Yeung, WSB

Email Alert RSS Feed

 

Name Card
rp00331 picture

Professor Yeung, William Shu Biu 楊樹標

Title:
Honorary Professor
Professor

Contact Information
rp00331 picture
Tel:
2255 4052
Office:

Professor Yeung, William Shu Biu 楊樹標

Title:
Honorary Professor
Professor

Also Cited As:
Yeung, SB
Yeung, Shu-biu, William
Yeung, Shu-Biu

Biography

I have three main areas of research interest, namely regulation of fertilization, microRNAs in reproduction and stem cells.

My interest on regulation of fertilization started with my identification of a novel glycoprotein, later named as glycodelin-F in the human follicular fluid that inhibited the binding of human spermatozoa with zona pellucida of oocytes.  Later, we found another isoform of glycodelin in the human cumulus matrix that stimulated the binding.  The difference in biological activities of glycodelin isoforms depend on their glycosylation, as all the glycodelin isoforms contain the protein core.  We had also identified one of the receptors of glycodelin in human sperm responsible for the spermatozoa- zona pellucida binding (Chiu et al., 2007, J Cell Sci 120, 33-44), and in human trophoblast for modulating the invasiveness of the cells (Lam et al., 2011, J Biol Chem 286, 37118-27).  Clinically, pathological change in the glycosylation of glycodelin as in gestation diabetes mellitus is associated with a change in the immunosuppressive activities of the amniotic isoform of glycodelin (Lee et al, 2011, Diabetes 60, 909-17).  The results of glycodelins demonstrate the importance of glycosylation in spermatozoa-zona pellucida interaction.  Therefore, we studied the glycan profile of human zona pelluida in collaboration with Professor A. Dell, Imperial College, London.  The result showed that a high percentage of the glycans on the zona pellucida contained a structure known as sialy Lewis x, which when being blocked reduced the spermatozoa-zona pellucida binding by about 70% (Pang et al., 2011, Science 333, 1761-64).

The second research interest is on microRNAs in reproduction. We have recently provided the first evidence that microRNAs in spermatozoa are important for cleavage of the mouse zygotes (Liu et al., 2012, PNAS, 109, 490-4).  We also showed that microRNAs in mouse preimplantation embryos modulate implantation (Liu et al., 2012, PLoS One, 7, e37039) and activation of dormant blastocysts (Cheong et al, 2014, Hum Reprod 2014 Jan 12 [Epub]).

The third research interest is on stem cells.  We recently reported the presence of stem/progenitor cells in endometriotic tissue (Chan et al., 2011, Am J Pathol, 178, 2832-44).  Our data show that microRNAs regulate the formation of stem cells.  Sirt1 facilitates the formation of induced pluripotent stem cells from mouse fibroblasts and microRNA-34a is involved in the process (Lee et al., 2012, PLoS One, 7, e45633).  Forced-expression of microRNA-135a induces cervical tumoriogenesis (Leung et al., 2014, Carcinogenesis accepted) and formation of cells with cancer stem cell-like properties.

