier.epagee19244-
dc.identifier.isiWOS:000290223500013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, SS=37102450400en_HK
dc.identifier.scopusauthoridChan, KYK=36989360800en_HK
dc.identifier.scopusauthoridLeung, RCY=7101876103en_HK
dc.identifier.scopusauthoridChan, KKL=8655666700en_HK
dc.identifier.scopusauthoridTam, KF=7201692816en_HK
dc.identifier.scopusauthoridLuk, MHM=52163799100en_HK
dc.identifier.scopusauthoridLo, SST=8718876900en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridLin, ZQ=13406858100en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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