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Article: Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
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TitleHomozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
 
AuthorsChan, VSF1
Chan, KYK1
Chen, Y1
Poon, LLM1
Cheung, ANY1
Zheng, B1
Chan, KH1
Mak, W1
Ngan, HYS1
Xu, X4
Screaton, G3
Tam, PKH1
Austyn, JM2
Chan, LC1
Yip, SP5
Peiris, M1
Khoo, US1
Lin, CLS1
 
KeywordsSpecies Index: Animalia
Coronavirus
Sars Coronavirus
 
Issue Date2006
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
 
CitationNature Genetics, 2006, v. 38 n. 1, p. 38-46 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ng1698
 
AbstractSevere acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection. © 2006 Nature Publishing Group.
 
ISSN1061-4036
2013 Impact Factor: 29.648
2013 SCImago Journal Rankings: 24.052
 
DOIhttp://dx.doi.org/10.1038/ng1698
 
ISI Accession Number IDWOS:000234227200015
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, VSF
 
dc.contributor.authorChan, KYK
 
dc.contributor.authorChen, Y
 
dc.contributor.authorPoon, LLM
 
dc.contributor.authorCheung, ANY
 
dc.contributor.authorZheng, B
 
dc.contributor.authorChan, KH
 
dc.contributor.authorMak, W
 
dc.contributor.authorNgan, HYS
 
dc.contributor.authorXu, X
 
dc.contributor.authorScreaton, G
 
dc.contributor.authorTam, PKH
 
dc.contributor.authorAustyn, JM
 
dc.contributor.authorChan, LC
 
dc.contributor.authorYip, SP
 
dc.contributor.authorPeiris, M
 
dc.contributor.authorKhoo, US
 
dc.contributor.authorLin, CLS
 
dc.date.accessioned2011-03-28T09:25:26Z
 
dc.date.available2011-03-28T09:25:26Z
 
dc.date.issued2006
 
dc.description.abstractSevere acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection. © 2006 Nature Publishing Group.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationNature Genetics, 2006, v. 38 n. 1, p. 38-46 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ng1698
 
dc.identifier.citeulike451561
 
dc.identifier.doihttp://dx.doi.org/10.1038/ng1698
 
dc.identifier.eissn1546-1718
 
dc.identifier.epage46
 
dc.identifier.hkuros112904
 
dc.identifier.isiWOS:000234227200015
 
dc.identifier.issn1061-4036
2013 Impact Factor: 29.648
2013 SCImago Journal Rankings: 24.052
 
dc.identifier.issue1
 
dc.identifier.pmid16369534
 
dc.identifier.scopuseid_2-s2.0-29444444113
 
dc.identifier.spage38
 
dc.identifier.urihttp://hdl.handle.net/10722/132497
 
dc.identifier.volume38
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNature Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshCHO Cells - virology
 
dc.subject.meshCell Adhesion Molecules - genetics - metabolism
 
dc.subject.meshCercopithecus aethiops
 
dc.subject.meshCohort Studies
 
dc.subject.meshCricetinae
 
dc.subject.meshCricetulus
 
dc.subject.meshGenetic Predisposition to Disease
 
dc.subject.meshHomozygote
 
dc.subject.meshHong Kong - epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshIntestine, Small - physiology
 
dc.subject.meshLectins, C-Type - genetics - metabolism
 
dc.subject.meshLung - physiology - virology
 
dc.subject.meshMolecular Sequence Data
 
dc.subject.meshProteasome Endopeptidase Complex - metabolism
 
dc.subject.meshReceptors, Cell Surface - genetics - metabolism
 
dc.subject.meshSARS Virus - metabolism - pathogenicity
 
dc.subject.meshSevere Acute Respiratory Syndrome - epidemiology - genetics
 
dc.subject.meshTandem Repeat Sequences
 
dc.subject.meshVero Cells - virology
 
dc.subjectSpecies Index: Animalia
 
dc.subjectCoronavirus
 
dc.subjectSars Coronavirus
 
dc.titleHomozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Nuffield Department of Clinical Medicine
  3. Imperial College London
  4. Weatherall Institute of Molecular Medicine
  5. Hong Kong Polytechnic University