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Article: BRCA1 and its toolbox for the maintenance of genome integrity

TitleBRCA1 and its toolbox for the maintenance of genome integrity
Authors
Huen, MSYSy, SMHChen, J
KeywordsChemicals And Cas Registry Numbers
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/molcellbio
Citation
Nature Reviews Molecular Cell Biology, 2010, v. 11 n. 2, p. 138-148 How to Cite?
DOI: http://dx.doi.org/10.1038/nrm2831
AbstractThe breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response. © 2010 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/90818
ISSN
1471-0072
2023 Impact Factor: 81.3
2023 SCImago Journal Rankings: 35.910
ISI Accession Number ID
WOS:000273811200014
Funding AgencyGrant Number
National Institutes of HealthCA089239
CA092312
CA100109
Department of Anatomy, The University of Hong Kong
Department of DefenceP50 CA116201
Funding Information:

This work was supported in part by grants from the National Institutes of Health (CA089239, CA092312 and CA100109 to J.C.), the Startup Fund (Department of Anatomy, The University of Hong Kong to M.S.Y.H.) and Seed Funding for Basic Research (The University of Hong Kong to M.S.Y.H.). J.C is a recipient of an Era of Hope Scholar award from the Department of Defence and a member of the Mayo Clinic Breast SPORE program (P50 CA116201).

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHuen, MSYen_HK
dc.contributor.authorSy, SMHen_HK
dc.contributor.authorChen, Jen_HK
dc.date.accessioned2010-09-17T10:08:51Z-
dc.date.available2010-09-17T10:08:51Z-
dc.date.issued2010en_HK
dc.identifier.citationNature Reviews Molecular Cell Biology, 2010, v. 11 n. 2, p. 138-148en_HK
dc.identifier.issn1471-0072en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90818-
dc.description.abstractThe breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response. © 2010 Macmillan Publishers Limited. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/molcellbioen_HK
dc.relation.ispartofNature Reviews Molecular Cell Biologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBRCA1 Protein - genetics - metabolismen_HK
dc.subject.meshCell Cycleen_HK
dc.subject.meshDNA Damageen_HK
dc.subject.meshDNA Repairen_HK
dc.subject.meshGenomic Instabilityen_HK
dc.subject.meshHumansen_HK
dc.titleBRCA1 and its toolbox for the maintenance of genome integrityen_HK
dc.typeArticleen_HK
dc.identifier.emailHuen, MSY:huen.michael@hku.hken_HK
dc.identifier.authorityHuen, MSY=rp01336en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nrm2831en_HK
dc.identifier.pmid20029420-
dc.identifier.scopuseid_2-s2.0-75149189204en_HK
dc.identifier.hkuros169511-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75149189204&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue2en_HK
dc.identifier.spage138en_HK
dc.identifier.epage148en_HK
dc.identifier.eissn1471-0080-
dc.identifier.isiWOS:000273811200014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHuen, MSY=23004751500en_HK
dc.identifier.scopusauthoridSy, SMH=6602984466en_HK
dc.identifier.scopusauthoridChen, J=7501899830en_HK
dc.identifier.citeulike6582021-
dc.identifier.issnl1471-0072-

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