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Article: Elasticity of small artery in patient with spontaneous rupture of hepatocellular carcinoma

TitleElasticity of small artery in patient with spontaneous rupture of hepatocellular carcinoma
Authors
KeywordsElastase
Elastin
Hepatocellular carcinoma
Rupture
Issue Date2004
PublisherBlackwell Publishing Ltd.
Citation
Hepatology Research, 2004, v. 29 n. 1, p. 13-17 How to Cite?
AbstractObjective: Spontaneous rupture of hepatocellular carcinoma (HCC) is common in Asia and Africa with unclear mechanism. In our previous study, we found that the vascular injury was related to the HCC rupture. In this study, the structure of elastin around the small artery was deeply investigated to confirm our previous study. Methods: Immunohistochemical technique and transmission electron microscopy were used to study 23 specimens from ruptured HCC and 30 cases with nonruptured HCC. Results: The layer of elastin around the vascular wall was significant thicker in patients with ruptured HCC than that in nonruptured HCC. The proliferation of elastin, abnormal distribution of neutrophil elastase and degradation of collagen fibril were predominantly present in the specimens from ruptured HCC. The phenomenon that the infiltrated neutrophils from bloodstream into the vascular wall, which caused the vascular injury, can be found in specimens from ruptured HCC. The vascular injury mainly occurred in small artery. Since the damaged vessels could become stiff and weak, which would be more prone to splitting and result in hemorrhage in patients with ruptured HCC, we postulated that the vascular injury, especially the inelastic small artery, may relate the ruptured HCC. Conclusion: The vascular injury in small artery might relate to ruptured HCC. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/84016
ISSN
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 1.241
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, LXen_HK
dc.contributor.authorMeng, XLen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T08:47:55Z-
dc.date.available2010-09-06T08:47:55Z-
dc.date.issued2004en_HK
dc.identifier.citationHepatology Research, 2004, v. 29 n. 1, p. 13-17en_HK
dc.identifier.issn1386-6346en_HK
dc.identifier.urihttp://hdl.handle.net/10722/84016-
dc.description.abstractObjective: Spontaneous rupture of hepatocellular carcinoma (HCC) is common in Asia and Africa with unclear mechanism. In our previous study, we found that the vascular injury was related to the HCC rupture. In this study, the structure of elastin around the small artery was deeply investigated to confirm our previous study. Methods: Immunohistochemical technique and transmission electron microscopy were used to study 23 specimens from ruptured HCC and 30 cases with nonruptured HCC. Results: The layer of elastin around the vascular wall was significant thicker in patients with ruptured HCC than that in nonruptured HCC. The proliferation of elastin, abnormal distribution of neutrophil elastase and degradation of collagen fibril were predominantly present in the specimens from ruptured HCC. The phenomenon that the infiltrated neutrophils from bloodstream into the vascular wall, which caused the vascular injury, can be found in specimens from ruptured HCC. The vascular injury mainly occurred in small artery. Since the damaged vessels could become stiff and weak, which would be more prone to splitting and result in hemorrhage in patients with ruptured HCC, we postulated that the vascular injury, especially the inelastic small artery, may relate the ruptured HCC. Conclusion: The vascular injury in small artery might relate to ruptured HCC. © 2004 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd.en_HK
dc.relation.ispartofHepatology Researchen_HK
dc.rightsHepatology Research. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectElastaseen_HK
dc.subjectElastinen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectRuptureen_HK
dc.titleElasticity of small artery in patient with spontaneous rupture of hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1386-6346&volume=29&issue=1&spage=13&epage=17&date=2004&atitle=Elasticity+of+small+artery+in+patient+with+spontaneous+rupture+of+hepatocellular+carcinomaen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.hepres.2004.01.001en_HK
dc.identifier.scopuseid_2-s2.0-2342538960en_HK
dc.identifier.hkuros87751en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2342538960&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue1en_HK
dc.identifier.spage13en_HK
dc.identifier.epage17en_HK
dc.identifier.isiWOS:000222205500003-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridZhu, LX=36248128300en_HK
dc.identifier.scopusauthoridMeng, XL=7401629654en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.issnl1386-6346-

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