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Article: Liver cancer stem cells: Implications for a new therapeutic target

TitleLiver cancer stem cells: Implications for a new therapeutic target
Authors
Lee, TKWCastilho, AMa, SNg, IOL
KeywordsBone marrow cells
CSCs
HCC
Hepatocytes
Oval cells
Issue Date2009
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1
Citation
Liver International, 2009, v. 29 n. 7, p. 955-965 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1478-3231.2009.02040.x
AbstractHepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells. However, the result is often dismal due to the chemoresistant nature of this tumour type. Recent research efforts on stem cells and cancer biology have shed light on new directions for the eradication of cancer stem cells (CSCs) in HCC. The liver is a distinctive organ with the ability of tissue renewal in response to injury. Based on the hypothesis that cancer development is derived from the hierarchy of the stem cell system, we will briefly discuss the origin of liver stem cells and its relation to HCC development. We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease. © 2009 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/88508
ISSN
1478-3223
2021 Impact Factor: 8.754
2020 SCImago Journal Rankings: 1.873
ISI Accession Number ID
WOS:000267709300001
Funding AgencyGrant Number
Hong Kong Research Grants Council Collaborative Research FundHKU 1/06C
Funding Information:

Financial support: This study was funded by Hong Kong Research Grants Council Collaborative Research Fund (HKU 1/06C).

References
References in Scopus
Grants
Molecular pathology of liver cancer - a multidisciplinary study

 

DC FieldValueLanguage
dc.contributor.authorLee, TKWen_HK
dc.contributor.authorCastilho, Aen_HK
dc.contributor.authorMa, Sen_HK
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2010-09-06T09:44:17Z-
dc.date.available2010-09-06T09:44:17Z-
dc.date.issued2009en_HK
dc.identifier.citationLiver International, 2009, v. 29 n. 7, p. 955-965en_HK
dc.identifier.issn1478-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88508-
dc.description.abstractHepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells. However, the result is often dismal due to the chemoresistant nature of this tumour type. Recent research efforts on stem cells and cancer biology have shed light on new directions for the eradication of cancer stem cells (CSCs) in HCC. The liver is a distinctive organ with the ability of tissue renewal in response to injury. Based on the hypothesis that cancer development is derived from the hierarchy of the stem cell system, we will briefly discuss the origin of liver stem cells and its relation to HCC development. We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease. © 2009 John Wiley & Sons A/S.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1en_HK
dc.relation.ispartofLiver Internationalen_HK
dc.subjectBone marrow cells-
dc.subjectCSCs-
dc.subjectHCC-
dc.subjectHepatocytes-
dc.subjectOval cells-
dc.subject.meshAnimalsen_HK
dc.subject.meshAntineoplastic Agents - therapeutic useen_HK
dc.subject.meshCarcinoma, Hepatocellular - drug therapy - metabolism - pathologyen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshDrug Designen_HK
dc.subject.meshHepatocytes - drug effects - metabolism - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver - drug effects - metabolism - pathologyen_HK
dc.subject.meshLiver Neoplasms - drug therapy - metabolism - pathologyen_HK
dc.subject.meshLiver Regenerationen_HK
dc.subject.meshNeoplastic Stem Cells - drug effects - metabolism - pathologyen_HK
dc.subject.meshSignal Transductionen_HK
dc.subject.meshStem Cells - drug effects - metabolism - pathologyen_HK
dc.subject.meshTumor Markers, Biological - metabolismen_HK
dc.titleLiver cancer stem cells: Implications for a new therapeutic targeten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1478-3223&volume=29&spage=955&epage=965&date=2009&atitle=Liver+cancer+stem+cells:+Implications+for+a+new+therapeutic+targeten_HK
dc.identifier.emailLee, TKW:tkwlee@hkucc.hku.hken_HK
dc.identifier.emailMa, S:sma@pathology.hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.authorityLee, TKW=rp00447en_HK
dc.identifier.authorityMa, S=rp00506en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1478-3231.2009.02040.xen_HK
dc.identifier.pmid19490415-
dc.identifier.scopuseid_2-s2.0-67650469849en_HK
dc.identifier.hkuros158604en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650469849&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue7en_HK
dc.identifier.spage955en_HK
dc.identifier.epage965en_HK
dc.identifier.isiWOS:000267709300001-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectMolecular pathology of liver cancer - a multidisciplinary study-
dc.identifier.citeulike5110192-
dc.identifier.issnl1478-3223-

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