Experimental Investigation on Effect of Rushuan Capsule in Relieving Hyperplasia of Mammary Gland and Pain

Abstract

目的 研究乳舒安膠囊抗乳腺增生和鎮痛作用 ,為臨床用藥提供實驗依據。方法 在抗乳腺增生實驗中采用肌肉注射苯甲醇雌二醇加肌注黃體酮造成大鼠乳腺增生模型 ,觀察乳舒胺膠囊灌胃給藥后對其治療作用 ;在鎮痛實驗中 ,采用小鼠扭體法及電刺激法 ,觀察乳舒安膠囊灌胃給藥后的鎮痛作用。結果 乳舒安膠囊能明顯降低大鼠血清雌二醇而升高孕酮的含量 ,恢復失衡的雌激素水平 ;明顯升高血清SOD活力、降低MDA的含量 ,具有抗氧化作用 ;明顯降低大鼠的乳頭高度 ,并能減小增生的乳腺腺泡體積 ,減輕導管擴張程度 ,減少分泌現象 ,各指標與模型組比較具有顯著性差異 (P<0 .0 5～ 0 .0 1)。乳舒安 7g/kg、14g/kg、2 8g/kg 3個劑量組能減輕由乙酸刺激所致的小鼠疼痛反應 (扭體反應 )和由電刺激致小鼠足跖疼痛反應 ,與空白對照組比較均有顯著性差異 (P <0 .0 5～ 0 .0 1)。結論 乳舒安具有較明顯的抗乳腺增生、鎮痛作用。 OBJECTIVE To investigate into the effect of Rushuan Capsule in relieving hyperplasia of mammary gland and pain. METHOD Benzestrofol, hidroestron and flavolutan were used to make mice and rat models to observe the effect of Rushuan Capsule. RESULT Rushuan Capsule could markedly relieve hyperplasia of mice mammary gland, with marked difference from the model group (P<0.05). Rushuan Capsule could also markedly reduce the content of corporin, restore the level of estrogen, markedly increase serum SOD activity, reduce MDA content, prevent oxidation, and reduce the volume of mammary gland alveolus, the degree of duct dilation and secretion, with marked difference from the model group (P<0.05～0.01). Rushuan at the dosages of 7g/kg, 14g/kg and 28g/kg could relieve mice painful reactions, with marked difference from the blank control group (P<0.05～0.01). CONCLUSION Rushuan Capsule has marked effect in relieving hyperplasia of mammary gland and pain.