File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Onset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early life

TitleOnset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early life
Authors
Issue Date2001
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/
Citation
Pediatric Research, 2001, v. 50 n. 6, p. 737-742 How to Cite?
AbstractForty-eight normal full-term Chinese babies (25 boys and 23 girls) were followed up every 2 mo in the first year and every 3 mo during the second year of life for anthropometric measurements. Blood samples were taken at birth and at 6, 10, 12, and 18 mo after birth for serum GH-binding protein, IGF-I, and IGF-binding protein 3 analysis. Onset of the childhood phase of growth in the infants was determined from the growth data plotted on Infancy-Childhood-Puberty growth charts. The serum GH-binding protein concentrations were low in cord blood but rose significantly at 6 mo, with slower rises in late infancy and early childhood. However, a significant rise in serum IGF-I and IGF-binding protein 3 levels was only observed from 10 mo of life onward. The change in IGF-I between birth and 6 mo was significantly correlated with length gain (r 2 = 0.35, p < 0.05) and body mass index gain (r 2 = 0.41, p < 0.01) during the same period. The 34 infants with onset of childhood phase of growth between 6 and 10 mo had a higher mean serum IGF-I value at 10 mo (8.8 ± 5.8 nM versus 4.9 ± 3.1 nM; p < 0.05) and higher length velocity between 10 and 12 mo (16.3 ± 4.7 cm/y versus 8.8 ± 4.3 cm/y; p < 0.001) compared with the 14 infants with a later onset after 10 mo of age. A significant correlation between a change in serum IGF-I and IGF-binding protein 3 levels was observed during the three 6-mo periods between birth and 18 mo, but a significant correlation between a change in serum GH-binding protein and a change in serum IGF-I or IGF-binding protein 3 levels was only seen between 12 and 18 mo of age. The multiple regression analysis (r 2 = 0.43, p = 0.0002) revealed that the change in serum GH-binding protein and IGF-I concentrations between 6 and 12 mo of age and the age of onset of childhood phase of growth could explain 43% of the length gain between 6 and 12 mo of age in our babies. The results of our study support the hypothesis that the onset of the childhood phase of growth is associated with the onset of significant GH action on growth.
Persistent Identifierhttp://hdl.handle.net/10722/87625
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.184
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLow, LCKen_HK
dc.contributor.authorTam, SYMen_HK
dc.contributor.authorKwan, EYWen_HK
dc.contributor.authorTsang, AMCen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.date.accessioned2010-09-06T09:32:15Z-
dc.date.available2010-09-06T09:32:15Z-
dc.date.issued2001en_HK
dc.identifier.citationPediatric Research, 2001, v. 50 n. 6, p. 737-742en_HK
dc.identifier.issn0031-3998en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87625-
dc.description.abstractForty-eight normal full-term Chinese babies (25 boys and 23 girls) were followed up every 2 mo in the first year and every 3 mo during the second year of life for anthropometric measurements. Blood samples were taken at birth and at 6, 10, 12, and 18 mo after birth for serum GH-binding protein, IGF-I, and IGF-binding protein 3 analysis. Onset of the childhood phase of growth in the infants was determined from the growth data plotted on Infancy-Childhood-Puberty growth charts. The serum GH-binding protein concentrations were low in cord blood but rose significantly at 6 mo, with slower rises in late infancy and early childhood. However, a significant rise in serum IGF-I and IGF-binding protein 3 levels was only observed from 10 mo of life onward. The change in IGF-I between birth and 6 mo was significantly correlated with length gain (r 2 = 0.35, p < 0.05) and body mass index gain (r 2 = 0.41, p < 0.01) during the same period. The 34 infants with onset of childhood phase of growth between 6 and 10 mo had a higher mean serum IGF-I value at 10 mo (8.8 ± 5.8 nM versus 4.9 ± 3.1 nM; p < 0.05) and higher length velocity between 10 and 12 mo (16.3 ± 4.7 cm/y versus 8.8 ± 4.3 cm/y; p < 0.001) compared with the 14 infants with a later onset after 10 mo of age. A significant correlation between a change in serum IGF-I and IGF-binding protein 3 levels was observed during the three 6-mo periods between birth and 18 mo, but a significant correlation between a change in serum GH-binding protein and a change in serum IGF-I or IGF-binding protein 3 levels was only seen between 12 and 18 mo of age. The multiple regression analysis (r 2 = 0.43, p = 0.0002) revealed that the change in serum GH-binding protein and IGF-I concentrations between 6 and 12 mo of age and the age of onset of childhood phase of growth could explain 43% of the length gain between 6 and 12 mo of age in our babies. The results of our study support the hypothesis that the onset of the childhood phase of growth is associated with the onset of significant GH action on growth.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/en_HK
dc.relation.ispartofPediatric Researchen_HK
dc.rightsPediatric Research. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAgingen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshCarrier Proteins - blooden_HK
dc.subject.meshChinaen_HK
dc.subject.meshFetal Blood - chemistryen_HK
dc.subject.meshGrowth - physiologyen_HK
dc.subject.meshHuman Growth Hormone - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfant, Newborn - physiologyen_HK
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3 - blooden_HK
dc.subject.meshInsulin-Like Growth Factor I - metabolismen_HK
dc.subject.meshLongitudinal Studiesen_HK
dc.subject.meshTime Factorsen_HK
dc.titleOnset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early lifeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0031-3998&volume=50&issue=6&spage=737&epage=742&date=2001&atitle=Onset+of+Significant+GH+Dependence+of+Serum+IGF-I+and+IGF-Binding+Protein+3+Concentrations+in+Early+Lifeen_HK
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hken_HK
dc.identifier.emailTam, SYM: ymstam@hku.hken_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityLow, LCK=rp00337en_HK
dc.identifier.authorityTam, SYM=rp00407en_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1203/00006450-200112000-00018-
dc.identifier.pmid11726733-
dc.identifier.scopuseid_2-s2.0-0035199299en_HK
dc.identifier.hkuros64938en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035199299&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue6en_HK
dc.identifier.spage737en_HK
dc.identifier.epage742en_HK
dc.identifier.isiWOS:000172398500017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLow, LCK=7007049461en_HK
dc.identifier.scopusauthoridTam, SYM=18937399200en_HK
dc.identifier.scopusauthoridKwan, EYW=55222528300en_HK
dc.identifier.scopusauthoridTsang, AMC=7006979236en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.issnl0031-3998-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats