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- Publisher Website: 10.1002/pmic.200401084
- Scopus: eid_2-s2.0-18844372781
- PMID: 15832367
- WOS: WOS:000229321000023
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Article: Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma
Title | Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma |
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Authors | |
Keywords | Hepatocellular carcinoma Ku autoantigen Monoclonal antibody Tumor marker |
Issue Date | 2005 |
Publisher | Wiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics |
Citation | Proteomics, 2005, v. 5 n. 7, p. 1980-1986 How to Cite? |
Abstract | A murine monoclonal antibody (mAb), CLD3 (IgG1,κ), was generated against hepatocellular carcinoma (HCC). Both immunofluorescence and immunohistochemical assays indicated the reactivity of CLD3 mAb localized at the nucleus and/or cytoplasm of tumorigenic HCC cell lines as well as in liver cancer tissues. By immunoprecipitation and using the matrix-assisted laser desorption/ionization-time of flight mass spectrometry approach, the antigenic specificity of CLD3 was determined to be heterodimeric Ku70 and Ku80 autoantigen, which was confirmed by Western blotting. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA. |
Persistent Identifier | http://hdl.handle.net/10722/83396 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.011 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Luk, JM | en_HK |
dc.contributor.author | Su, YCF | en_HK |
dc.contributor.author | Lam, SCT | en_HK |
dc.contributor.author | Lee, CK | en_HK |
dc.contributor.author | Hu, MY | en_HK |
dc.contributor.author | He, QY | en_HK |
dc.contributor.author | Lau, GK | en_HK |
dc.contributor.author | Wong, FWS | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.date.accessioned | 2010-09-06T08:40:32Z | - |
dc.date.available | 2010-09-06T08:40:32Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Proteomics, 2005, v. 5 n. 7, p. 1980-1986 | en_HK |
dc.identifier.issn | 1615-9853 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/83396 | - |
dc.description.abstract | A murine monoclonal antibody (mAb), CLD3 (IgG1,κ), was generated against hepatocellular carcinoma (HCC). Both immunofluorescence and immunohistochemical assays indicated the reactivity of CLD3 mAb localized at the nucleus and/or cytoplasm of tumorigenic HCC cell lines as well as in liver cancer tissues. By immunoprecipitation and using the matrix-assisted laser desorption/ionization-time of flight mass spectrometry approach, the antigenic specificity of CLD3 was determined to be heterodimeric Ku70 and Ku80 autoantigen, which was confirmed by Western blotting. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Wiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics | en_HK |
dc.relation.ispartof | Proteomics | en_HK |
dc.subject | Hepatocellular carcinoma | en_HK |
dc.subject | Ku autoantigen | en_HK |
dc.subject | Monoclonal antibody | en_HK |
dc.subject | Tumor marker | en_HK |
dc.title | Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-9853&volume=5&issue=7&spage=1980&epage=1986&date=2005&atitle=Proteomic+identification+of+Ku70/Ku80+autoantigen+recognized+by+monoclonal+antibody+against+hepatocellular+carcinoma | en_HK |
dc.identifier.email | Luk, JM: jmluk@hkucc.hku.hk | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.authority | Luk, JM=rp00349 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/pmic.200401084 | en_HK |
dc.identifier.pmid | 15832367 | - |
dc.identifier.scopus | eid_2-s2.0-18844372781 | en_HK |
dc.identifier.hkuros | 98403 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-18844372781&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 5 | en_HK |
dc.identifier.issue | 7 | en_HK |
dc.identifier.spage | 1980 | en_HK |
dc.identifier.epage | 1986 | en_HK |
dc.identifier.isi | WOS:000229321000023 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Luk, JM=7006777791 | en_HK |
dc.identifier.scopusauthorid | Su, YCF=7404456219 | en_HK |
dc.identifier.scopusauthorid | Lam, SCT=8220822600 | en_HK |
dc.identifier.scopusauthorid | Lee, CK=8220822700 | en_HK |
dc.identifier.scopusauthorid | Hu, MY=7402639252 | en_HK |
dc.identifier.scopusauthorid | He, QY=34770287900 | en_HK |
dc.identifier.scopusauthorid | Lau, GK=7102301257 | en_HK |
dc.identifier.scopusauthorid | Wong, FWS=8220823200 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.issnl | 1615-9853 | - |