Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches


Grant Data
Project Title
Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Principal Investigator
Professor Yuen, Kwok Yung   (Principal investigator)
Co-Investigator(s)
Dr Lu Guangwen   (Co-Investigator)
Dr Qi Jianxun   (Co-Investigator)
Dr Yan Jinghua   (Co-Investigator)
Dr Chan Jasper Fuk Woo   (Co-Investigator)
Professor Lau Susanna Kar Pui   (Co-Investigator)
Professor Woo Patrick Chiu Yat   (Co-Investigator)
Professor Gao George Fu   (Co-principal investigator)
Duration
48
Start Date
2015-01-01
Completion Date
2018-12-31
Amount
1098911
Conference Title
Presentation Title
Keywords
batacoronavirus, evolution, transmission, structure, receptor, spike
Discipline
Structural Biology,Infection/Parasitology
Panel
Medicine
Sponsor
NSFC/RGC Joint Research Scheme
HKU Project Code
N_HKU728/14
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2014/2015
Status
On-going
Objectives
1) To understand the evolution and interspecies transmission of betacoronaviruses (╬▓CoVs) by identifying and characterizing the structural and functional features of their Spike protein variants identified in our bat surveillance program in mainland China and Hong Kong. 2) To identify and characterize the receptor-recognition of representative ╬▓CoVs that are of clinical importance to human or animals, such as human CoV-HKU1 and CoV-HKU9, by cocrystallization and protein-binding assays.