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
Pang, PC
Lee, CL
Chang, LY
Panico, M
Morris, HR
Haslam, SM
Khoo, KH
Clark, GF
Dell, A
2011-12-01Faculty of 1000 “Naturally Selected” on December 2011: Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida. Science. 2011;333(6050):1761-4.: Faculty of 1000Research Achievement
Liu, W
Lao, K
2010-05-01Excellent Poster Presentation: MicroRNA-34c is important for the first cell division in mouse embryos: First SKLAB Symposia on Frontiers in Preimplantation Biology 8-12 May 2010, BeijingResearch Achievement
Wong, CYG
2010-06-01Young Investigator’s Award – 3rd Congress of Asia Pacific Council on Contraception: Obstetrical and Gynaecological Society of Hong KongResearch Achievement
Leung, ON
Liu, W
2010-06-01Basic Science Award: MicroRNA-135a regulates early embryo development through mediating expression of E3 Ubiquitin Ligase Seven In Absentia Homolog 1 (SIAH1): 26th Annual Meeting of European Society for Reproduction and Embryology, 27-30 June 2010, RomeResearch Achievement
WONG, CW
Lam, KW
2014-10-01IBSA poster prize: The roles of ERp57 and surface thiol/disulphide exchange in spermatozoa-zona pellucida binding: 8th European Congress of Andrology, Barcelona, SpainResearch Achievement
Lee, CL
Pang, PC
Koistinen, R
Koistinen, H
Seppala, M
Morris, HR
Tissot, B
Panico, M
Dell, A
2011-08-01HKU Strategic Research Areas & Themes “Reproduction and Development” Best Research Output Award 2011 (2nd Prize): Glycosylation failure extends to glycoproteins in gestational diabetes: Evidence from reduced alpha 2-6 sialylation and impaired immunomodulatory activities of pregnancy-related glycodelin-A. Diabetes. 2011;60(3):909-17.: HKU Strategic Research Areas & Themes “Reproduction and Development”Research Achievement
CHEONG, WYA
Liu, W
2013-07-01Concomitant Regulatory Effect of Lin28 and Dicer on MicroRNA Let-7a Expression Alters the State of the Blastocysts During Embryo Implantation: Regional Best Abstract Award (Southeast Asia) - Society for the Study of Reproduction, USAResearch Achievement
Chung, MK
Lam, KW
Lee, CL
2008-11-01Best Poster Award: Cumulus glycodelin stimulates human spermatozoa-zona binding mediated by the elevation of intracellular calcium concentration: The Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, 30 November 2008, Hong Kong.Research Achievement
LEUNG, ON
Liu, W
2010-06-01MicroRNA-135a Regulates Early Embryo Development Through Mediating Expression of E3 Ubiquitin Ligase Seven In Absentia Homolog 1 (SIAH1): The 26th Annual Meeting of the European Society of Human Reproduction and Embryology.Research Achievement
Lam, KW
Lee, CL
Chung, MK
2008-11-01Best Oral Presentation Award: Glycodelin-A suppresses human extravillous cytotrophoblast invasion through modulating matrix metalloproteinases activities.: The Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, 30 November 2008, Hong Kong.Research Achievement
Cheong, WYA
Liu, Y
2007-11-01Best poster presentation award HKSEMR 2007- Oviductal microsomal epoxide hydrolase (Ephx1) enhances preimplantation embryo development by suppressing reactiveoxygen species (ROS) production.: The Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, 11 November 2007, Hong Kong.Research Achievement
Liu, W
2010-01-01Best Abstract Award: MicroRNA let-7 is important in embryo implantation: Annual Scientific Meeting of the Hong Kong Society for Reproductive Medicine 21 January 2010Research Achievement
Chow, JFC
Lau, EYL
2011-05-27The Young Investigator Award--Preimplantation genetic diagnosis of thalassemia using whole genome amplification and polymerase chain reaction: The 8th Conference of the Pacific Rim Society for Fertility and Sterility, organized by the Pacific Rim Society for Fertility and Sterility and The Hong Kong Society for Reproductive Medicine, May 27-29, 2011, Hong Kong Convention and Exhibition Centre.Research Achievement
Liu, W
Cheong, AWY
2012-05-01Excellent Poster Presentation: Involvement of microRNA Lethal-7a in the Regulation of Embryo Implantation in Mice: 2nd SKLRB Symposia on “Frontiers in Reproductive BiologyResearch Achievement
2011-05-01Best Poster Award - Ovarian stimulation modulates steroid receptors expression and spheroids attachment in peri-implantation endometria: studies on natural and stimulated cycles: Pacific Rim Society for Fertility and SterilityResearch Achievement
LI, T
LI, Y
2014-05-01Poster Award (Title of poster presentation: In-vitro study on the effect of ulipristal acetate on human embryo implantation using a trophoblastic spheroid and endometrial cell co-culture model): 13th Congress of the European Society of Contraception and Reproductive HealthResearch Achievement
2002-12-01Outstanding presentation award: The 7th Research Postgraduate Symposium, The University of Hong Kong, Dec 7, Hong Kong.Research Achievement
Yao, Y
2001-10-01A systematic study on the effect of human oviductal cells and follicular fluid on sperm function .: Third Prize on Technology Advancement, China Medical AssociationResearch Achievement
Ko, KYJ
HUANG, W
2013-10-01Ten best paper award: An in-vitro study of the effect of mifepristone and ulipristal acetate on human sperm functions.: Asian and Oceanic Congress of Obstetrics and Gynaecology, 20-23 October 2013, Bangkok, Thailand,Research Achievement
CHEONG, WYA
Liu, W
2012-11-01The estrogen-regulated Let-7a plays a pivotal role during blastocyst activation via its effect on Vav3: Best Oral Presentation award - The 7th Huaxia conferenceResearch Achievement
Professional Societies
Term PeriodPositionProfessional Societies
since 1995Memberalpha, an international society for embryologist
since 1995MemberThe New York Academy of Sciences, U.S.A.
since 1996MemberAmerican Association for the Advancement of Science, USA
2006-2008PresidentHong Kong Society of Endocrinology, Metabolism and Reproduction
2004-2006Vice-PresidentHong Kong Society of Endocrinology, Metabolism and Reproduction
2002-2004SecretaryHong Kong Society of Endocrinology, Metabolism and Reproduction
2000-2002Vice-PresidentHong Kong Society of Endocrinology, Metabolism and Reproduction
1998-2000Council memberHong Kong Society of Endocrinology, Metabolism and Reproduction
2008-2010Council memberHong Kong Society of Endocrinology, Metabolism and Reproduction
since 1988MemberSociety for the Study of Fertility, United Kingdom
since 1991MemberAmerican Society for Reproductive Medicine
2004-2006Council memberHong Kong Society for Reproductive Medicine
2000-2002TreasurerHong Kong Society for Reproductive Medicine
since 1993MemberEuropean Society for Human Reproduction and Embryology
since 1991MemberInstitute of Biology, United Kingdom
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!