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Article: Mitochondrial targeting of growth suppressor protein DLC2 through the START domain

TitleMitochondrial targeting of growth suppressor protein DLC2 through the START domain
Authors
Ng, DCHChan, SFKok, KHYam, JWPChing, YPNg, IOLJin, DY
KeywordsDeleted in liver cancer 2
Growth suppressor protein
Hepatocellular carcinoma
Lipid droplets
Mitochondria
Steroidogenic acute regulatory protein-related lipid transfer domain
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2006, v. 580 n. 1, p. 191-198 How to Cite?
DOI: http://dx.doi.org/10.1016/j.febslet.2005.11.073
AbstractDeleted in liver cancer 2 (DLC2) is a candidate tumor suppressor frequently found to be deleted in hepatocellular carcinoma. In this study, we determined the subcellular localization of DLC2. Co-localization and biochemical fractionation studies revealed that DLC2 localized to mitochondria. In addition, the DLC2-containing cytoplasmic speckles were in proximity to lipid droplets. A DLC2 mutant containing the steroidogenic acute regulatory protein-related lipid transfer (START) domain only showed a localization pattern identical to that of DLC2. Taken together, we have provided the first evidence for mitochondrial localization of DLC2 through the START domain. These findings might have implications in liver physiology and carcinogenesis. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/132362
ISSN
0014-5793
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.208
ISI Accession Number ID
WOS:000234605100034
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorNg, DCHen_HK
dc.contributor.authorChan, SFen_HK
dc.contributor.authorKok, KHen_HK
dc.contributor.authorYam, JWPen_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2011-03-28T09:23:35Z-
dc.date.available2011-03-28T09:23:35Z-
dc.date.issued2006en_HK
dc.identifier.citationFebs Letters, 2006, v. 580 n. 1, p. 191-198en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132362-
dc.description.abstractDeleted in liver cancer 2 (DLC2) is a candidate tumor suppressor frequently found to be deleted in hepatocellular carcinoma. In this study, we determined the subcellular localization of DLC2. Co-localization and biochemical fractionation studies revealed that DLC2 localized to mitochondria. In addition, the DLC2-containing cytoplasmic speckles were in proximity to lipid droplets. A DLC2 mutant containing the steroidogenic acute regulatory protein-related lipid transfer (START) domain only showed a localization pattern identical to that of DLC2. Taken together, we have provided the first evidence for mitochondrial localization of DLC2 through the START domain. These findings might have implications in liver physiology and carcinogenesis. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.rightsF E B S Letters. Copyright © Elsevier BV.-
dc.subjectDeleted in liver cancer 2en_HK
dc.subjectGrowth suppressor proteinen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectLipid dropletsen_HK
dc.subjectMitochondriaen_HK
dc.subjectSteroidogenic acute regulatory protein-related lipid transfer domainen_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - metabolismen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshCell Transformation, Neoplastic - genetics - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver - metabolismen_HK
dc.subject.meshLiver Neoplasms - genetics - metabolismen_HK
dc.subject.meshMitochondria, Liver - genetics - metabolismen_HK
dc.subject.meshPhosphoproteins - genetics - metabolismen_HK
dc.subject.meshProtein Structure, Tertiary - geneticsen_HK
dc.subject.meshProtein Transport - geneticsen_HK
dc.subject.meshRecombinant Fusion Proteins - genetics - metabolismen_HK
dc.subject.meshTumor Suppressor Proteins - genetics - metabolismen_HK
dc.titleMitochondrial targeting of growth suppressor protein DLC2 through the START domainen_HK
dc.typeArticleen_HK
dc.identifier.emailKok, KH:khkok@hku.hken_HK
dc.identifier.emailYam, JWP:judyyam@pathology.hku.hken_HK
dc.identifier.emailChing, YP:ypching@hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityKok, KH=rp01455en_HK
dc.identifier.authorityYam, JWP=rp00468en_HK
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.febslet.2005.11.073en_HK
dc.identifier.pmid16364308-
dc.identifier.scopuseid_2-s2.0-29344433467en_HK
dc.identifier.hkuros114073-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29344433467&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume580en_HK
dc.identifier.issue1en_HK
dc.identifier.spage191en_HK
dc.identifier.epage198en_HK
dc.identifier.isiWOS:000234605100034-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridNg, DCH=36981535100en_HK
dc.identifier.scopusauthoridChan, SF=7404255795en_HK
dc.identifier.scopusauthoridKok, KH=7006862631en_HK
dc.identifier.scopusauthoridYam, JWP=6603711123en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK
dc.identifier.issnl0014-5793-

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