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Article: Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition

TitleSystemic sclerosis is an independent risk factor for increased coronary artery calcium deposition
Authors
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
Citation
Arthritis And Rheumatism, 2011, v. 63 n. 5, p. 1387-1395 How to Cite?
AbstractObjective: Endothelial dysfunction and inflammation are pathogenic mechanisms common to systemic sclerosis (SSc) and atherosclerosis. This study was undertaken to examine the relationship between coronary atherosclerosis, as assessed by the coronary artery calcium score (CACS), and conventional cardiovascular and disease-specific risk factors in SSc patients. Methods: The CACS was measured by computed tomography, and cardiovascular risk factors were examined in SSc patients and compared with controls matched for age, sex, and glycemic status. Disease activity score, antiphospholipid antibodies, high-sensitivity C-reactive protein level, and erythrocyte sedimentation rate were measured in SSc patients. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined. Results: We recruited 53 SSc patients (50 women and 3 men) and 106 controls. The patients had a mean ± SD age of 53.1 ± 12.9 years and a median disease duration of 9 years. Compared to controls, SSc patients had significantly lower low-density lipoprotein (LDL) cholesterol levels (P = 0.001), high-density lipoprotein cholesterol levels (P = 0.01), diastolic blood pressure, waist circumference, and body mass index and were more likely to be receiving vasodilators (all P < 0.001). There was a significantly higher proportion of SSc patients among subjects with more severe coronary calcification (CACS 101) compared to those with lesser severity (CACS <100) (56.5% versus 29.4%; P = 0.01). Multiple logistic regression analysis revealed SSc to be an independent determinant for a CACS 101 (OR 10.89 [95% CI 2.21-53.75], P = 0.003) together with age and LDL cholesterol level after adjustment for other cardiovascular risk factors. Among disease-specific factors, only disease duration (OR 1.14 [95% CI 1.02-1.27], P = 0.02) was independently associated with more severe coronary calcification (CACS 101). Conclusion: Our findings indicate that SSc is an independent risk factor for coronary calcification, in addition to the conventional risk factors for coronary atherosclerosis, such as age and hypertension. Copyright © 2011 by the American College of Rheumatology.
Persistent Identifierhttp://hdl.handle.net/10722/135202
ISSN
2014 Impact Factor: 7.764
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Arthritis and Rheumatism Foundation
Merck Sharpe Dohme
Roche
Pfizer
Novartis
Johnson Johnson
Funding Information:

Supported by the Hong Kong Arthritis and Rheumatism Foundation Research Fund.

References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorChiu, SSHen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorLo, Yen_HK
dc.contributor.authorLaw, LSCen_HK
dc.contributor.authorMak, KFen_HK
dc.contributor.authorWong, WSen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2011-07-27T01:29:56Z-
dc.date.available2011-07-27T01:29:56Z-
dc.date.issued2011en_HK
dc.identifier.citationArthritis And Rheumatism, 2011, v. 63 n. 5, p. 1387-1395en_HK
dc.identifier.issn0004-3591en_HK
dc.identifier.urihttp://hdl.handle.net/10722/135202-
dc.description.abstractObjective: Endothelial dysfunction and inflammation are pathogenic mechanisms common to systemic sclerosis (SSc) and atherosclerosis. This study was undertaken to examine the relationship between coronary atherosclerosis, as assessed by the coronary artery calcium score (CACS), and conventional cardiovascular and disease-specific risk factors in SSc patients. Methods: The CACS was measured by computed tomography, and cardiovascular risk factors were examined in SSc patients and compared with controls matched for age, sex, and glycemic status. Disease activity score, antiphospholipid antibodies, high-sensitivity C-reactive protein level, and erythrocyte sedimentation rate were measured in SSc patients. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined. Results: We recruited 53 SSc patients (50 women and 3 men) and 106 controls. The patients had a mean ± SD age of 53.1 ± 12.9 years and a median disease duration of 9 years. Compared to controls, SSc patients had significantly lower low-density lipoprotein (LDL) cholesterol levels (P = 0.001), high-density lipoprotein cholesterol levels (P = 0.01), diastolic blood pressure, waist circumference, and body mass index and were more likely to be receiving vasodilators (all P < 0.001). There was a significantly higher proportion of SSc patients among subjects with more severe coronary calcification (CACS 101) compared to those with lesser severity (CACS <100) (56.5% versus 29.4%; P = 0.01). Multiple logistic regression analysis revealed SSc to be an independent determinant for a CACS 101 (OR 10.89 [95% CI 2.21-53.75], P = 0.003) together with age and LDL cholesterol level after adjustment for other cardiovascular risk factors. Among disease-specific factors, only disease duration (OR 1.14 [95% CI 1.02-1.27], P = 0.02) was independently associated with more severe coronary calcification (CACS 101). Conclusion: Our findings indicate that SSc is an independent risk factor for coronary calcification, in addition to the conventional risk factors for coronary atherosclerosis, such as age and hypertension. Copyright © 2011 by the American College of Rheumatology.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/en_HK
dc.relation.ispartofArthritis and Rheumatismen_HK
dc.rightsArthritis & Rheumatism. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshCalcinosis - etiology - radiography-
dc.subject.meshCarotid Artery, Common - radiography-
dc.subject.meshCoronary Artery Disease - etiology - radiography-
dc.subject.meshLogistic Models-
dc.subject.meshScleroderma, Systemic - complications - radiography-
dc.titleSystemic sclerosis is an independent risk factor for increased coronary artery calcium depositionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0004-3591&volume=63&issue=5&spage=1387&epage=1395&date=2011&atitle=Systemic+sclerosis+is+an+independent+risk+factor+for+increased+coronary+artery+calcium+deposition-
dc.identifier.emailMok, MY: temy@hkucc.hku.hken_HK
dc.identifier.emailLau, CS: cslau@hku.hken_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailMak, KF: makkf@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityMak, KF=rp00533en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/art.30283en_HK
dc.identifier.pmid21538320en_HK
dc.identifier.scopuseid_2-s2.0-79955555100en_HK
dc.identifier.hkuros186534en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955555100&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1387en_HK
dc.identifier.epage1395en_HK
dc.identifier.isiWOS:000290609800028-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridChiu, SSH=34973870500en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridLo, Y=35148230000en_HK
dc.identifier.scopusauthoridLaw, LSC=36994511000en_HK
dc.identifier.scopusauthoridMak, KF=7004699149en_HK
dc.identifier.scopusauthoridWong, WS=8737892100en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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