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Conference Paper: Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B

TitleIndependent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
The 43rd Annual Meeting of the European Association for the Study of the Liver (The International Liver Congress™ 2008), Milan, Italy, 23–27 April 2008. In Journal of Hepatology, 2008, v. 48 suppl. 2, p. S252, abstract no. 678 How to Cite?
AbstractBACKGROUND AND AIM: To determine whether gender, age, HBV genotype, core promoter and precore mutations, HBeAg/anti-HBe status, HBV DNA and ALT levels and cirrhosis on presentation were independent risk factors and derive a novel risk score for HCC development. METHODS: 820 patients with the above parameters checked were followed up (mean 76.8 months) for the HCC occurrence. RESULTS: Cox regression analysis showed that male [p = 0.025, relative risk (RR) 2.98], increasing age (p84%; specificity >76%) to predict the 5- and 10-year risks for HCC development. The AUC for the 5- and 10-year prediction were 0.88 and 0.89 respectively. CONCLUSIONS: The risk score, based on age, gender, HBV DNA levels, core promoter mutations and cirrhosis, can estimate the 5 and 10 years chance of HCC development. It can be used to identify high-risk CHB patients for treatment and screening of HCC.
Persistent Identifierhttp://hdl.handle.net/10722/102550
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570

 

DC FieldValueLanguage
dc.contributor.authorYuen, RMFen_HK
dc.contributor.authorTanaka, Yen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorFung, JYYen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorYuen, JCHen_HK
dc.contributor.authorBut, Den_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorMizokami, Men_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-25T20:35:11Z-
dc.date.available2010-09-25T20:35:11Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 43rd Annual Meeting of the European Association for the Study of the Liver (The International Liver Congress™ 2008), Milan, Italy, 23–27 April 2008. In Journal of Hepatology, 2008, v. 48 suppl. 2, p. S252, abstract no. 678en_HK
dc.identifier.issn0168-8278en_HK
dc.identifier.urihttp://hdl.handle.net/10722/102550-
dc.description.abstractBACKGROUND AND AIM: To determine whether gender, age, HBV genotype, core promoter and precore mutations, HBeAg/anti-HBe status, HBV DNA and ALT levels and cirrhosis on presentation were independent risk factors and derive a novel risk score for HCC development. METHODS: 820 patients with the above parameters checked were followed up (mean 76.8 months) for the HCC occurrence. RESULTS: Cox regression analysis showed that male [p = 0.025, relative risk (RR) 2.98], increasing age (p84%; specificity >76%) to predict the 5- and 10-year risks for HCC development. The AUC for the 5- and 10-year prediction were 0.88 and 0.89 respectively. CONCLUSIONS: The risk score, based on age, gender, HBV DNA levels, core promoter mutations and cirrhosis, can estimate the 5 and 10 years chance of HCC development. It can be used to identify high-risk CHB patients for treatment and screening of HCC.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhepen_HK
dc.relation.ispartofJournal of Hepatologyen_HK
dc.rightsJournal of Hepatology. Copyright © Elsevier BV.en_HK
dc.titleIndependent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis Ben_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=48 &issue=Suppl 2&spage=S252&epage=&date=2008&atitle=Independent+risk+factors+and+predictive+score+for+the+development+of+hepatocellular+carcinoma+in+chronic+hepatitis+Ben_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.emailFung, JYY: jfung@sicklehut.comen_HK
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailYuen, JCH: jchyuen@HKUCC.hku.hken_HK
dc.identifier.emailChan, AOO: aoochan@hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.identifier.authorityFung, JYY=rp00518en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0168-8278(08)60680-7-
dc.identifier.hkuros152611en_HK
dc.identifier.volume48en_HK
dc.identifier.issuesuppl. 2en_HK
dc.identifier.spageS252, abstract no. 678en_HK
dc.identifier.epageS252, abstract no. 678-

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