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Article: Oxidative dissolution of silver nanoparticles by biologically relevant oxidants: A kinetic and mechanistic study
Title | Oxidative dissolution of silver nanoparticles by biologically relevant oxidants: A kinetic and mechanistic study | ||||
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Authors | |||||
Keywords | AgNPs. Nanostructures Kinetics Nanoparticles Oxidation Silver | ||||
Issue Date | 2010 | ||||
Publisher | Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451 | ||||
Citation | Chemistry - An Asian Journal, 2010, v. 5 n. 2, p. 285-293 How to Cite? | ||||
Abstract | The oxidative dissolution of silver nanoparticles (AgNPs) plays an important role in the synthesis of welldefined nanostructured materials, and may be responsible for their activities in biological systems. In this study, we use stopped-flow spectrophotometry to investigate the kinetics and mechanism of the oxidative dissolution of AgNPs by H 2O 2 in quasi-physiological conditions. Our results show that the reaction is first order with respect to both [Ag 0] and [H 2O 2], and parallel pathways that involve the oxidation of H 2O 2 and HO 2 - are proposed. The order of the reaction is independent of the size of the AgNPs (≈5-20 nm). The rate of dissolution increases with increasing pH from 6.0 to 8.5. At 298 K and I=0.1m, the value of k b is five orders of magnitude higher than that of k a (where k a and k b are the rate constants for the oxidative dissolution of AgNPs by H 2O 2 and HO 2 -, respectively). In addition, the effects of surface coating and the presence of halide ions on the dissolution rates are investigated. A possible mechanism for the oxidative dissolution of AgNPs by H 2O 2 is proposed. We further demonstrate that the toxicities of AgNPs in both bacteria and mammalian cells are enhanced in the presence of H 2O 2, thereby highlighting the biological relevance of investigating the oxidative dissolution of AgNPs. © 2010 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. | ||||
Persistent Identifier | http://hdl.handle.net/10722/97360 | ||||
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.846 | ||||
ISI Accession Number ID |
Funding Information: This work was supported by the Hong Kong Research Grants Council (HKU 7029/09) and the Area of Excellence (AoE/P 10/01) established under the University Grants Committee of the Hong Kong SAR. We are grateful to Professor T.-C. Lau of City Univeisity of Hong, Kong for access to the equipment for kinetic measurements and Dr. Rory Wait for his help in editing this Manuscript. We thank one reviewer for making suggestions on the oxidative dissolution rates. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ho, CM | en_HK |
dc.contributor.author | Yau, SKW | en_HK |
dc.contributor.author | Lok, CN | en_HK |
dc.contributor.author | So, MH | en_HK |
dc.contributor.author | Che, CM | en_HK |
dc.date.accessioned | 2010-09-25T17:06:06Z | - |
dc.date.available | 2010-09-25T17:06:06Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Chemistry - An Asian Journal, 2010, v. 5 n. 2, p. 285-293 | en_HK |
dc.identifier.issn | 1861-4728 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/97360 | - |
dc.description.abstract | The oxidative dissolution of silver nanoparticles (AgNPs) plays an important role in the synthesis of welldefined nanostructured materials, and may be responsible for their activities in biological systems. In this study, we use stopped-flow spectrophotometry to investigate the kinetics and mechanism of the oxidative dissolution of AgNPs by H 2O 2 in quasi-physiological conditions. Our results show that the reaction is first order with respect to both [Ag 0] and [H 2O 2], and parallel pathways that involve the oxidation of H 2O 2 and HO 2 - are proposed. The order of the reaction is independent of the size of the AgNPs (≈5-20 nm). The rate of dissolution increases with increasing pH from 6.0 to 8.5. At 298 K and I=0.1m, the value of k b is five orders of magnitude higher than that of k a (where k a and k b are the rate constants for the oxidative dissolution of AgNPs by H 2O 2 and HO 2 -, respectively). In addition, the effects of surface coating and the presence of halide ions on the dissolution rates are investigated. A possible mechanism for the oxidative dissolution of AgNPs by H 2O 2 is proposed. We further demonstrate that the toxicities of AgNPs in both bacteria and mammalian cells are enhanced in the presence of H 2O 2, thereby highlighting the biological relevance of investigating the oxidative dissolution of AgNPs. © 2010 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451 | en_HK |
dc.relation.ispartof | Chemistry - An Asian Journal | en_HK |
dc.subject | AgNPs. Nanostructures | en_HK |
dc.subject | Kinetics | en_HK |
dc.subject | Nanoparticles | en_HK |
dc.subject | Oxidation | en_HK |
dc.subject | Silver | en_HK |
dc.subject.mesh | Hydrogen Peroxide - chemistry | - |
dc.subject.mesh | Hydrogen-Ion Concentration | - |
dc.subject.mesh | Kinetics | - |
dc.subject.mesh | Metal Nanoparticles - chemistry | - |
dc.subject.mesh | Silver - chemistry | - |
dc.title | Oxidative dissolution of silver nanoparticles by biologically relevant oxidants: A kinetic and mechanistic study | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1861-4728&volume=5&issue=2&spage=285&epage=293&date=2010&atitle=Oxidative+Dissolution+of+Silver+Nanoparticles+by+Biologically+Relevant+Oxidants.+A+kinetic+and+Mechanistic+Study | - |
dc.identifier.email | Ho, CM: rickyho@hkucc.hku.hk | en_HK |
dc.identifier.email | Lok, CN: cnlok@hku.hk | en_HK |
dc.identifier.email | Che, CM: cmche@hku.hk | en_HK |
dc.identifier.authority | Ho, CM=rp00705 | en_HK |
dc.identifier.authority | Lok, CN=rp00752 | en_HK |
dc.identifier.authority | Che, CM=rp00670 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/asia.200900387 | en_HK |
dc.identifier.pmid | 20063340 | - |
dc.identifier.scopus | eid_2-s2.0-76149133133 | en_HK |
dc.identifier.hkuros | 168964 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-76149133133&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 5 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 285 | en_HK |
dc.identifier.epage | 293 | en_HK |
dc.identifier.isi | WOS:000274539100011 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Ho, CM=12807243800 | en_HK |
dc.identifier.scopusauthorid | Yau, SKW=26647235100 | en_HK |
dc.identifier.scopusauthorid | Lok, CN=7006410829 | en_HK |
dc.identifier.scopusauthorid | So, MH=9275915300 | en_HK |
dc.identifier.scopusauthorid | Che, CM=7102442791 | en_HK |
dc.identifier.issnl | 1861-471X | - |