File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1309/FXNL-QTN1-94FH-AB3A
- Scopus: eid_2-s2.0-0035190559
- PMID: 11764072
- WOS: WOS:000172451700008
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma
Title | Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma |
---|---|
Authors | |
Keywords | Flk-1/KDR Flt-1 Hepatocellular carcinoma Microvessel density Vascular endothelial growth factor VEGF |
Issue Date | 2001 |
Publisher | American Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com |
Citation | American Journal Of Clinical Pathology, 2001, v. 116 n. 6, p. 838-845 How to Cite? |
Abstract | Assessment of angiogenesis may yield important information for an effective antiangiogenic treatment for hepatocellular carcinoma (HCC) because HCC is characteristically hypervascular. We examined the relationship of microvessel density (MVD), vascular endothelial growth factor (VEGF), and VEGF receptors Flt-1 and Flk-1/KDR in 50 patients with HCC and in 3 hepatoma cell lines. VEGF messenger RNA (mRNA) was overexpressed in 26 tumors (52%), and the 3 VEGF isoforms (121, 165, and 189) were present in high frequencies. Flt-1 mRNA was overexpressed in 34 tumors (68%), with levels significantly increased in HCCs compared with the nontumorous livers. Tumor Flt-1 mRNA significantly correlated with tumor VEGF mRNA levels. Within the group of tumors 8.5 cm or less in diameter, tumors with intrahepatic metastasis in the form of tumor microsatellite formation had significantly higher VEGF mRNA levels. MVD assessed by immunohistochemical analysis with CD34 antibody was inversely related to tumor size. Angiogenesis as assessed by MVD and tumor VEGF expression seems to have a more important role in tumor growth and intrahepatic metastasis in smaller HCCs. The differential up-regulation of Flt-1 suggests that it may have an important role in angiogenesis in HCC. |
Persistent Identifier | http://hdl.handle.net/10722/88657 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.775 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ng, IOL | en_HK |
dc.contributor.author | Poon, RTP | en_HK |
dc.contributor.author | Lee, JMF | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.contributor.author | Ng, M | en_HK |
dc.contributor.author | Tso, WK | en_HK |
dc.date.accessioned | 2010-09-06T09:46:15Z | - |
dc.date.available | 2010-09-06T09:46:15Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | American Journal Of Clinical Pathology, 2001, v. 116 n. 6, p. 838-845 | en_HK |
dc.identifier.issn | 0002-9173 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/88657 | - |
dc.description.abstract | Assessment of angiogenesis may yield important information for an effective antiangiogenic treatment for hepatocellular carcinoma (HCC) because HCC is characteristically hypervascular. We examined the relationship of microvessel density (MVD), vascular endothelial growth factor (VEGF), and VEGF receptors Flt-1 and Flk-1/KDR in 50 patients with HCC and in 3 hepatoma cell lines. VEGF messenger RNA (mRNA) was overexpressed in 26 tumors (52%), and the 3 VEGF isoforms (121, 165, and 189) were present in high frequencies. Flt-1 mRNA was overexpressed in 34 tumors (68%), with levels significantly increased in HCCs compared with the nontumorous livers. Tumor Flt-1 mRNA significantly correlated with tumor VEGF mRNA levels. Within the group of tumors 8.5 cm or less in diameter, tumors with intrahepatic metastasis in the form of tumor microsatellite formation had significantly higher VEGF mRNA levels. MVD assessed by immunohistochemical analysis with CD34 antibody was inversely related to tumor size. Angiogenesis as assessed by MVD and tumor VEGF expression seems to have a more important role in tumor growth and intrahepatic metastasis in smaller HCCs. The differential up-regulation of Flt-1 suggests that it may have an important role in angiogenesis in HCC. | en_HK |
dc.language | eng | en_HK |
dc.publisher | American Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com | en_HK |
dc.relation.ispartof | American Journal of Clinical Pathology | en_HK |
dc.subject | Flk-1/KDR | en_HK |
dc.subject | Flt-1 | en_HK |
dc.subject | Hepatocellular carcinoma | en_HK |
dc.subject | Microvessel density | en_HK |
dc.subject | Vascular endothelial growth factor | en_HK |
dc.subject | VEGF | en_HK |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Carcinoma, Hepatocellular - blood supply - pathology - surgery | en_HK |
dc.subject.mesh | DNA Primers | en_HK |
dc.subject.mesh | DNA, Neoplasm - analysis | en_HK |
dc.subject.mesh | Endothelial Growth Factors - genetics - metabolism | en_HK |
dc.subject.mesh | Extracellular Matrix Proteins - genetics - metabolism | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunoenzyme Techniques | en_HK |
dc.subject.mesh | Liver Neoplasms - blood supply - pathology - surgery | en_HK |
dc.subject.mesh | Lymphokines - genetics - metabolism | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Microcirculation | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Neovascularization, Pathologic - metabolism | en_HK |
dc.subject.mesh | RNA, Messenger - metabolism | en_HK |
dc.subject.mesh | Receptor Protein-Tyrosine Kinases - genetics - metabolism | en_HK |
dc.subject.mesh | Receptors, Growth Factor - genetics - metabolism | en_HK |
dc.subject.mesh | Receptors, Vascular Endothelial Growth Factor | en_HK |
dc.subject.mesh | Reverse Transcriptase Polymerase Chain Reaction | en_HK |
dc.subject.mesh | Tumor Cells, Cultured - metabolism - pathology | en_HK |
dc.subject.mesh | Vascular Endothelial Growth Factor A | en_HK |
dc.subject.mesh | Vascular Endothelial Growth Factor Receptor-1 | en_HK |
dc.subject.mesh | Vascular Endothelial Growth Factors | en_HK |
dc.title | Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9173&volume=116&spage=838&epage=845&date=2001&atitle=Microvessel+density,+vascular+endothelial+growth+factor+and+its+receptors+Flt-1+and+Flk-1/KDR+in+hepatocellular+carcinoma | en_HK |
dc.identifier.email | Ng, IOL: iolng@hkucc.hku.hk | en_HK |
dc.identifier.email | Poon, RTP: poontp@hkucc.hku.hk | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.authority | Ng, IOL=rp00335 | en_HK |
dc.identifier.authority | Poon, RTP=rp00446 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1309/FXNL-QTN1-94FH-AB3A | en_HK |
dc.identifier.pmid | 11764072 | - |
dc.identifier.scopus | eid_2-s2.0-0035190559 | en_HK |
dc.identifier.hkuros | 66023 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035190559&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 116 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 838 | en_HK |
dc.identifier.epage | 845 | en_HK |
dc.identifier.isi | WOS:000172451700008 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Ng, IOL=7102753722 | en_HK |
dc.identifier.scopusauthorid | Poon, RTP=7103097223 | en_HK |
dc.identifier.scopusauthorid | Lee, JMF=36065603500 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.scopusauthorid | Ng, M=7202076310 | en_HK |
dc.identifier.scopusauthorid | Tso, WK=7006905486 | en_HK |
dc.identifier.issnl | 0002-9173 | - |