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Article: Quantitative assessment of the cervical spinal cord damage in neuromyelitis optica using diffusion tensor imaging at 3 Tesla

TitleQuantitative assessment of the cervical spinal cord damage in neuromyelitis optica using diffusion tensor imaging at 3 Tesla
Authors
Keywordscervical spinal cord
diffusion tensor imaging
neuromyelitis optica
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal Of Magnetic Resonance Imaging, 2011, v. 33 n. 6, p. 1312-1320 How to Cite?
AbstractPurpose: To investigate whether quantitative MRI measures of cervical spinal cord white matter (WM) using diffusion tensor imaging (DTI) in neuromyelitis optica (NMO) differed from controls and correlated with clinical disability. Materials and Methods: Ten referred patients and 12 healthy volunteers were imaged on a 3 Tesla scanner and patients were clinically assessed on the Expanded Disability Status Scale (EDSS). Two raters quantified DTI-derived indices from all participants, including fractional anisotropy (FA), mean diffusivity (MD), parallel diffusivity (lambda[parallel]) and perpendicular diffusivity (lambda[perpendicular]) at C1-C6 for lateral and dorsal columns. After the inter-rater reliability test, univariate correlations between DTI measures and disability were assessed using the Spearman's rho correlation coefficient. Multiple regression analysis was performed to investigate which DTI measures independently correlated with the clinical score. Results: Statistical test results indicated high reliability of all DTI measurements between two raters. NMO patients showed reduced FA, increased MD and lambda[perpendicular] compared with controls while lambda[parallel] did not show any significant difference. The former three DTI metrics also showed significant correlations with disability scores, and especially FA was found to be sensitive to mild NMO (EDSS ≤ 3) Conclusion: FA is a potentially useful quantitative biomarker of otherwise normal appearing WM damage in NMO. Such damage is associated with clinical disability. Copyright © 2011 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/134436
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
Funding AgencyGrant Number
URC
Funding Information:

Contract grant sponsor: URC Seed Funding Program.

References
Errata

 

DC FieldValueLanguage
dc.contributor.authorQian, Wen_HK
dc.contributor.authorChan, Qen_HK
dc.contributor.authorMak, Hen_HK
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorAnthony, MPen_HK
dc.contributor.authorYau, KKWen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorKim, Men_HK
dc.date.accessioned2011-06-17T09:20:33Z-
dc.date.available2011-06-17T09:20:33Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2011, v. 33 n. 6, p. 1312-1320en_HK
dc.identifier.issn1053-1807en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134436-
dc.description.abstractPurpose: To investigate whether quantitative MRI measures of cervical spinal cord white matter (WM) using diffusion tensor imaging (DTI) in neuromyelitis optica (NMO) differed from controls and correlated with clinical disability. Materials and Methods: Ten referred patients and 12 healthy volunteers were imaged on a 3 Tesla scanner and patients were clinically assessed on the Expanded Disability Status Scale (EDSS). Two raters quantified DTI-derived indices from all participants, including fractional anisotropy (FA), mean diffusivity (MD), parallel diffusivity (lambda[parallel]) and perpendicular diffusivity (lambda[perpendicular]) at C1-C6 for lateral and dorsal columns. After the inter-rater reliability test, univariate correlations between DTI measures and disability were assessed using the Spearman's rho correlation coefficient. Multiple regression analysis was performed to investigate which DTI measures independently correlated with the clinical score. Results: Statistical test results indicated high reliability of all DTI measurements between two raters. NMO patients showed reduced FA, increased MD and lambda[perpendicular] compared with controls while lambda[parallel] did not show any significant difference. The former three DTI metrics also showed significant correlations with disability scores, and especially FA was found to be sensitive to mild NMO (EDSS ≤ 3) Conclusion: FA is a potentially useful quantitative biomarker of otherwise normal appearing WM damage in NMO. Such damage is associated with clinical disability. Copyright © 2011 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_HK
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_HK
dc.rightsJournal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc.-
dc.subjectcervical spinal corden_HK
dc.subjectdiffusion tensor imagingen_HK
dc.subjectneuromyelitis opticaen_HK
dc.subject.meshAnisotropy-
dc.subject.meshBrain - pathology-
dc.subject.meshDiffusion Tensor Imaging - methods-
dc.subject.meshNeuromyelitis Optica - diagnosis - pathology-
dc.subject.meshSpinal Cord - pathology-
dc.titleQuantitative assessment of the cervical spinal cord damage in neuromyelitis optica using diffusion tensor imaging at 3 Teslaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-1807&volume=33&issue=6&spage=1312&epage=1320&date=2011&atitle=Quantitative+assessment+of+the+cervical+spinal+cord+damage+in+neuromyelitis+optica+using+diffusion+tensor+imaging+at+3+Tesla-
dc.identifier.emailMak, H: makkf@hkucc.hku.hken_HK
dc.identifier.emailAnthony, MP: anthonym@hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailKim, M: minakim@hku.hken_HK
dc.identifier.authorityMak, H=rp00533en_HK
dc.identifier.authorityAnthony, MP=rp01302en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityKim, M=rp00292en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmri.22575en_HK
dc.identifier.pmid21590999-
dc.identifier.scopuseid_2-s2.0-79958247202en_HK
dc.identifier.hkuros185799en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79958247202&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1312en_HK
dc.identifier.epage1320en_HK
dc.identifier.isiWOS:000291267700005-
dc.publisher.placeUnited Statesen_HK
dc.relation.erratumdoi:10.1002/jmri.22702-
dc.identifier.scopusauthoridQian, W=53364184800en_HK
dc.identifier.scopusauthoridChan, Q=6602497305en_HK
dc.identifier.scopusauthoridMak, H=7004699149en_HK
dc.identifier.scopusauthoridZhang, Z=53364835700en_HK
dc.identifier.scopusauthoridAnthony, MP=35270974300en_HK
dc.identifier.scopusauthoridYau, KKW=7101941425en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridChan, KH=7406034963en_HK
dc.identifier.scopusauthoridKim, M=8146283400en_HK

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