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Article: Two missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese
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TitleTwo missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese
 
AuthorsZhang, Y2
Yang, W2
Mok, CC3
Chan, TM2
Wong, RWS2
Mok, MY2
Lee, KW5
Wong, SN3
Leung, AMH4
Lee, TL2
Ho, MHK2
Lee, PPW2
Wong, WHS2
Yang, J2
Zhang, J2
Wong, CM1
Ng, IOL1
GarciaBarceló, MM1
Cherny, SS1
Tam, PKH1
Sham, PC1
Lau, CS2
Lau, YL2
 
KeywordsAsian
association
SLE
UHRF1BP1
 
Issue Date2011
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
 
CitationGenes And Immunity, 2011, v. 12 n. 3, p. 231-234 [How to Cite?]
DOI: http://dx.doi.org/10.1038/gene.2010.66
 
AbstractUHRF1BP1 encodes a highly conserved protein with unknown function. Previously, a coding variant in this gene was found to be associated with systemic lupus erythematosus (SLE) in populations of European ancestry (rs11755393, R454Q, P=2.22 × 10 -8, odds ratio=1.17). In this study, by a combination of genome-wide study and replication involving a total of 1230 patients and 3144 controls, we confirmed the association of this coding variant to SLE in Hong Kong Chinese. We also identified another coding variant in this gene that independently contributes to SLE susceptibility (rs13205210, M1098T, P=4.44 × 10 -9, odds ratio1.49). Cross-population confirmation establishes the involvement of this locus in SLE and indicates that distinct alleles are contributing to disease susceptibility. © 2011 Macmillan Publishers Limited All rights reserved.
 
ISSN1466-4879
2013 Impact Factor: 3.789
 
DOIhttp://dx.doi.org/10.1038/gene.2010.66
 
ISI Accession Number IDWOS:000289832900010
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Research Grant Council of the Hong Kong GovernmentGRF HKU781709M
Edward the Sai Kim Hotung Paediatric Education and Research Fund
University Postgraduate Studentship
Funding Information:

This study was partially supported by the generous donation from Shun Tak District Min Yuen Tong of Hong Kong (to YLL). WY thanks support from Research Grant Council of the Hong Kong Government (GRF HKU781709M). YZ is supported by Edward the Sai Kim Hotung Paediatric Education and Research Fund and University Postgraduate Studentship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, Y
 
dc.contributor.authorYang, W
 
dc.contributor.authorMok, CC
 
dc.contributor.authorChan, TM
 
dc.contributor.authorWong, RWS
 
dc.contributor.authorMok, MY
 
dc.contributor.authorLee, KW
 
dc.contributor.authorWong, SN
 
dc.contributor.authorLeung, AMH
 
dc.contributor.authorLee, TL
 
dc.contributor.authorHo, MHK
 
dc.contributor.authorLee, PPW
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorYang, J
 
dc.contributor.authorZhang, J
 
dc.contributor.authorWong, CM
 
dc.contributor.authorNg, IOL
 
dc.contributor.authorGarciaBarceló, MM
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorTam, PKH
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLau, CS
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2011-05-24T02:13:47Z
 
dc.date.available2011-05-24T02:13:47Z
 
dc.date.issued2011
 
dc.description.abstractUHRF1BP1 encodes a highly conserved protein with unknown function. Previously, a coding variant in this gene was found to be associated with systemic lupus erythematosus (SLE) in populations of European ancestry (rs11755393, R454Q, P=2.22 × 10 -8, odds ratio=1.17). In this study, by a combination of genome-wide study and replication involving a total of 1230 patients and 3144 controls, we confirmed the association of this coding variant to SLE in Hong Kong Chinese. We also identified another coding variant in this gene that independently contributes to SLE susceptibility (rs13205210, M1098T, P=4.44 × 10 -9, odds ratio1.49). Cross-population confirmation establishes the involvement of this locus in SLE and indicates that distinct alleles are contributing to disease susceptibility. © 2011 Macmillan Publishers Limited All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationGenes And Immunity, 2011, v. 12 n. 3, p. 231-234 [How to Cite?]
DOI: http://dx.doi.org/10.1038/gene.2010.66
 
dc.identifier.citeulike8849564
 
dc.identifier.doihttp://dx.doi.org/10.1038/gene.2010.66
 
dc.identifier.epage234
 
dc.identifier.hkuros185393
 
dc.identifier.hkuros200693
 
dc.identifier.isiWOS:000289832900010
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Research Grant Council of the Hong Kong GovernmentGRF HKU781709M
Edward the Sai Kim Hotung Paediatric Education and Research Fund
University Postgraduate Studentship
Funding Information:

This study was partially supported by the generous donation from Shun Tak District Min Yuen Tong of Hong Kong (to YLL). WY thanks support from Research Grant Council of the Hong Kong Government (GRF HKU781709M). YZ is supported by Edward the Sai Kim Hotung Paediatric Education and Research Fund and University Postgraduate Studentship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 
dc.identifier.issn1466-4879
2013 Impact Factor: 3.789
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid21326321
 
dc.identifier.scopuseid_2-s2.0-79955464760
 
dc.identifier.spage231
 
dc.identifier.urihttp://hdl.handle.net/10722/133657
 
dc.identifier.volume12
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofGenes and Immunity
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAsian
 
dc.subjectassociation
 
dc.subjectSLE
 
dc.subjectUHRF1BP1
 
dc.titleTwo missense variants in UHRF1BP1 are independently associated with systemic lupus erythematosus in Hong Kong Chinese
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Tuen Mun Hospital
  4. Queen Elizabeth Hospital Hong Kong
  5. Pamela Youde Nethersole Eastern Hospital