File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.2174/092986609788167761
- Scopus: eid_2-s2.0-67649385970
- PMID: 19442233
- WOS: WOS:000265799400012
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Endotoxin-neutralizing peptides as gram-negative sepsis therapeutics
Title | Endotoxin-neutralizing peptides as gram-negative sepsis therapeutics |
---|---|
Authors | |
Keywords | Anti-microbial peptide BPIP CD18 Endotoxin-neutralizing peptide Gram-negative sepsis |
Issue Date | 2009 |
Publisher | Bentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ppl/index.htm |
Citation | Protein And Peptide Letters, 2009, v. 16 n. 5, p. 539-542 How to Cite? |
Abstract | Bacterial endotoxin [e.g. lipopolysaccharide (LPS)] can trigger systemic hyper-inflammatory that subsequently leads to multiple organ failure and lethality (gram-negative sepsis). This paper describes the development of endotoxin- neutralizing peptides that potentially treat sepsis. These peptides have been derived from bactericidal/permeability- increasing protein (BPIP), anti-microbial peptides, and leukocyte CD18 antigen and some of these peptides have been tested in clinical studies. © 2009 Bentham Science Publishers Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/84381 |
ISSN | 2023 Impact Factor: 1.0 2023 SCImago Journal Rankings: 0.349 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, KF | en_HK |
dc.contributor.author | Luk, JM | en_HK |
dc.date.accessioned | 2010-09-06T08:52:16Z | - |
dc.date.available | 2010-09-06T08:52:16Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Protein And Peptide Letters, 2009, v. 16 n. 5, p. 539-542 | en_HK |
dc.identifier.issn | 0929-8665 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/84381 | - |
dc.description.abstract | Bacterial endotoxin [e.g. lipopolysaccharide (LPS)] can trigger systemic hyper-inflammatory that subsequently leads to multiple organ failure and lethality (gram-negative sepsis). This paper describes the development of endotoxin- neutralizing peptides that potentially treat sepsis. These peptides have been derived from bactericidal/permeability- increasing protein (BPIP), anti-microbial peptides, and leukocyte CD18 antigen and some of these peptides have been tested in clinical studies. © 2009 Bentham Science Publishers Ltd. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Bentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ppl/index.htm | en_HK |
dc.relation.ispartof | Protein and Peptide Letters | en_HK |
dc.subject | Anti-microbial peptide | en_HK |
dc.subject | BPIP | en_HK |
dc.subject | CD18 | en_HK |
dc.subject | Endotoxin-neutralizing peptide | en_HK |
dc.subject | Gram-negative sepsis | en_HK |
dc.subject.mesh | Amino Acid Sequence | - |
dc.subject.mesh | Endotoxins - antagonists and inhibitors - metabolism | - |
dc.subject.mesh | Gram-Negative Bacteria - drug effects - physiology | - |
dc.subject.mesh | Peptides - chemistry - metabolism - pharmacology - therapeutic use | - |
dc.subject.mesh | Sepsis - drug therapy | - |
dc.title | Endotoxin-neutralizing peptides as gram-negative sepsis therapeutics | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0929-8665&volume=16&issue=5&spage=539&epage=542&date=2009&atitle=Endotoxin-neutralizing+peptides+as+gram-negative+sepsis+therapeutics | en_HK |
dc.identifier.email | Luk, JM: jmluk@hkucc.hku.hk | en_HK |
dc.identifier.authority | Luk, JM=rp00349 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2174/092986609788167761 | en_HK |
dc.identifier.pmid | 19442233 | - |
dc.identifier.scopus | eid_2-s2.0-67649385970 | en_HK |
dc.identifier.hkuros | 168581 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67649385970&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 16 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 539 | en_HK |
dc.identifier.epage | 542 | en_HK |
dc.identifier.isi | WOS:000265799400012 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Wong, KF=35081410800 | en_HK |
dc.identifier.scopusauthorid | Luk, JM=7006777791 | en_HK |
dc.identifier.citeulike | 4447208 | - |
dc.identifier.issnl | 0929-8665 | - |