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- Publisher Website: 10.1093/humrep/15.5.1159
- Scopus: eid_2-s2.0-0034057654
- PMID: 10783370
- WOS: WOS:000086843700034
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Article: Vaginal misoprostol alone for medical abortion up to 9 weeks of gestation: Efficacy and acceptability
Title | Vaginal misoprostol alone for medical abortion up to 9 weeks of gestation: Efficacy and acceptability |
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Authors | |
Keywords | Abortion Medical Misoprostol |
Issue Date | 2000 |
Publisher | Oxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/ |
Citation | Human Reproduction, 2000, v. 15 n. 5, p. 1159-1162 How to Cite? |
Abstract | Misoprostol and mifepristone have been shown to be effective for medical abortion up to 9 weeks of gestation. When used alone, the successful complete abortion rate dropped to ~60%. It has been demonstrated that by adding water to misoprostol, the success rate rose to 92%. This is the first randomized study to investigate the efficacy of misoprostol and water versus misoprostol alone for first trimester medical abortion in women at ≤ 9 weeks of gestation. Eighty women were randomly assigned to group 1 (water added to misoprostol) and group 2 (misoprostol alone). Vaginal misoprostol 800 μg was given on days 1, 3 and 5. If the woman did not require vacuum aspiration during the period up to the return of first menstruation after medical abortion, the outcome was classified as complete abortion. The incidence of side-effects and the acceptability were assessed through a standardized questionnaire during and after the abortion. The complete abortion rate appeared higher when water was added but the difference did not reach statistical significance. Gastrointestinal side-effects were common but well tolerated in both groups. Overall, 40% of the women preferred a surgical method in the future because of the high failure rate. With an overall complete abortion rate of 85%, it is probably not a clinically acceptable method even if the addition of water can improve the results. We conclude that the addition of water onto misoprostol tablets does not improve its efficacy in first trimester medical abortion. Misoprostol alone is not recommended for medical abortion (up to 9 weeks of pregnancy) because of the high failure rate and low acceptability. |
Persistent Identifier | http://hdl.handle.net/10722/87162 |
ISSN | 2023 Impact Factor: 6.0 2023 SCImago Journal Rankings: 1.852 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ngai, SW | en_HK |
dc.contributor.author | Tang, OS | en_HK |
dc.contributor.author | Chan, YM | en_HK |
dc.contributor.author | Ho, PC | en_HK |
dc.date.accessioned | 2010-09-06T09:26:08Z | - |
dc.date.available | 2010-09-06T09:26:08Z | - |
dc.date.issued | 2000 | en_HK |
dc.identifier.citation | Human Reproduction, 2000, v. 15 n. 5, p. 1159-1162 | en_HK |
dc.identifier.issn | 0268-1161 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/87162 | - |
dc.description.abstract | Misoprostol and mifepristone have been shown to be effective for medical abortion up to 9 weeks of gestation. When used alone, the successful complete abortion rate dropped to ~60%. It has been demonstrated that by adding water to misoprostol, the success rate rose to 92%. This is the first randomized study to investigate the efficacy of misoprostol and water versus misoprostol alone for first trimester medical abortion in women at ≤ 9 weeks of gestation. Eighty women were randomly assigned to group 1 (water added to misoprostol) and group 2 (misoprostol alone). Vaginal misoprostol 800 μg was given on days 1, 3 and 5. If the woman did not require vacuum aspiration during the period up to the return of first menstruation after medical abortion, the outcome was classified as complete abortion. The incidence of side-effects and the acceptability were assessed through a standardized questionnaire during and after the abortion. The complete abortion rate appeared higher when water was added but the difference did not reach statistical significance. Gastrointestinal side-effects were common but well tolerated in both groups. Overall, 40% of the women preferred a surgical method in the future because of the high failure rate. With an overall complete abortion rate of 85%, it is probably not a clinically acceptable method even if the addition of water can improve the results. We conclude that the addition of water onto misoprostol tablets does not improve its efficacy in first trimester medical abortion. Misoprostol alone is not recommended for medical abortion (up to 9 weeks of pregnancy) because of the high failure rate and low acceptability. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Oxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/ | en_HK |
dc.relation.ispartof | Human Reproduction | en_HK |
dc.rights | Human Reproduction. Copyright © Oxford University Press. | en_HK |
dc.subject | Abortion | en_HK |
dc.subject | Medical | en_HK |
dc.subject | Misoprostol | en_HK |
dc.title | Vaginal misoprostol alone for medical abortion up to 9 weeks of gestation: Efficacy and acceptability | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=15&issue=5&spage=1159&epage=1162&date=2000&atitle=Vaginal+misoprostol+alone+for+medical+abortion+up+to+9+weeks+of+gestation:+efficacy+and+acceptability | en_HK |
dc.identifier.email | Ho, PC:pcho@hku.hk | en_HK |
dc.identifier.authority | Ho, PC=rp00325 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/humrep/15.5.1159 | - |
dc.identifier.pmid | 10783370 | - |
dc.identifier.scopus | eid_2-s2.0-0034057654 | en_HK |
dc.identifier.hkuros | 49577 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034057654&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 15 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 1159 | en_HK |
dc.identifier.epage | 1162 | en_HK |
dc.identifier.isi | WOS:000086843700034 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Ngai, SW=7006074214 | en_HK |
dc.identifier.scopusauthorid | Tang, OS=7006723402 | en_HK |
dc.identifier.scopusauthorid | Chan, YM=7403676661 | en_HK |
dc.identifier.scopusauthorid | Ho, PC=7402211440 | en_HK |
dc.identifier.issnl | 0268-1161 | - |