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Conference Paper: An analysis of acute and follow-up HRCT features in 23 cases of Cryptogenic Organizing Pneumonia (COP)
Title | An analysis of acute and follow-up HRCT features in 23 cases of Cryptogenic Organizing Pneumonia (COP) |
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Authors | |
Issue Date | 2005 |
Publisher | Lippincott Williams & Wilkins Inc. |
Citation | The 1st World Congress on Thoracic Imaging and Diagnosis in Chest Disease, Florence, Italy, 7-10 May 2005. In Journal of Thoracic Imaging, 2005, v. 20 n. 2, p. 149-150 How to Cite? |
Abstract | Aims: To evaluate spectrum of HRCT features at presentation, incidence of
fibrosis and pattern associated with fibrosis in COP.
Methods: All patients with biopsy proven COP (1992–2004) with full
complement of HRCT scans, and clinical data were recruited. HRCT scans
were evaluated for major pattern of lung abnormalities at presentation:
airspace, reticular, nodular, mass-like/focal, perilobular and mixed pattern
(combination of any of above). Air-space was defined by confluent, patchy/random,
bronchocentric, and segmental/lobar consolidation, and ground glass
opacities. Reticular opacities, intralobular septal thickening, honeycomb,
architectural distortion, volume loss and traction bronchiectasis defined
fibrosis. Clinical data were retrieved from institutional database and case notes.
Results: Of 23 patients [14M, 49.9 6 16.1 yrs], 2 were lost to follow-up,
5 died from other causes. Co-morbidities were haematological malignancies
(n = 6), autoimmune disorders (7), and carcinoma (2). Duration of clinical
follow-up was 50.7 6 44.9 (1–129) months in 21 patients. 17 patients
underwent serial scans [35.9 6 31.6 (7–192) months]. 4 patients relapsed.
Major patterns at presentation were airspace (9), reticular (0), nodular (2),
mass-like (3), perilobular (2) and mixed (7). Reticular opacities were noted
with other patterns in 8 patients. Fibrosis was evident in 8 patients; residual
parenchymal bands/minimal reticulation in 6, and complete resolution in 3.
Reticular opacities (p , 0.05) and mixed pattern at presentation (p , 0.05) was associated with fibrosis on follow-up. Co-morbidity, relapse and age
had no association with fibrosis, which developed in 3/8 (37%) patients with
airspace pattern, and none with mass-like pattern.
Conclusion: COP presents with spectrum of lung abnormalities. Airspace and
mixed patterns are commonest. Nodular, perilobular and mass-like
presentations are uncommon. Presence of reticular opacities and mixed
pattern are associated with development of fibrosis in COP. |
Persistent Identifier | http://hdl.handle.net/10722/98720 |
ISSN | 2023 Impact Factor: 2.0 2023 SCImago Journal Rankings: 0.722 |
DC Field | Value | Language |
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dc.contributor.author | Ooi, CGC | en_HK |
dc.contributor.author | Khong, PL | en_HK |
dc.contributor.author | Wong, M | en_HK |
dc.contributor.author | Tsang, KWT | en_HK |
dc.date.accessioned | 2010-09-25T17:59:28Z | - |
dc.date.available | 2010-09-25T17:59:28Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | The 1st World Congress on Thoracic Imaging and Diagnosis in Chest Disease, Florence, Italy, 7-10 May 2005. In Journal of Thoracic Imaging, 2005, v. 20 n. 2, p. 149-150 | - |
dc.identifier.issn | 0883-5993 | - |
dc.identifier.uri | http://hdl.handle.net/10722/98720 | - |
dc.description.abstract | Aims: To evaluate spectrum of HRCT features at presentation, incidence of fibrosis and pattern associated with fibrosis in COP. Methods: All patients with biopsy proven COP (1992–2004) with full complement of HRCT scans, and clinical data were recruited. HRCT scans were evaluated for major pattern of lung abnormalities at presentation: airspace, reticular, nodular, mass-like/focal, perilobular and mixed pattern (combination of any of above). Air-space was defined by confluent, patchy/random, bronchocentric, and segmental/lobar consolidation, and ground glass opacities. Reticular opacities, intralobular septal thickening, honeycomb, architectural distortion, volume loss and traction bronchiectasis defined fibrosis. Clinical data were retrieved from institutional database and case notes. Results: Of 23 patients [14M, 49.9 6 16.1 yrs], 2 were lost to follow-up, 5 died from other causes. Co-morbidities were haematological malignancies (n = 6), autoimmune disorders (7), and carcinoma (2). Duration of clinical follow-up was 50.7 6 44.9 (1–129) months in 21 patients. 17 patients underwent serial scans [35.9 6 31.6 (7–192) months]. 4 patients relapsed. Major patterns at presentation were airspace (9), reticular (0), nodular (2), mass-like (3), perilobular (2) and mixed (7). Reticular opacities were noted with other patterns in 8 patients. Fibrosis was evident in 8 patients; residual parenchymal bands/minimal reticulation in 6, and complete resolution in 3. Reticular opacities (p , 0.05) and mixed pattern at presentation (p , 0.05) was associated with fibrosis on follow-up. Co-morbidity, relapse and age had no association with fibrosis, which developed in 3/8 (37%) patients with airspace pattern, and none with mass-like pattern. Conclusion: COP presents with spectrum of lung abnormalities. Airspace and mixed patterns are commonest. Nodular, perilobular and mass-like presentations are uncommon. Presence of reticular opacities and mixed pattern are associated with development of fibrosis in COP. | - |
dc.language | eng | en_HK |
dc.publisher | Lippincott Williams & Wilkins Inc. | - |
dc.relation.ispartof | Journal of Thoracic Imaging | en_HK |
dc.title | An analysis of acute and follow-up HRCT features in 23 cases of Cryptogenic Organizing Pneumonia (COP) | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Ooi, CGC: cgcooi@hkucc.hku.hk | en_HK |
dc.identifier.email | Khong, PL: plkhong@hkucc.hku.hk | en_HK |
dc.identifier.email | Tsang, KWT: kwttsang@hku.hk | en_HK |
dc.identifier.authority | Khong, PL=rp00467 | en_HK |
dc.identifier.hkuros | 106366 | en_HK |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 149 | - |
dc.identifier.issnl | 0883-5993 | - |