Dr Cheung, Martin Chi Hang 張知恒
I obtained my bachelor degree in the Department of Biochemistry at the Chinese University of Hong Kong with a first class honor and then PhD in the University of Nottingham in U.K. Following postdoctoral training in the National Institute for Medical Research in U.K., I returned to Hong Kong in 2007 to join the Department of Biochemistry in HKU as Research Assistant Professor and became Assistant Professor in the Department of Anatomy since Nov 2013. My long-term research interest is to dissect the molecular mechanisms underlying the complex cell migration events using neural crest cells in chick embryo as a model system and whether similar regulatory control in conferring neural crest migratory capacity also governs cancer metastasis. My previous work has revealed a key role of Sox9 transcription factor in coordinating with zinc-finger transcriptional repressor, Snail2, for neural crest specification, survival and delamination. Recently, we further extended these findings and revealed a novel mecahnism by which BMP and canonical Wnt signaling control Sox9 phosphorylation which facilitates the co-operation with Snail2 to trigger the onset of neural crest delamination essential for the subsequent differentiation events. Our findings will provide an important molecular framework to understand how post-translational modifications would impart a regulatory role on Sox9 and other transcription factors in cancer metastasis and reveal new strategies for rational design of therapeutic agents to combat metastatic tumors.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2010-10-01||A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range: Research Output Prize, The University of Hong Kong||Research Achievement|
|Term Period||Position||Professional Societies|
|05/2012-present||Member||International Society for Stem Cell Research|
|6/2007-present||member||Hong Kong Society for Developmental Biology|
|9/1999-present||Member||British Society for Developmental Biology|
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