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- Publisher Website: 10.1038/bjc.1998.277
- Scopus: eid_2-s2.0-0031981251
- PMID: 9635849
- WOS: WOS:000073858900024
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Article: Comparison of antiemetic efficacy of granisetron and ondansetron in Oriental patients: A randomized crossover study
Title | Comparison of antiemetic efficacy of granisetron and ondansetron in Oriental patients: A randomized crossover study |
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Authors | |
Keywords | Chemotherapy Chinese Granisetron Nausea Ondansetron Vomiting |
Issue Date | 1998 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc |
Citation | British Journal Of Cancer, 1998, v. 77 n. 10, p. 1683-1685 How to Cite? |
Abstract | A double-blind randomized crossover trial was performed to compare the antiemetic efficacy of two 5-HT3 receptor antagonists, granisetron and ondansetron, in Chinese patients receiving adjuvant chemotherapy (cyclophosphamide, methotrexate and 5-fluorouracil) for breast cancer. Twenty patients were randomized to receive chemotherapy with either granisetron on day 1 and ondansetron on day 8 of the first cycle followed by the reverse order in the second cycle, or vice versa. The number of vomiting episodes and the severity of nausea in the first 24 h (acute vomiting/nausea) and the following 7 days (delayed vomiting/nausea) were studied. Acute vomiting was completely prevented in 29 (72.5%) cycles with granisetron and 27 (67.5%) cycles with ondansetron, and treatment failure (> 5 vomiting episodes) occurred in two (5%) cycles with each agent (P = NS). Acute nausea was completely controlled in 15 (37.5%) cycles with granisetron and 14 (35%) cycles with ondansetron, whereas severe acute nausea occurred in four (10%) cycles with each agent (P = NS). However, complete response for delayed vomiting was observed in only 21 (52.5%) cycles with granisetron and 22 (55%) cycles with ondansetron (P = NS), and delayed nausea was completely controlled in only 11 (27.5%) and ten (25%) cycles respectively (P = NS). In conclusion, both granisetron and ondansetron are effective in controlling acute nausea and vomiting in Chinese patients, with equivalent antiemetic efficacy. Control of delayed nausea and vomiting is less satisfactory. |
Persistent Identifier | http://hdl.handle.net/10722/83484 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 3.000 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Poon, RTP | en_HK |
dc.contributor.author | Chow, LWC | en_HK |
dc.date.accessioned | 2010-09-06T08:41:35Z | - |
dc.date.available | 2010-09-06T08:41:35Z | - |
dc.date.issued | 1998 | en_HK |
dc.identifier.citation | British Journal Of Cancer, 1998, v. 77 n. 10, p. 1683-1685 | en_HK |
dc.identifier.issn | 0007-0920 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/83484 | - |
dc.description.abstract | A double-blind randomized crossover trial was performed to compare the antiemetic efficacy of two 5-HT3 receptor antagonists, granisetron and ondansetron, in Chinese patients receiving adjuvant chemotherapy (cyclophosphamide, methotrexate and 5-fluorouracil) for breast cancer. Twenty patients were randomized to receive chemotherapy with either granisetron on day 1 and ondansetron on day 8 of the first cycle followed by the reverse order in the second cycle, or vice versa. The number of vomiting episodes and the severity of nausea in the first 24 h (acute vomiting/nausea) and the following 7 days (delayed vomiting/nausea) were studied. Acute vomiting was completely prevented in 29 (72.5%) cycles with granisetron and 27 (67.5%) cycles with ondansetron, and treatment failure (> 5 vomiting episodes) occurred in two (5%) cycles with each agent (P = NS). Acute nausea was completely controlled in 15 (37.5%) cycles with granisetron and 14 (35%) cycles with ondansetron, whereas severe acute nausea occurred in four (10%) cycles with each agent (P = NS). However, complete response for delayed vomiting was observed in only 21 (52.5%) cycles with granisetron and 22 (55%) cycles with ondansetron (P = NS), and delayed nausea was completely controlled in only 11 (27.5%) and ten (25%) cycles respectively (P = NS). In conclusion, both granisetron and ondansetron are effective in controlling acute nausea and vomiting in Chinese patients, with equivalent antiemetic efficacy. Control of delayed nausea and vomiting is less satisfactory. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc | en_HK |
dc.relation.ispartof | British Journal of Cancer | en_HK |
dc.subject | Chemotherapy | en_HK |
dc.subject | Chinese | en_HK |
dc.subject | Granisetron | en_HK |
dc.subject | Nausea | en_HK |
dc.subject | Ondansetron | en_HK |
dc.subject | Vomiting | en_HK |
dc.title | Comparison of antiemetic efficacy of granisetron and ondansetron in Oriental patients: A randomized crossover study | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=77&spage=1683&epage=1685&date=1998&atitle=Comparison+of+antiemetic+efficacy+of+granisetron+and+ondansetron+in+oriental+patients:+a+randomized+crossover+study | en_HK |
dc.identifier.email | Poon, RTP: poontp@hkucc.hku.hk | en_HK |
dc.identifier.authority | Poon, RTP=rp00446 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/bjc.1998.277 | - |
dc.identifier.pmid | 9635849 | - |
dc.identifier.scopus | eid_2-s2.0-0031981251 | en_HK |
dc.identifier.hkuros | 31655 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031981251&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 77 | en_HK |
dc.identifier.issue | 10 | en_HK |
dc.identifier.spage | 1683 | en_HK |
dc.identifier.epage | 1685 | en_HK |
dc.identifier.isi | WOS:000073858900024 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Poon, RTP=7103097223 | en_HK |
dc.identifier.scopusauthorid | Chow, LWC=7202532995 | en_HK |
dc.identifier.issnl | 0007-0920 | - |