File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1097/00000478-199603000-00008
- Scopus: eid_2-s2.0-0030029985
- PMID: 8772785
- WOS: WOS:A1996TX84300008
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Follicular Dendritic Cell Tumor of the Liver: Evidence for an Epstein-Barr Virus-related Clonal Proliferation of Follicular Dendritic Cells
Title | Follicular Dendritic Cell Tumor of the Liver: Evidence for an Epstein-Barr Virus-related Clonal Proliferation of Follicular Dendritic Cells |
---|---|
Authors | |
Keywords | Clonal EBV Clonal tumor Epstein-barr virus Follicular dendritic cell Follicular dendritic cell tumor In situ hybridization Liver Ultrastructure |
Issue Date | 1996 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com |
Citation | American Journal Of Surgical Pathology, 1996, v. 20 n. 3, p. 313-324 How to Cite? |
Abstract | Tumors of the follicular dendritic cell are uncommon, and most occur as primary lymph node tumors. We report a case of primary follicular dendritic cell tumor of the liver that was initially reported as an inflammatory pseudotumor. The neoplasm recurred as two separate tumor masses 30 months after complete resection of the hepatic inflammatory pseudotumor. It showed a wide spectrum of morphologic features ranging from areas with fascicles of very bland spindle cells amidst a background population of lymphocytes, reminiscent of inflammatory pseudotumor, to areas of dispersed sheets of highly pleomorphic tumor cells with a relative paucity of reactive inflammatory cells. The diagnosis was confirmed by positive immunohistochemical staining with CD21, CD35, R4/23, and Ki-M4 and by ultrastructural demonstration of convoluted interdigitating cell processes joined by desmosomes. The background lymphocytes were oligoclonal, CD8-positive T cells. In situ hybridization for Epstein-Barr virus (EBV)-encoded RNA was positive in the tumor cells in the original and recurrent tumors. More importantly, the cells showed identical episomal clonal EBV on Southern blot analysis, implying that the initial and recurrent tumors are due to clonal proliferation of EBV-positive neoplastic follicular dendritic cells. The tumor cells expressed latent membrane protein but not EBV-encoded nuclear antigen 2 (EBNA2) or ZEBRA. Such gene expression is very similar to that of Hodgkin's disease and nasopharyngeal carcinoma. The strong expression of latent membrane protein restricted to the tumor cells and the clonality of the EBV suggest that the virus may be involved in the pathogenesis of this tumor and not present merely as a bystander.. |
Persistent Identifier | http://hdl.handle.net/10722/88361 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.723 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shek, TWH | en_HK |
dc.contributor.author | Ho, FCS | en_HK |
dc.contributor.author | Ng, IOL | en_HK |
dc.contributor.author | Chan, ACL | en_HK |
dc.contributor.author | Ma, L | en_HK |
dc.contributor.author | Srivastava, G | en_HK |
dc.date.accessioned | 2010-09-06T09:42:22Z | - |
dc.date.available | 2010-09-06T09:42:22Z | - |
dc.date.issued | 1996 | en_HK |
dc.identifier.citation | American Journal Of Surgical Pathology, 1996, v. 20 n. 3, p. 313-324 | en_HK |
dc.identifier.issn | 0147-5185 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/88361 | - |
dc.description.abstract | Tumors of the follicular dendritic cell are uncommon, and most occur as primary lymph node tumors. We report a case of primary follicular dendritic cell tumor of the liver that was initially reported as an inflammatory pseudotumor. The neoplasm recurred as two separate tumor masses 30 months after complete resection of the hepatic inflammatory pseudotumor. It showed a wide spectrum of morphologic features ranging from areas with fascicles of very bland spindle cells amidst a background population of lymphocytes, reminiscent of inflammatory pseudotumor, to areas of dispersed sheets of highly pleomorphic tumor cells with a relative paucity of reactive inflammatory cells. The diagnosis was confirmed by positive immunohistochemical staining with CD21, CD35, R4/23, and Ki-M4 and by ultrastructural demonstration of convoluted interdigitating cell processes joined by desmosomes. The background lymphocytes were oligoclonal, CD8-positive T cells. In situ hybridization for Epstein-Barr virus (EBV)-encoded RNA was positive in the tumor cells in the original and recurrent tumors. More importantly, the cells showed identical episomal clonal EBV on Southern blot analysis, implying that the initial and recurrent tumors are due to clonal proliferation of EBV-positive neoplastic follicular dendritic cells. The tumor cells expressed latent membrane protein but not EBV-encoded nuclear antigen 2 (EBNA2) or ZEBRA. Such gene expression is very similar to that of Hodgkin's disease and nasopharyngeal carcinoma. The strong expression of latent membrane protein restricted to the tumor cells and the clonality of the EBV suggest that the virus may be involved in the pathogenesis of this tumor and not present merely as a bystander.. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com | en_HK |
dc.relation.ispartof | American Journal of Surgical Pathology | en_HK |
dc.rights | American Journal of Surgical Pathology. Copyright © Lippincott Williams & Wilkins. | en_HK |
dc.subject | Clonal EBV | - |
dc.subject | Clonal tumor | - |
dc.subject | Epstein-barr virus | - |
dc.subject | Follicular dendritic cell | - |
dc.subject | Follicular dendritic cell tumor | - |
dc.subject | In situ hybridization | - |
dc.subject | Liver | - |
dc.subject | Ultrastructure | - |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Cell Division - physiology | en_HK |
dc.subject.mesh | Cell Line | en_HK |
dc.subject.mesh | Dendritic Cells - pathology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Gene Expression | en_HK |
dc.subject.mesh | Gene Rearrangement | en_HK |
dc.subject.mesh | Herpesvirus 4, Human - genetics - isolation & purification - physiology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | Liver Neoplasms - metabolism - pathology - virology | en_HK |
dc.subject.mesh | Receptors, Antigen, T-Cell - genetics | en_HK |
dc.title | Follicular Dendritic Cell Tumor of the Liver: Evidence for an Epstein-Barr Virus-related Clonal Proliferation of Follicular Dendritic Cells | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0147-5185&volume=20&issue=3&spage=313&epage=324&date=1996&atitle=Follicular+dendritic+cell+tumor+of+the+liver:+evidence+for+an+Epstein-Barr+virus-related+clonal+proliferation+of+follicular+dendritic+cells | en_HK |
dc.identifier.email | Ng, IOL:iolng@hkucc.hku.hk | en_HK |
dc.identifier.email | Srivastava, G:gopesh@pathology.hku.hk | en_HK |
dc.identifier.authority | Ng, IOL=rp00335 | en_HK |
dc.identifier.authority | Srivastava, G=rp00365 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/00000478-199603000-00008 | - |
dc.identifier.pmid | 8772785 | - |
dc.identifier.scopus | eid_2-s2.0-0030029985 | en_HK |
dc.identifier.hkuros | 14061 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030029985&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 20 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 313 | en_HK |
dc.identifier.epage | 324 | en_HK |
dc.identifier.isi | WOS:A1996TX84300008 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.issnl | 0147-5185 | - |