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- Publisher Website: 10.1155/2008/951894
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- PMID: 18334738
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Article: Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
Title | Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese |
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Authors | |
Keywords | Fibrinogen Haplotype Impaired glucose tolerance Polymorphism |
Issue Date | 2008 |
Publisher | IOS Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.php |
Citation | Disease Markers, 2008, v. 24 n. 3, p. 167-173 How to Cite? |
Abstract | Fibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. © 2008 - IOS Press and the authors. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/91596 |
ISSN | 2021 Impact Factor: 3.464 2020 SCImago Journal Rankings: 0.912 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, LYF | en_HK |
dc.contributor.author | Ong, KL | en_HK |
dc.contributor.author | Cheung, BMY | en_HK |
dc.contributor.author | Leung, RYH | en_HK |
dc.contributor.author | Man, YB | en_HK |
dc.contributor.author | Lam, TH | en_HK |
dc.date.accessioned | 2010-09-17T10:21:56Z | - |
dc.date.available | 2010-09-17T10:21:56Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Disease Markers, 2008, v. 24 n. 3, p. 167-173 | en_HK |
dc.identifier.issn | 0278-0240 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/91596 | - |
dc.description.abstract | Fibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. © 2008 - IOS Press and the authors. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | IOS Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.php | en_HK |
dc.relation.ispartof | Disease Markers | en_HK |
dc.subject | Fibrinogen | en_HK |
dc.subject | Haplotype | en_HK |
dc.subject | Impaired glucose tolerance | en_HK |
dc.subject | Polymorphism | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Blood Glucose - analysis | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Fibrinogen - genetics | en_HK |
dc.subject.mesh | Genotype | en_HK |
dc.subject.mesh | Glucose Tolerance Test | en_HK |
dc.subject.mesh | Hong Kong | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_HK |
dc.subject.mesh | Regression Analysis | en_HK |
dc.title | Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Cheung, BMY:mycheung@hku.hk | en_HK |
dc.identifier.email | Lam, TH:hrmrlth@hkucc.hku.hk | en_HK |
dc.identifier.authority | Cheung, BMY=rp01321 | en_HK |
dc.identifier.authority | Lam, TH=rp00326 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1155/2008/951894 | - |
dc.identifier.pmid | 18334738 | - |
dc.identifier.pmcid | PMC3850617 | - |
dc.identifier.scopus | eid_2-s2.0-44449149913 | en_HK |
dc.identifier.hkuros | 180101 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-44449149913&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 24 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 167 | en_HK |
dc.identifier.epage | 173 | en_HK |
dc.identifier.isi | WOS:000254578600005 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Wong, LYF=24476809800 | en_HK |
dc.identifier.scopusauthorid | Ong, KL=8340854000 | en_HK |
dc.identifier.scopusauthorid | Cheung, BMY=7103294806 | en_HK |
dc.identifier.scopusauthorid | Leung, RYH=7101876102 | en_HK |
dc.identifier.scopusauthorid | Man, YB=10245005900 | en_HK |
dc.identifier.scopusauthorid | Lam, TH=7202522876 | en_HK |
dc.identifier.issnl | 0278-0240 | - |