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Article: Molecular pathogenesis of hepatocellular carcinoma

TitleMolecular pathogenesis of hepatocellular carcinoma
Authors
KeywordsCell signalling pathways
Epigenetic
Genetic alterations
Hepatocellular carcinoma
Molecular pathogenesis
Issue Date2008
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1
Citation
Liver International, 2008, v. 28 n. 2, p. 160-174 How to Cite?
AbstractHepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death worldwide. Hepatocarcinogenesis is a multistep process evolving from normal through chronic hepatitis/ cirrhosis and dysplastic nodules to HCC. With advances in molecular methods, there is a growing understanding of the molecular mechanisms in hepatocarcinogenesis. Hepatocarcinogenesis is strongly linked to increases in allelic losses, chromosomal changes, gene mutations, epigenetic alterations and alterations in molecular cellular pathways. Some of these alterations are accompanied by a stepwise increase in the different pathological disease stages in hepatocarcinogenesis. Overall, a detailed understanding of the underlying molecular mechanisms involved in the progression of HCC is of fundamental importance to the development of effective prevention and treatment regimes for HCC. © 2007 The Authors. Journal compilation © 2007 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/88374
ISSN
2023 Impact Factor: 6.0
2023 SCImago Journal Rankings: 2.087
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, CMen_HK
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2010-09-06T09:42:32Z-
dc.date.available2010-09-06T09:42:32Z-
dc.date.issued2008en_HK
dc.identifier.citationLiver International, 2008, v. 28 n. 2, p. 160-174en_HK
dc.identifier.issn1478-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88374-
dc.description.abstractHepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death worldwide. Hepatocarcinogenesis is a multistep process evolving from normal through chronic hepatitis/ cirrhosis and dysplastic nodules to HCC. With advances in molecular methods, there is a growing understanding of the molecular mechanisms in hepatocarcinogenesis. Hepatocarcinogenesis is strongly linked to increases in allelic losses, chromosomal changes, gene mutations, epigenetic alterations and alterations in molecular cellular pathways. Some of these alterations are accompanied by a stepwise increase in the different pathological disease stages in hepatocarcinogenesis. Overall, a detailed understanding of the underlying molecular mechanisms involved in the progression of HCC is of fundamental importance to the development of effective prevention and treatment regimes for HCC. © 2007 The Authors. Journal compilation © 2007 Blackwell Munksgaard.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1en_HK
dc.relation.ispartofLiver Internationalen_HK
dc.subjectCell signalling pathways-
dc.subjectEpigenetic-
dc.subjectGenetic alterations-
dc.subjectHepatocellular carcinoma-
dc.subjectMolecular pathogenesis-
dc.subject.meshCarcinoma, Hepatocellular - geneticsen_HK
dc.subject.meshChromosomal Instability - geneticsen_HK
dc.subject.meshEpigenesis, Genetic - geneticsen_HK
dc.subject.meshGene Expression Regulation, Neoplastic - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLoss of Heterozygosityen_HK
dc.subject.meshMutation - geneticsen_HK
dc.subject.meshSignal Transduction - geneticsen_HK
dc.subject.meshWnt Proteins - metabolismen_HK
dc.subject.meshbeta Catenin - metabolismen_HK
dc.subject.meshras Proteins - metabolismen_HK
dc.titleMolecular pathogenesis of hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1478-3223&volume=28 &issue=2&spage=160&epage=174&date=2008&atitle=Molecular+pathogenesis+of+hepatocellular+carcinomaen_HK
dc.identifier.emailWong, CM:jackwong@pathology.hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.authorityWong, CM=rp00231en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1478-3231.2007.01637.xen_HK
dc.identifier.pmid18069974-
dc.identifier.scopuseid_2-s2.0-38849119717en_HK
dc.identifier.hkuros146899en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38849119717&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue2en_HK
dc.identifier.spage160en_HK
dc.identifier.epage174en_HK
dc.identifier.isiWOS:000252813200004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.citeulike2321400-
dc.identifier.issnl1478-3223-

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