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Article: Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

TitleSignificance of CD90+ Cancer Stem Cells in Human Liver Cancer
Authors
Yang, ZFHo, DWNg, MNLau, CKYu, WCNgai, PChu, PWKLam, CTPoon, RTPFan, ST
KeywordsCELLCYCLE
STEMCELL
Issue Date2008
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/ccell
Citation
Cancer Cell, 2008, v. 13 n. 2, p. 153-166 How to Cite?
DOI: http://dx.doi.org/10.1016/j.ccr.2008.01.013
AbstractThis study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90- cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45-CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44- counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90+ cells. Differential gene expression profiles were identified in the CD45-CD90+ and CD45-CD90- cells isolated from tissue and blood samples from liver cancer patients and controls. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84403
ISSN
1535-6108
2021 Impact Factor: 38.585
2020 SCImago Journal Rankings: 13.035
ISI Accession Number ID
WOS:000253026200010
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorYang, ZFen_HK
dc.contributor.authorHo, DWen_HK
dc.contributor.authorNg, MNen_HK
dc.contributor.authorLau, CKen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorNgai, Pen_HK
dc.contributor.authorChu, PWKen_HK
dc.contributor.authorLam, CTen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:52:32Z-
dc.date.available2010-09-06T08:52:32Z-
dc.date.issued2008en_HK
dc.identifier.citationCancer Cell, 2008, v. 13 n. 2, p. 153-166en_HK
dc.identifier.issn1535-6108en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84403-
dc.description.abstractThis study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90- cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45-CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44- counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90+ cells. Differential gene expression profiles were identified in the CD45-CD90+ and CD45-CD90- cells isolated from tissue and blood samples from liver cancer patients and controls. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/ccellen_HK
dc.relation.ispartofCancer Cellen_HK
dc.subjectCELLCYCLEen_HK
dc.subjectSTEMCELLen_HK
dc.titleSignificance of CD90+ Cancer Stem Cells in Human Liver Canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1535-6108&volume=13&issue=2&spage=153&epage=166&date=2008&atitle=Significance+of+CD90++cancer+stem+cells+in+human+liver+canceren_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.ccr.2008.01.013en_HK
dc.identifier.pmid18242515-
dc.identifier.scopuseid_2-s2.0-38549139140en_HK
dc.identifier.hkuros140749en_HK
dc.identifier.hkuros166238-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38549139140&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue2en_HK
dc.identifier.spage153en_HK
dc.identifier.epage166en_HK
dc.identifier.eissn1878-3686-
dc.identifier.isiWOS:000253026200010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, ZF=14018809600en_HK
dc.identifier.scopusauthoridHo, DW=7402971906en_HK
dc.identifier.scopusauthoridNg, MN=23478329500en_HK
dc.identifier.scopusauthoridLau, CK=7401968442en_HK
dc.identifier.scopusauthoridYu, WC=37022285400en_HK
dc.identifier.scopusauthoridNgai, P=23477971900en_HK
dc.identifier.scopusauthoridChu, PWK=7402159518en_HK
dc.identifier.scopusauthoridLam, CT=7402989860en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.issnl1535-6108-

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