IHPBA concordant classification of primary liver cancer: Working group report

Abstract

The working group of the International Scientific Committee of the International Hepato-Pancreato-Biliary Association (IHPBA) examined conventional staging systems and decided to establish a new staging system that depended on macroscopic findings after liver resection. The TNM/International Union Against Cancer (UICC) classification has been widely used but is too complicated. Vauthey and colleagues, and the Liver Cancer Study Group of Japan (LCSGJ) have proposed new simplified classifications. These are compared and discussed. The IHPBA working group proposed a new classification, as follows. T factor: 1. Solitary 2. No more than 2 cm 3. No vascular invasion to portal vein, hepatic vein, and bile duct T1 meets all of the above three requirements. T2 meets two of the three requirements. T3 meets one of the three requirements. T4 does not meet any requirements. Stage: I T1N0M0 II T2N0M0 III T3N0M0 IV A T4N0M0 Any TN1M0 IV B Any T/N, M1 The survival curves of each stage were separated clearly (P < 0.0001). The staging system is easy to remember and easy to use. We hope this staging system will be generally used in future.