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- Publisher Website: 10.2174/092986608783744216
- Scopus: eid_2-s2.0-41449091341
- PMID: 18336361
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Article: Stabilization of beta-propeller phytase by introducing Xaa→Pro and Gly→Ala substitutions at consensus positions
Title | Stabilization of beta-propeller phytase by introducing Xaa→Pro and Gly→Ala substitutions at consensus positions |
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Authors | |
Keywords | Beta-propeller phytase Proline Protein engineering Protein stability Unfolding entropy |
Issue Date | 2008 |
Publisher | Bentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ppl/index.htm |
Citation | Protein And Peptide Letters, 2008, v. 15 n. 3, p. 297-299 How to Cite? |
Abstract | Phytases play important roles in agricultural and feed industries. In this study, the stability of a beta-propeller phytase, PhyL, from Bacillus licheniformis was successfully improved by introducing Xaa→Pro and Gly→Ala substitutions at consensus positions. Our results suggest that Gly→Ala substitution is a more promising strategy to improve protein stability. © 2008 Bentham Science Publishers Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/89195 |
ISSN | 2023 Impact Factor: 1.0 2023 SCImago Journal Rankings: 0.349 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tung, ETK | en_HK |
dc.contributor.author | Ma, HW | en_HK |
dc.contributor.author | Cheng, C | en_HK |
dc.contributor.author | Lim, BL | en_HK |
dc.contributor.author | Wong, KB | en_HK |
dc.date.accessioned | 2010-09-06T09:53:43Z | - |
dc.date.available | 2010-09-06T09:53:43Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Protein And Peptide Letters, 2008, v. 15 n. 3, p. 297-299 | en_HK |
dc.identifier.issn | 0929-8665 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/89195 | - |
dc.description.abstract | Phytases play important roles in agricultural and feed industries. In this study, the stability of a beta-propeller phytase, PhyL, from Bacillus licheniformis was successfully improved by introducing Xaa→Pro and Gly→Ala substitutions at consensus positions. Our results suggest that Gly→Ala substitution is a more promising strategy to improve protein stability. © 2008 Bentham Science Publishers Ltd. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Bentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ppl/index.htm | en_HK |
dc.relation.ispartof | Protein and Peptide Letters | en_HK |
dc.subject | Beta-propeller phytase | - |
dc.subject | Proline | - |
dc.subject | Protein engineering | - |
dc.subject | Protein stability | - |
dc.subject | Unfolding entropy | - |
dc.subject.mesh | 6-Phytase - chemistry | en_HK |
dc.subject.mesh | Alanine - chemistry | en_HK |
dc.subject.mesh | Amino Acid Sequence | en_HK |
dc.subject.mesh | Amino Acid Substitution | en_HK |
dc.subject.mesh | Bacillus - enzymology | en_HK |
dc.subject.mesh | Consensus Sequence | en_HK |
dc.subject.mesh | Glycine - chemistry | en_HK |
dc.subject.mesh | Molecular Sequence Data | en_HK |
dc.subject.mesh | Proline - chemistry | en_HK |
dc.subject.mesh | Protein Structure, Tertiary | en_HK |
dc.subject.mesh | Sequence Alignment | en_HK |
dc.title | Stabilization of beta-propeller phytase by introducing Xaa→Pro and Gly→Ala substitutions at consensus positions | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0929-8665&volume=15&spage=297&epage=299&date=2008&atitle=Stabilization+of+beta-propeller+phytase+by+introducing+Xaa→Pro+and+Gly→Ala+substitutions+at+consensus+positions.+ | en_HK |
dc.identifier.email | Lim, BL: bllim@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lim, BL=rp00744 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2174/092986608783744216 | en_HK |
dc.identifier.pmid | 18336361 | - |
dc.identifier.scopus | eid_2-s2.0-41449091341 | en_HK |
dc.identifier.hkuros | 149505 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-41449091341&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 15 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 297 | en_HK |
dc.identifier.epage | 299 | en_HK |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Tung, ETK=23398349800 | en_HK |
dc.identifier.scopusauthorid | Ma, HW=23988907100 | en_HK |
dc.identifier.scopusauthorid | Cheng, C=7404797223 | en_HK |
dc.identifier.scopusauthorid | Lim, BL=7201983917 | en_HK |
dc.identifier.scopusauthorid | Wong, KB=7404759301 | en_HK |
dc.identifier.citeulike | 2465545 | - |
dc.identifier.issnl | 0929-8665 | - |