Determination of peroxide value in sirolimus oral solution by potentiometric-iodometry

Abstract

Objective: To develop a method for the determination of peroxide value in sirolimus oral solution. Methods: A potentiometric - iodometry method was conducted. Sirolimus was dissolved in methanol, and excess volume of iodine titrant was added. The titration was carried out using (Chinese characters S2 Chinese characters) (Chinese characters 540 Chinese characters) Mettler DL67 automatic titrator with 0. 01mol/L sodium thiosulphate as blank titrant to reach the endpoint, with Mettler DM140-SC Electrode as potential indicator. In order to acquire the net content of peroxide value in oral solution, a blank determination was performed. Results: The method showed a smooth titration curve, high sensitivity and good reproducibility. Conclusions: The method was convenient and accurate. It provided a suitable method to determine the peroxide value in sirolimus oral solution.